ID   ALT2B_ENMGO             Reviewed;         129 AA.
AC   P0DJX8;
DT   24-JUL-2013, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2013, sequence version 1.
DT   23-FEB-2022, entry version 14.
DE   RecName: Full=Protein 2B*;
OS   Mengo encephalomyocarditis virus.
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Picornavirales; Picornaviridae; Cardiovirus.
OX   NCBI_TaxID=12107;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9544; Macaca mulatta (Rhesus macaque).
OH   NCBI_TaxID=10090; Mus musculus (Mouse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Medium plague;
RX   PubMed=16103157; DOI=10.1128/jvi.79.17.11062-11070.2005;
RA   Fata-Hartley C.L., Palmenberg A.C.;
RT   "Dipyridamole reversibly inhibits mengovirus RNA replication.";
RL   J. Virol. 79:11062-11070(2005).
RN   [2]
RP   IDENTIFICATION, RIBOSOMAL FRAMESHIFTING, AND DISRUPTION PHENOTYPE.
RX   PubMed=22025686; DOI=10.1073/pnas.1102932108;
RA   Loughran G., Firth A.E., Atkins J.F.;
RT   "Ribosomal frameshifting into an overlapping gene in the 2B-encoding region
RT   of the cardiovirus genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:E1111-E1119(2011).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Ribosomal frameshifting; Named isoforms=2;
CC       Name=2B*;
CC         IsoId=P0DJX8-1; Sequence=Displayed;
CC       Name=Genome polyprotein;
CC         IsoId=P12296-1; Sequence=External;
CC   -!- DISRUPTION PHENOTYPE: Knockout mutants display an attenuated small-
CC       plaque phenotype. {ECO:0000269|PubMed:22025686}.
CC   -!- MISCELLANEOUS: [Isoform 2B*]: Produced by -1 ribosomal frameshifting.
CC       The N-terminus is translated following a ribosomal skip event.
CC       {ECO:0000269|PubMed:22025686}.
CC   -!- SIMILARITY: Belongs to the encephalomyocarditis virus protein 2B*
CC       family. {ECO:0000305}.
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DR   EMBL; DQ294633; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   Proteomes; UP000008663; Genome.
PE   3: Inferred from homology;
KW   Ribosomal frameshifting.
FT   CHAIN           1..129
FT                   /note="Protein 2B*"
FT                   /id="PRO_0000423151"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          91..129
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        112..129
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   129 AA;  14191 MW;  5998E60AF0C8FB98 CRC64;
     PFTFKPRQRP VFSDSRSGSV INGSNPTAER LGQQSYGISL YGFARCQRGR PKSNEDYKDV
     KFSIGCMGKC KRNIEQPGVL ETTLKQMCAT DCRDDDSSDA SGPLDAALLG SLDSSRDHKP
     DKPVRRNSS