ID   ALTA1_PLETA             Reviewed;         137 AA.
AC   Q5EZC5;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 28.
DE   RecName: Full=Allergen Ste b 1;
DE   AltName: Full=Alt a 1-like protein;
DE   AltName: Allergen=Ste b 1;
DE   Flags: Precursor; Fragment;
GN   Name=alta1;
OS   Pleospora tarda (Stemphylium botryosum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae;
OC   Stemphylium.
OX   NCBI_TaxID=120510;
RN   [1] {ECO:0000312|EMBL:AAT66565.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BMP 0360 {ECO:0000312|EMBL:AAT66565.1};
RX   PubMed=15670710; DOI=10.1016/j.fgb.2004.10.009;
RA   Hong S.G., Cramer R.A., Lawrence C.B., Pryor B.M.;
RT   "Alt a 1 allergen homologs from Alternaria and related taxa: analysis of
RT   phylogenetic content and secondary structure.";
RL   Fungal Genet. Biol. 42:119-129(2005).
RN   [2]
RP   PROTEIN SEQUENCE OF 35-96, SUBCELLULAR LOCATION, MASS SPECTROMETRY, AND
RP   ALLERGEN.
RC   STRAIN=FMR3952 {ECO:0000269|PubMed:21504377};
RX   PubMed=21504377; DOI=10.3109/13693786.2011.576350;
RA   Gutierrez-Rodriguez A., Postigo I., Guisantes J.A., Sunen E., Martinez J.;
RT   "Identification of allergens homologous to Alt a 1 from Stemphylium
RT   botryosum and Ulocladium botrytis.";
RL   Med. Mycol. 49:892-896(2011).
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250|UniProtKB:P79085}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21504377}.
CC   -!- MASS SPECTROMETRY: Mass=15100; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:21504377};
CC   -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE.
CC       {ECO:0000269|PubMed:21504377}.
CC   -!- MISCELLANEOUS: On the 2D-gel the determined pI of this protein is: 4.0,
CC       its MW is: 17 kDa. {ECO:0000269|PubMed:21504377}.
CC   -!- SIMILARITY: Belongs to the ALTA1 family. {ECO:0000305}.
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DR   EMBL; AY563274; AAT66565.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5EZC5; -.
DR   SMR; Q5EZC5; -.
DR   Allergome; 2636; Ste b 1.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR032382; AltA1.
DR   Pfam; PF16541; AltA1; 1.
DR   PROSITE; PS51895; AA1; 1.
PE   1: Evidence at protein level;
KW   Allergen; Direct protein sequencing; Disulfide bond; Secreted; Signal.
FT   SIGNAL          <1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..137
FT                   /note="Allergen Ste b 1"
FT                   /id="PRO_0000320211"
FT   DOMAIN          28..>137
FT                   /note="AA1-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01243"
FT   DISULFID        23
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250|UniProtKB:P79085"
FT   DISULFID        67..82
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01243"
FT   DISULFID        121..133
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01243"
FT   CONFLICT        39
FT                   /note="S -> Y (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        52
FT                   /note="S -> G (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        60
FT                   /note="E -> G (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        77..81
FT                   /note="DKFYP -> HKWYS (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        87
FT                   /note="S -> F (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        91..93
FT                   /note="AFQ -> SFD (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
FT                   /evidence="ECO:0000312|EMBL:AAT66565.1"
FT   NON_TER         137
FT                   /evidence="ECO:0000312|EMBL:AAT66565.1"
SQ   SEQUENCE   137 AA;  14790 MW;  4420CE1B8F63358E CRC64;
     ALFAAAGLAA AAPFETRQDY ASCPVSTQGD YVWKISEFSG RKPEGTYYNS LSFNIKATNE
     GTLDFTCSAQ ADKLEDDKFY PCGENSSMSF AFQSDRNGLL FRQDVSNDIT YVATATLPNY
     CRAGGDGPKD VICQGAS