ID   GLMP_PONAB              Reviewed;         404 AA.
AC   Q5RBU0;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=Glycosylated lysosomal membrane protein {ECO:0000250|UniProtKB:Q8WWB7};
DE   AltName: Full=Lysosomal protein NCU-G1 {ECO:0000250|UniProtKB:Q8WWB7};
DE   Flags: Precursor;
GN   Name=GLMP {ECO:0000250|UniProtKB:Q8WWB7};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required to protect lysosomal transporter MFSD1 from
CC       lysosomal proteolysis and for MFSD1 lysosomal localization.
CC       {ECO:0000250|UniProtKB:Q9JHJ3}.
CC   -!- SUBUNIT: Interacts (via lumenal domain) with lysosomal protein MFSD1;
CC       the interaction starts while both proteins are still in the endoplasmic
CC       reticulum and is required for stability and lysosomal localization of
CC       MFSD1. {ECO:0000250|UniProtKB:Q9JHJ3}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q9JHJ3};
CC       Single-pass type I membrane protein {ECO:0000255}; Lumenal side
CC       {ECO:0000305}.
CC   -!- PTM: Highly N-glycosylated. N-glycosylation is essential for GLMP
CC       stability and for MFSD1 lysosomal localization.
CC       {ECO:0000250|UniProtKB:Q9JHJ3}.
CC   -!- SIMILARITY: Belongs to the GLMP family. {ECO:0000305}.
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DR   EMBL; CR858543; CAH90770.1; -; Transcribed_RNA.
DR   AlphaFoldDB; Q5RBU0; -.
DR   SMR; Q5RBU0; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; ISS:UniProtKB.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR   GO; GO:0061462; P:protein localization to lysosome; ISS:UniProtKB.
DR   GO; GO:0050821; P:protein stabilization; ISS:UniProtKB.
DR   InterPro; IPR029382; NCU-G1.
DR   PANTHER; PTHR31981; PTHR31981; 1.
DR   Pfam; PF15065; NCU-G1; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Lysosome; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..35
FT                   /evidence="ECO:0000255"
FT   CHAIN           36..404
FT                   /note="Glycosylated lysosomal membrane protein"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000284486"
FT   TOPO_DOM        36..371
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        372..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        393..404
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   MOTIF           400..404
FT                   /note="Lysosomal targeting motif"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JHJ3"
FT   CARBOHYD        65
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        134
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        159
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        186
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        229
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   404 AA;  43569 MW;  FA698617DA9F652C CRC64;
     MRGSVERGWG WGHCASSPLL LWTLLLFAAP FGLLGEKTRQ LSLEVIPNWL GPLQNLLHIR
     AVGTNSTLHY VWSSLGPLAV VMVATNTPHS TLSVNWSRLL SPEPDGGLMV LPKDSIQFSS
     ALVFTRLLEF DSTNVSNTAA KPPGRPYPPY SLADFSWNNI TDSLPATLSA TFQGHPMNDP
     TRTFANGSLA FRVQAFSRSS RPAQPPRLLH TADTCQLEVA LVGASPRGNH SLFGLEVATL
     GQGPDCPSMQ EQHSIDDEYA PAVFQLDQLL WGSLPAGFAQ WRPVAYSQKP GGRESALPCQ
     ASPLHPALAY SLPQSPIVRA FFGSQNNFCA FNLTFGASTG PGYWDQHYLS WNAPGCGLPS
     SGRLVPTSPG HHGSALGAPG LMLLGGGLVL LLHHRKYSEY QSIN