GLMP_DANRE
ID GLMP_DANRE Reviewed; 407 AA.
AC Q66HW4;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Glycosylated lysosomal membrane protein {ECO:0000250|UniProtKB:Q8WWB7};
DE AltName: Full=Lysosomal protein NCU-G1 {ECO:0000250|UniProtKB:Q8WWB7};
DE Flags: Precursor;
GN Name=glmp; ORFNames=si:dkey-263h23.3, zgc:92308;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required to protect lysosomal transporter MFSD1 from
CC lysosomal proteolysis and for MFSD1 lysosomal localization.
CC {ECO:0000250|UniProtKB:Q9JHJ3}.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q9JHJ3};
CC Single-pass type I membrane protein {ECO:0000255}; Lumenal side
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the GLMP family. {ECO:0000305}.
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DR EMBL; CR391989; CAK10879.1; -; Genomic_DNA.
DR EMBL; BC081645; AAH81645.1; -; mRNA.
DR RefSeq; NP_001004580.1; NM_001004580.1.
DR AlphaFoldDB; Q66HW4; -.
DR SMR; Q66HW4; -.
DR STRING; 7955.ENSDARP00000076889; -.
DR PaxDb; Q66HW4; -.
DR Ensembl; ENSDART00000082454; ENSDARP00000076889; ENSDARG00000059354.
DR GeneID; 447841; -.
DR KEGG; dre:447841; -.
DR CTD; 112770; -.
DR ZFIN; ZDB-GENE-040912-142; glmp.
DR eggNOG; ENOG502QSBM; Eukaryota.
DR GeneTree; ENSGT00390000005131; -.
DR HOGENOM; CLU_040225_0_0_1; -.
DR InParanoid; Q66HW4; -.
DR OMA; TLHYLWD; -.
DR OrthoDB; 562253at2759; -.
DR PhylomeDB; Q66HW4; -.
DR TreeFam; TF324431; -.
DR PRO; PR:Q66HW4; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 19.
DR Bgee; ENSDARG00000059354; Expressed in intestine and 27 other tissues.
DR GO; GO:0016021; C:integral component of membrane; ISS:UniProtKB.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR GO; GO:0061462; P:protein localization to lysosome; ISS:UniProtKB.
DR GO; GO:0050821; P:protein stabilization; ISS:UniProtKB.
DR InterPro; IPR029382; NCU-G1.
DR PANTHER; PTHR31981; PTHR31981; 1.
DR Pfam; PF15065; NCU-G1; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Lysosome; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..407
FT /note="Glycosylated lysosomal membrane protein"
FT /evidence="ECO:0000305"
FT /id="PRO_0000284488"
FT TOPO_DOM 23..368
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 390..407
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOTIF 403..407
FT /note="Lysosomal targeting motif"
FT /evidence="ECO:0000250|UniProtKB:Q9JHJ3"
FT CARBOHYD 63
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 84
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 99
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 132
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 160
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 164
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 183
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 210
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 226
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 272
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 331
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 407 AA; 44641 MW; A66D95AFA1B38BC3 CRC64;
MSMFKVSLIC SLLLVVFGAA RGFLGRGDAF RRKVSVELNP GLAPPLSLPP GVGLVHLRGL
GDNDTLHFVL CNAGAPALLL VHSNSTRSAV TVDWPEFINS SSAGSLRVEP ESSVTYSSAL
VFTRLWEYDD VNNTADPQKA AESSFYPPYE LQNFVWSELN TTLNQSEHTV VLCGGEKTQS
FSNGSLCLQV SVFESQGRDE AWPSLLHNAN SSQLRVWING VTPRGNNSRF ILEFQSVGDA
GFQSRVDMRS SIDDEYTPSI FKVSEWVSSP VNSSSVWGFS QWKPVAYRKA RPVFEDATAC
RHSELVFVNG TPPSAVIQAY FTHNTRIYGL NISFGLAEDP VFYDATKYIS WTVLMGLGDP
PSDSFSPLII IIITVGLVTP LVFIILGGVF VCVRKRTSQS TAYEPIN
