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ALS_RAT
ID   ALS_RAT                 Reviewed;         603 AA.
AC   P35859;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 134.
DE   RecName: Full=Insulin-like growth factor-binding protein complex acid labile subunit;
DE            Short=ALS;
DE   Flags: Precursor;
GN   Name=Igfals; Synonyms=Als;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=1384485; DOI=10.1016/0006-291x(92)92385-b;
RA   Dai J., Baxter R.C.;
RT   "Molecular cloning of the acid-labile subunit of the rat insulin-like
RT   growth factor binding protein complex.";
RL   Biochem. Biophys. Res. Commun. 188:304-309(1992).
RN   [2]
RP   PROTEIN SEQUENCE OF 24-44, AND CHARACTERIZATION.
RC   STRAIN=Wistar; TISSUE=Serum;
RX   PubMed=7507839; DOI=10.1210/endo.134.2.7507839;
RA   Baxter R.C., Dai J.;
RT   "Purification and characterization of the acid-labile subunit of rat serum
RT   insulin-like growth factor binding protein complex.";
RL   Endocrinology 134:848-852(1994).
CC   -!- FUNCTION: May have an important role in regulating the access of
CC       circulating IGFs to the tissues.
CC   -!- SUBUNIT: Forms a ternary complex of about 140 to 150 kDa with IGF-I or
CC       IGF-II and IGFBP-3.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space.
CC   -!- TISSUE SPECIFICITY: Brain, kidney, lung, heart, spleen, muscle and
CC       liver.
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DR   EMBL; S46785; AAB23770.2; -; mRNA.
DR   PIR; JC1282; JC1282.
DR   RefSeq; NP_445781.2; NM_053329.2.
DR   AlphaFoldDB; P35859; -.
DR   SMR; P35859; -.
DR   STRING; 10116.ENSRNOP00000020233; -.
DR   GlyGen; P35859; 7 sites.
DR   PaxDb; P35859; -.
DR   GeneID; 79438; -.
DR   KEGG; rno:79438; -.
DR   UCSC; RGD:68429; rat.
DR   CTD; 3483; -.
DR   RGD; 68429; Igfals.
DR   eggNOG; KOG0619; Eukaryota.
DR   InParanoid; P35859; -.
DR   OrthoDB; 826997at2759; -.
DR   PhylomeDB; P35859; -.
DR   Reactome; R-RNO-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
DR   PRO; PR:P35859; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0042567; C:insulin-like growth factor ternary complex; IDA:RGD.
DR   GO; GO:0005520; F:insulin-like growth factor binding; IDA:RGD.
DR   GO; GO:0007568; P:aging; IEP:RGD.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0071549; P:cellular response to dexamethasone stimulus; IEP:RGD.
DR   GO; GO:0071364; P:cellular response to epidermal growth factor stimulus; IEP:RGD.
DR   GO; GO:0071378; P:cellular response to growth hormone stimulus; IEP:RGD.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IEP:RGD.
DR   GO; GO:0031667; P:response to nutrient levels; IEP:RGD.
DR   Gene3D; 3.80.10.10; -; 4.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000372; LRRNT.
DR   Pfam; PF13855; LRR_8; 4.
DR   Pfam; PF01462; LRRNT; 1.
DR   SMART; SM00369; LRR_TYP; 19.
DR   SMART; SM00082; LRRCT; 1.
DR   SMART; SM00013; LRRNT; 1.
PE   1: Evidence at protein level;
KW   Cell adhesion; Direct protein sequencing; Glycoprotein;
KW   Leucine-rich repeat; Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000269|PubMed:7507839"
FT   CHAIN           24..603
FT                   /note="Insulin-like growth factor-binding protein complex
FT                   acid labile subunit"
FT                   /id="PRO_0000020698"
FT   DOMAIN          32..74
FT                   /note="LRRNT"
FT   REPEAT          75..96
FT                   /note="LRR 1"
FT   REPEAT          99..120
FT                   /note="LRR 2"
FT   REPEAT          123..144
FT                   /note="LRR 3"
FT   REPEAT          147..168
FT                   /note="LRR 4"
FT   REPEAT          171..192
FT                   /note="LRR 5"
FT   REPEAT          195..216
FT                   /note="LRR 6"
FT   REPEAT          219..240
FT                   /note="LRR 7"
FT   REPEAT          243..264
FT                   /note="LRR 8"
FT   REPEAT          267..288
FT                   /note="LRR 9"
FT   REPEAT          291..312
FT                   /note="LRR 10"
FT   REPEAT          315..336
FT                   /note="LRR 11"
FT   REPEAT          339..360
FT                   /note="LRR 12"
FT   REPEAT          363..384
FT                   /note="LRR 13"
FT   REPEAT          387..408
FT                   /note="LRR 14"
FT   REPEAT          411..432
FT                   /note="LRR 15"
FT   REPEAT          435..456
FT                   /note="LRR 16"
FT   REPEAT          459..480
FT                   /note="LRR 17"
FT   REPEAT          483..504
FT                   /note="LRR 18"
FT   REPEAT          507..528
FT                   /note="LRR 19"
FT   DOMAIN          535..603
FT                   /note="LRRCT"
FT   CARBOHYD        64
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        85
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        96
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        368
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        515
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        578
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        586
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   603 AA;  66812 MW;  DCD7637D94A5037C CRC64;
     MALRTGGPAL VVLLAFWVAL GPCHLQGTDP GASADAEGPQ CPVACTCSHD DYTDELSVFC
     SSKNLTHLPD DIPVSTRALW LDGNNLSSIP SAAFQNLSSL DFLNLQGSWL RSLEPQALLG
     LQNLYYLHLE RNRLRNLAVG LFTHTPSLAS LSLSSNLLGR LEEGLFQGLS HLWDLNLGWN
     SLVVLPDTVF QGLGNLHELV LAGNKLTYLQ PALFCGLGEL RELDLSRNAL RSVKANVFVH
     LPRLQKLYLD RNLITAVAPG AFLGMKALRW LDLSHNRVAG LMEDTFPGLL GLHVLRLAHN
     AIASLRPRTF KDLHFLEELQ LGHNRIRQLG ERTFEGLGQL EVLTLNDNQI TEVRVGAFSG
     LFNVAVMNLS GNCLRSLPER VFQGLDKLHS LHLEHSCLGH VRLHTFAGLS GLRRLFLRDN
     SISSIEEQSL AGLSELLELD LTTNRLTHLP RQLFQGLGHL EYLLLSYNQL TTLSAEVLGP
     LQRAFWLDIS HNHLETLAEG LFSSLGRVRY LSLRNNSLQT FSPQPGLERL WLDANPWDCS
     CPLKALRDFA LQNPGVVPRF VQTVCEGDDC QPVYTYNNIT CAGPANVSGL DLRDVSETHF
     VHC
 
 
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