ID   ALS_PAPHA               Reviewed;         605 AA.
AC   O02833;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Insulin-like growth factor-binding protein complex acid labile subunit;
DE            Short=ALS;
DE   Flags: Precursor;
GN   Name=IGFALS; Synonyms=ALS;
OS   Papio hamadryas (Hamadryas baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9557;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=8886027; DOI=10.1006/bbrc.1996.1602;
RA   Delhanty P., Baxter R.C.;
RT   "The cloning and expression of the baboon acid-labile subunit of the
RT   insulin-like growth factor binding protein complex.";
RL   Biochem. Biophys. Res. Commun. 227:897-902(1996).
CC   -!- FUNCTION: Involved in protein-protein interactions that result in
CC       protein complexes, receptor-ligand binding or cell adhesion.
CC   -!- SUBUNIT: Forms a ternary complex of about 140 to 150 kDa with IGF-I or
CC       IGF-II and IGFBP-3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space.
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DR   EMBL; S83462; AAN86722.1; -; mRNA.
DR   AlphaFoldDB; O02833; -.
DR   SMR; O02833; -.
DR   PRIDE; O02833; -.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; -; 3.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000372; LRRNT.
DR   Pfam; PF13855; LRR_8; 6.
DR   Pfam; PF01462; LRRNT; 1.
DR   SMART; SM00369; LRR_TYP; 19.
DR   SMART; SM00082; LRRCT; 1.
DR   SMART; SM00013; LRRNT; 1.
DR   PROSITE; PS51450; LRR; 18.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Glycoprotein; Leucine-rich repeat; Repeat; Secreted; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000250"
FT   CHAIN           28..605
FT                   /note="Insulin-like growth factor-binding protein complex
FT                   acid labile subunit"
FT                   /id="PRO_0000020697"
FT   DOMAIN          32..74
FT                   /note="LRRNT"
FT   REPEAT          75..96
FT                   /note="LRR 1"
FT   REPEAT          99..120
FT                   /note="LRR 2"
FT   REPEAT          123..144
FT                   /note="LRR 3"
FT   REPEAT          147..168
FT                   /note="LRR 4"
FT   REPEAT          171..192
FT                   /note="LRR 5"
FT   REPEAT          195..216
FT                   /note="LRR 6"
FT   REPEAT          219..240
FT                   /note="LRR 7"
FT   REPEAT          243..264
FT                   /note="LRR 8"
FT   REPEAT          267..288
FT                   /note="LRR 9"
FT   REPEAT          291..312
FT                   /note="LRR 10"
FT   REPEAT          315..336
FT                   /note="LRR 11"
FT   REPEAT          339..360
FT                   /note="LRR 12"
FT   REPEAT          363..384
FT                   /note="LRR 13"
FT   REPEAT          387..408
FT                   /note="LRR 14"
FT   REPEAT          411..432
FT                   /note="LRR 15"
FT   REPEAT          435..456
FT                   /note="LRR 16"
FT   REPEAT          459..480
FT                   /note="LRR 17"
FT   REPEAT          483..504
FT                   /note="LRR 18"
FT   REPEAT          507..528
FT                   /note="LRR 19"
FT   DOMAIN          536..605
FT                   /note="LRRCT"
FT   CARBOHYD        64
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        85
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        96
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        368
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        515
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        580
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   605 AA;  66111 MW;  9D71994625F23652 CRC64;
     MALRKGGLAL ALLLLSWVAL GPRSLEGAEP GTPGEAEGPA CPATCACSYD DEVNELSVFC
     SSRNLTRLPD GIPGGTQALW LDSNNLSSIP PAAFRNLSSL AFLNLQGGQL GSLEPQALLG
     LENLCHLHLE RNQLRSLAVG TFAYTPALAL LGLSNNRLSR LEDGLFEGLG NLWDLNLGWN
     SLAVLPDAAF RGLGGLRELV LAGNRLAYLQ PALFSGLAEL RELDLSRNAL RAIKANVFAQ
     LPRLQKLYLD RNLIAAVAPG AFLGLKALRW LDLSHNRVAG LLEDTFPGLL GLRVLRLSHN
     AIASLRPRTF EDLHFLEELQ LGHNRIRQLA ERSFEGLGQL EVLTLDHNQL QEVKVGAFLG
     LTNVAVMNLS GNCLRNLPEQ VFRGLGKLHS LHLEGSCLGR IRPHTFAGLS GLRRLFLKDN
     GLVGIEEQSL WGLAELLELD LTSNQLTHLP HQLFQGLGKL EYLLLSHNRL AELPADALGP
     LQRAFWLDVS HNRLEALPGS LLASLGRLRY LNLRNNSLRT FTPQPPGLER LWLEGNPWDC
     SCPLKALRDF ALQNPSAVPR FVQAICEGDD CQPPVYTYNN ITCASPPEVA GLDLRDLGEA
     HFAPC