ALSR_BACSU
ID ALSR_BACSU Reviewed; 302 AA.
AC Q04778;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=HTH-type transcriptional regulator AlsR;
DE AltName: Full=Als operon regulatory protein;
GN Name=alsR; OrderedLocusNames=BSU36020;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7685336; DOI=10.1128/jb.175.12.3863-3875.1993;
RA Renna M.C., Najimudin N., Winik L.R., Zahler S.A.;
RT "Regulation of the Bacillus subtilis alsS, alsD, and alsR genes involved in
RT post-exponential-phase production of acetoin.";
RL J. Bacteriol. 175:3863-3875(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9353933; DOI=10.1099/00221287-143-10-3313;
RA Presecan E., Moszer I., Boursier L., Cruz Ramos H., De La Fuente V.,
RA Hullo M.-F., Lelong C., Schleich S., Sekowska A., Song B.H., Villani G.,
RA Kunst F., Danchin A., Glaser P.;
RT "The Bacillus subtilis genome from gerBC (311 degrees) to licR (334
RT degrees).";
RL Microbiology 143:3313-3328(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
CC -!- FUNCTION: Regulates the expression of the alsSD operon for acetoin
CC biosynthesis.
CC -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC {ECO:0000305}.
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DR EMBL; L04470; AAA22221.1; -; Genomic_DNA.
DR EMBL; Z93767; CAB07788.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB15619.1; -; Genomic_DNA.
DR PIR; A47126; A47126.
DR RefSeq; NP_391483.1; NC_000964.3.
DR RefSeq; WP_003227859.1; NZ_JNCM01000034.1.
DR AlphaFoldDB; Q04778; -.
DR SMR; Q04778; -.
DR IntAct; Q04778; 1.
DR STRING; 224308.BSU36020; -.
DR PaxDb; Q04778; -.
DR PRIDE; Q04778; -.
DR EnsemblBacteria; CAB15619; CAB15619; BSU_36020.
DR GeneID; 936860; -.
DR KEGG; bsu:BSU36020; -.
DR PATRIC; fig|224308.179.peg.3899; -.
DR eggNOG; COG0583; Bacteria.
DR InParanoid; Q04778; -.
DR OMA; GKQPELC; -.
DR PhylomeDB; Q04778; -.
DR BioCyc; BSUB:BSU36020-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0032993; C:protein-DNA complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0045151; P:acetoin biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd08452; PBP2_AlsR; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR037411; AlsR_PBP2.
DR InterPro; IPR005119; LysR_subst-bd.
DR InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00126; HTH_1; 1.
DR Pfam; PF03466; LysR_substrate; 1.
DR PRINTS; PR00039; HTHLYSR.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50931; HTH_LYSR; 1.
PE 3: Inferred from homology;
KW Acetoin biosynthesis; DNA-binding; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..302
FT /note="HTH-type transcriptional regulator AlsR"
FT /id="PRO_0000105584"
FT DOMAIN 1..58
FT /note="HTH lysR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT DNA_BIND 18..37
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ SEQUENCE 302 AA; 34333 MW; BCA4DF5CF95A3E33 CRC64;
MELRHLQYFI AVAEELHFGK AARRLNMTQP PLSQQIKQLE EEVGVTLLKR TKRFVELTAA
GEIFLNHCRM ALMQIGQGIE LAQRTARGEQ GLLVIGFVGS ATYEFLPPIV REYRKKFPSV
KIELREISSS RQQEELLKGN IDIGILHPPL QHTALHIETA QSSPCVLALP KQHPLTSKES
ITIEDLRDEP IITVAKEAWP TLYMDFIQFC EQAGFRPNIV QEATEYQMVI GLVSAGIGMT
FVPSSAKKLF NLDVTYRKMD QIQLNAEWVI AYRKDNHNPL IKHFIHISNC QQTRTKESDA
GT
