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ALT13_ALTAL
ID   ALT13_ALTAL             Reviewed;         634 AA.
AC   A0A3G9HCC8;
DT   17-JUN-2020, integrated into UniProtKB/Swiss-Prot.
DT   13-FEB-2019, sequence version 1.
DT   25-MAY-2022, entry version 14.
DE   RecName: Full=AAl-toxin cluster-specific transcription factor ALT13 {ECO:0000305};
DE   AltName: Full=AAL-toxin biosynthesis cluster protein 13 {ECO:0000303|Ref.1};
GN   Name=ALT13 {ECO:0000303|Ref.1};
OS   Alternaria alternata (Alternaria rot fungus) (Torula alternata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Alternaria;
OC   Alternaria sect. Alternaria; Alternaria alternata complex.
OX   NCBI_TaxID=5599;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=As-27;
RA   Akagi Y., Akamatsu H., Takao K., Tsuge T., Kodama M.;
RT   "AAL-toxin biosynthetic genes cluster in the tomato pathotype of Alternaria
RT   alternata.";
RL   Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION.
RX   PubMed=19749175; DOI=10.1128/ec.00135-09;
RA   Akagi Y., Akamatsu H., Otani H., Kodama M.;
RT   "Horizontal chromosome transfer, a mechanism for the evolution and
RT   differentiation of a plant-pathogenic fungus.";
RL   Eukaryot. Cell 8:1732-1738(2009).
CC   -!- FUNCTION: Transcription factor that regulates the expression of the
CC       gene cluster that mediates the biosynthesis of AAL-toxins, sphinganine-
CC       analog mycotoxins responsible for Alternaria stem canker on tomato by
CC       the tomato pathotype. {ECO:0000305|PubMed:19749175}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- MISCELLANEOUS: Gene clusters encoding host-selective toxins (HSTs) are
CC       localized on conditionally dispensable chromosomes (CDCs), also called
CC       supernumerary chromosomes, where they are present in multiple copies.
CC       The CDCs are not essential for saprophytic growth but controls host-
CC       selective pathogenicity. {ECO:0000269|PubMed:19749175}.
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DR   EMBL; AB969680; BBG74281.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3G9HCC8; -.
DR   SMR; A0A3G9HCC8; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..634
FT                   /note="AAl-toxin cluster-specific transcription factor
FT                   ALT13"
FT                   /id="PRO_0000449865"
FT   DNA_BIND        30..56
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          66..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   634 AA;  70663 MW;  D2F2A4C30CEB3418 CRC64;
     MSTEFVFVDH QAAQASVRQK PKLSRRRGAC ENCKRRKVRC SGANPCEQCL KVNVHCWYIG
     NNQSRRRSVP NSGADKNNQQ GDTDRHNGAR LGLESFGHLH FFSESFLDAQ SIPMDQPPGS
     SPVMDFDPYD YDASPLSMSN EQTALIDWDQ LEATSNYVAL GISANSGNNF IADQCFSETR
     TATNRASKDP LNGGCHNTLH TGEFTHDSRT VDELLNDSIP LAFAASTKSS LSFDYVRSSL
     HSWLLTAMTE LDGDENRHIL QTFERLLNAN SPVIRHPSLN EDVNSIEILN SLRSESSQNR
     ALVYRCIDAC FSNPNRVGIF LDRMTVEELV CQVLAHPFVS SPISIALCLS FLAVGSRDLS
     LDDDCREMNA MNLFRTALYI RPNPSSGPSL WTFQALLLMA HFSCDIGAES TTSLMTDTAT
     CVQALRLHSS AAISNLCSSD SERVNLKRAF WTFFAVEKLH CIQEGLFPLI HGEYADHKVA
     APQDPLCRRY DCLYSDVGYA KICSKILQQL QGQQDISQVG SSCCGRESYK QSPAFTANRL
     ETMLMEWKGN LPFDGDGKNI FTATSPGERR IRLTCINMYH FAMIAIHSLP GVEDTDASKR
     QRCESAREIL DMSEHITSAD LLYDWSVPPL CPDC
 
 
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