ID   GLMP_SALSA              Reviewed;         406 AA.
AC   C0HBB2;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 28.
DE   RecName: Full=Glycosylated lysosomal membrane protein {ECO:0000250|UniProtKB:Q8WWB7};
DE   AltName: Full=Lysosomal protein NCU-G1 {ECO:0000250|UniProtKB:Q8WWB7};
DE   Flags: Precursor;
GN   Name=glmp;
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA   Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA   Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA   Koop B.F.;
RT   "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT   evolutionary pressures on a post-tetraploidization genome.";
RL   BMC Genomics 11:279-279(2010).
CC   -!- FUNCTION: Required to protect lysosomal transporter MFSD1 from
CC       lysosomal proteolysis and for MFSD1 lysosomal localization.
CC       {ECO:0000250|UniProtKB:Q9JHJ3}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q9JHJ3};
CC       Single-pass type I membrane protein {ECO:0000255}; Lumenal side
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the GLMP family. {ECO:0000305}.
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DR   EMBL; BT059618; ACN11331.1; -; mRNA.
DR   RefSeq; NP_001167308.1; NM_001173837.1.
DR   AlphaFoldDB; C0HBB2; -.
DR   SMR; C0HBB2; -.
DR   STRING; 8030.ENSSSAP00000034497; -.
DR   GeneID; 100380552; -.
DR   KEGG; sasa:100380552; -.
DR   CTD; 112770; -.
DR   OrthoDB; 562253at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa14.
DR   GO; GO:0016021; C:integral component of membrane; ISS:UniProtKB.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR   GO; GO:0061462; P:protein localization to lysosome; ISS:UniProtKB.
DR   GO; GO:0050821; P:protein stabilization; ISS:UniProtKB.
DR   InterPro; IPR029382; NCU-G1.
DR   PANTHER; PTHR31981; PTHR31981; 1.
DR   Pfam; PF15065; NCU-G1; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Lysosome; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..406
FT                   /note="Glycosylated lysosomal membrane protein"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000381837"
FT   TOPO_DOM        21..367
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        368..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        389..406
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   MOTIF           402..406
FT                   /note="Lysosomal targeting motif"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JHJ3"
FT   CARBOHYD        31
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        41
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        62
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        83
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        100
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        131
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        152
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        159
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        182
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        209
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        225
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        271
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        331
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        343
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   406 AA;  44678 MW;  97DA24252DDF7911 CRC64;
     MYTIHFYVLF VLLTVRCSSS FIGNGENYRR NLSLELNPGL NSSLMPLPPG VGLLHVRALG
     KNNTLHYLLC SQGAPALLLV HTNSTSSKVK VDWPAFLVQN TTGSLKLTPE SSVLYSNTLV
     FTRLWEYDDV NDTAVPEHLP PSSFFQPYEL QNFTWDDLNK TLDPMAYTAL LCGRDASESF
     SNGSLCLKFS AFDVEGRDQG WPSLLHNANS SQLRVVLDGV VPRSNRSRFS LELQVVGGTQ
     SMSRVDVLRS IDDEYTPSIF KVSQWVSSPV NSTSPVLGYA QWKPVAYRRP SPVFEDATPC
     RHSTPVPIAQ LPPSGLVLAY YGGESQTTGL NMTFSITGDP FYNTTNYLSW TVLVGLGSPP
     VDSFSPLVLV IMAVGLGTPM LIILLGGVCV CVRKNRPQPQ VYEPIN