ID   GLMP_RAT                Reviewed;         404 AA.
AC   Q68FV6;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Glycosylated lysosomal membrane protein {ECO:0000312|RGD:1303130};
DE   AltName: Full=Lysosomal protein NCU-G1 {ECO:0000312|RGD:1303130};
DE   Flags: Precursor;
GN   Name=Glmp {ECO:0000312|RGD:1303130};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Required to protect lysosomal transporter MFSD1 from
CC       lysosomal proteolysis and for MFSD1 lysosomal localization.
CC       {ECO:0000250|UniProtKB:Q9JHJ3}.
CC   -!- SUBUNIT: Interacts (via lumenal domain) with lysosomal protein MFSD1;
CC       the interaction starts while both proteins are still in the endoplasmic
CC       reticulum and is required for stability and lysosomal localization of
CC       MFSD1. {ECO:0000250|UniProtKB:Q9JHJ3}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q9JHJ3};
CC       Single-pass type I membrane protein {ECO:0000255}; Lumenal side
CC       {ECO:0000305}.
CC   -!- PTM: Highly N-glycosylated. N-glycosylation is essential for GLMP
CC       stability and for MFSD1 lysosomal localization.
CC       {ECO:0000250|UniProtKB:Q9JHJ3}.
CC   -!- SIMILARITY: Belongs to the GLMP family. {ECO:0000305}.
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DR   EMBL; BC079294; AAH79294.1; -; mRNA.
DR   RefSeq; NP_001004226.1; NM_001004226.1.
DR   AlphaFoldDB; Q68FV6; -.
DR   SMR; Q68FV6; -.
DR   IntAct; Q68FV6; 1.
DR   STRING; 10116.ENSRNOP00000026152; -.
DR   GlyGen; Q68FV6; 5 sites.
DR   PaxDb; Q68FV6; -.
DR   Ensembl; ENSRNOT00000026153; ENSRNOP00000026152; ENSRNOG00000019281.
DR   GeneID; 295231; -.
DR   KEGG; rno:295231; -.
DR   UCSC; RGD:1303130; rat.
DR   CTD; 112770; -.
DR   RGD; 1303130; Glmp.
DR   eggNOG; ENOG502QSBM; Eukaryota.
DR   GeneTree; ENSGT00390000005131; -.
DR   HOGENOM; CLU_040225_0_0_1; -.
DR   InParanoid; Q68FV6; -.
DR   OMA; TLHYLWD; -.
DR   OrthoDB; 562253at2759; -.
DR   PhylomeDB; Q68FV6; -.
DR   TreeFam; TF324431; -.
DR   PRO; PR:Q68FV6; -.
DR   Proteomes; UP000002494; Chromosome 2.
DR   Bgee; ENSRNOG00000019281; Expressed in ovary and 19 other tissues.
DR   Genevisible; Q68FV6; RN.
DR   GO; GO:0005829; C:cytosol; ISO:RGD.
DR   GO; GO:0016021; C:integral component of membrane; ISS:UniProtKB.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0061462; P:protein localization to lysosome; ISS:UniProtKB.
DR   GO; GO:0050821; P:protein stabilization; ISS:UniProtKB.
DR   InterPro; IPR029382; NCU-G1.
DR   PANTHER; PTHR31981; PTHR31981; 1.
DR   Pfam; PF15065; NCU-G1; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Lysosome; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..35
FT                   /evidence="ECO:0000255"
FT   CHAIN           36..404
FT                   /note="Glycosylated lysosomal membrane protein"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000284487"
FT   TOPO_DOM        36..370
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        371..391
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        392..404
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   MOTIF           400..404
FT                   /note="Lysosomal targeting motif"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JHJ3"
FT   CARBOHYD        64
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        133
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        157
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        185
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        228
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   404 AA;  43871 MW;  804B1986B544557D CRC64;
     MLRCWGPHWG WVPWAPTPWL LLSLLVCTVP FGLLGEETRQ VSMEVISGWP NPQNLLHIRA
     VGSNSTLHYV WSSLGPPAVV LVATNTTQSV LNVNWSLLLS PDPAGALMVL PKNSIQFSSA
     LVFTRLLEFD STNVSEGTQP PGKPYPPYSL AKFSWNNVTN SLDLATLSAI FRGHPVDDPT
     GAFANGSLTF KVQAFSRSGR PAQPPRLLHT ADVCQVEVAL VGASPRGNHS LFGLEVATLG
     QGPDCPSVNE QDSIDDEYAP AVFQLNRLLW GSSPSGFMQW RPVAFSQEQR ARESALACQA
     SALHPTLAYP LPHSPIVQAF FGSQNNFCAF NLTFGAPTGP GYWDQHYLCW SMLLGIGFPP
     VDSFSPLVLG IMAVALGAPG LMFLGGGLFL LLRHKQYSEY QSIN