ID   GLMP_BOVIN              Reviewed;         404 AA.
AC   Q0P5L7;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Glycosylated lysosomal membrane protein {ECO:0000250|UniProtKB:Q8WWB7};
DE   AltName: Full=Lysosomal protein NCU-G1 {ECO:0000250|UniProtKB:Q8WWB7};
DE   Flags: Precursor;
GN   Name=GLMP {ECO:0000250|UniProtKB:Q8WWB7};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required to protect lysosomal transporter MFSD1 from
CC       lysosomal proteolysis and for MFSD1 lysosomal localization.
CC       {ECO:0000250|UniProtKB:Q9JHJ3}.
CC   -!- SUBUNIT: Interacts (via lumenal domain) with lysosomal protein MFSD1;
CC       the interaction starts while both proteins are still in the endoplasmic
CC       reticulum and is required for stability and lysosomal localization of
CC       MFSD1. {ECO:0000250|UniProtKB:Q9JHJ3}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q9JHJ3};
CC       Single-pass type I membrane protein {ECO:0000255}; Lumenal side
CC       {ECO:0000305}.
CC   -!- PTM: Highly N-glycosylated. N-glycosylation is essential for GLMP
CC       stability and for MFSD1 lysosomal localization.
CC       {ECO:0000250|UniProtKB:Q9JHJ3}.
CC   -!- SIMILARITY: Belongs to the GLMP family. {ECO:0000305}.
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DR   EMBL; BC119876; AAI19877.1; -; mRNA.
DR   RefSeq; NP_001098946.1; NM_001105476.1.
DR   AlphaFoldDB; Q0P5L7; -.
DR   SMR; Q0P5L7; -.
DR   STRING; 9913.ENSBTAP00000008351; -.
DR   PaxDb; Q0P5L7; -.
DR   PRIDE; Q0P5L7; -.
DR   Ensembl; ENSBTAT00000008351; ENSBTAP00000008351; ENSBTAG00000006364.
DR   GeneID; 100125876; -.
DR   KEGG; bta:100125876; -.
DR   CTD; 112770; -.
DR   VEuPathDB; HostDB:ENSBTAG00000006364; -.
DR   VGNC; VGNC:29409; GLMP.
DR   eggNOG; ENOG502QSBM; Eukaryota.
DR   GeneTree; ENSGT00390000005131; -.
DR   HOGENOM; CLU_040225_0_0_1; -.
DR   InParanoid; Q0P5L7; -.
DR   OMA; TLHYLWD; -.
DR   OrthoDB; 562253at2759; -.
DR   TreeFam; TF324431; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000006364; Expressed in digestive system secreted substance and 105 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; ISS:UniProtKB.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0061462; P:protein localization to lysosome; ISS:UniProtKB.
DR   GO; GO:0050821; P:protein stabilization; ISS:UniProtKB.
DR   InterPro; IPR029382; NCU-G1.
DR   PANTHER; PTHR31981; PTHR31981; 1.
DR   Pfam; PF15065; NCU-G1; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Lysosome; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..404
FT                   /note="Glycosylated lysosomal membrane protein"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000284483"
FT   TOPO_DOM        27..370
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        371..391
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        392..404
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   MOTIF           400..404
FT                   /note="Lysosomal targeting motif"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JHJ3"
FT   CARBOHYD        63
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        132
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        157
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        185
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        228
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   404 AA;  43531 MW;  298779EA45A56C53 CRC64;
     MSGYEKPSRG WGFCALSPVL LSLLMAAPLG LLGEETRQVS LKVISNRLDF SQNLLHIRAV
     GTNSTLHYVW SSLGPPAVLL VATNTPNSTL SVNWSLLLSS DPDGGLMVLP EESIQFSSAL
     VFTRLFEFDS TNMSDAASRP LGKSYPPYSL ANFSWNNITD SLDPATLSAT FRGHPIRDPT
     GAFTNGSLAF RVQAFSTSGR PAQPPRLLHS ADTCQLEVAL VGASPRGNRS LFGLEVATLG
     QGPGCPSMQE QHSIDDEYTP AVFQLDQLLW GSLPSGFMQW RPVAFSQKRG SRDSAMPCQS
     SPLHPTLAYL LPQSPIVRAF FKTQDHSCAF NLTFGASTGP GYWDQHYLSW SVLLGVGTPP
     VDALSPLVLG IMAVALGAPA LMLLAGGLFL LLGRKRDSEY QSIN