ALTH1_PLAF7
ID ALTH1_PLAF7 Reviewed; 10287 AA.
AC C6KTB7;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-SEP-2009, sequence version 1.
DT 23-FEB-2022, entry version 70.
DE RecName: Full=Putative E3 ubiquitin-protein ligase protein PFF1365c;
DE EC=2.3.2.26;
DE AltName: Full=HECT-type E3 ubiquitin transferase PFF1365c;
GN ORFNames=PFF1365c;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
RN [3]
RP SYNTHESIS OF 7581-7613, AND POSSIBLE CANDIDATE MALARIA EPITOPE.
RX PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT "Rapid identification of malaria vaccine candidates based on alpha-helical
RT coiled coil protein motif.";
RL PLoS ONE 2:E645-E645(2007).
CC -!- FUNCTION: Putative E3 ubiquitin-protein ligase. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.26;
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine as
CC determined by epitope response in sera.
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DR EMBL; AL844505; CAG25094.1; -; Genomic_DNA.
DR RefSeq; XP_966264.1; XM_961171.1.
DR SMR; C6KTB7; -.
DR BioGRID; 1210395; 10.
DR IntAct; C6KTB7; 9.
DR STRING; 5833.PFF1365c; -.
DR PRIDE; C6KTB7; -.
DR EnsemblProtists; CAG25094; CAG25094; PF3D7_0628100.
DR GeneID; 3885722; -.
DR KEGG; pfa:PF3D7_0628100; -.
DR VEuPathDB; PlasmoDB:PF3D7_0628100; -.
DR HOGENOM; CLU_222710_0_0_1; -.
DR InParanoid; C6KTB7; -.
DR OMA; RIGCEEC; -.
DR PhylomeDB; C6KTB7; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000001450; Chromosome 6.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR SUPFAM; SSF56204; SSF56204; 2.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50237; HECT; 1.
PE 1: Evidence at protein level;
KW ANK repeat; Membrane; Merozoite; Reference proteome; Repeat; TPR repeat;
KW Transferase; Transmembrane; Transmembrane helix; Ubl conjugation pathway.
FT CHAIN 1..10287
FT /note="Putative E3 ubiquitin-protein ligase protein
FT PFF1365c"
FT /id="PRO_0000371259"
FT TRANSMEM 1821..1841
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1860..1880
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1900..1920
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 5058..5078
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 5106..5126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 5552..5572
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 5716..5736
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 5815..5835
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 47..82
FT /note="TPR 1"
FT REPEAT 631..665
FT /note="TPR 2"
FT REPEAT 2116..2145
FT /note="ANK 1"
FT REPEAT 2141..2175
FT /note="TPR 3"
FT REPEAT 6004..6032
FT /note="ANK 2"
FT REPEAT 6051..6084
FT /note="TPR 4"
FT REPEAT 7347..7380
FT /note="TPR 5"
FT REPEAT 7577..7610
FT /note="TPR 6"
FT REPEAT 7809..7839
FT /note="ANK 3"
FT REPEAT 7845..7875
FT /note="ANK 4"
FT REPEAT 7880..7917
FT /note="ANK 5"
FT REPEAT 8782..8815
FT /note="TPR 7"
FT REPEAT 9550..9584
FT /note="TPR 8"
FT DOMAIN 9938..10273
FT /note="HECT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00104"
FT REGION 566..592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 740..823
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1221..1251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1599..1670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2070..2112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2854..2945
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3087..3113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3303..3344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3561..3599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3942..3998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4076..4157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4695..4716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4886..4972
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4984..5051
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5848..5917
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6495..6527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7123..7147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7183..7217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7571..7590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7653..7712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8208..8300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8413..8448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9795..9818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9913..9979
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 740..761
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 762..813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1599..1633
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2090..2112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2866..2930
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3090..3113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3561..3597
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3942..3976
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3977..3995
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4888..4972
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4984..5029
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6504..6527
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7128..7147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7653..7667
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7689..7707
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8208..8278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8280..8300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9801..9818
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9913..9928
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9929..9979
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 10241
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 10287 AA; 1206017 MW; CAA2BA46EF1C6876 CRC64;
MKDLYSLYED ISENDKIIIS EKLKNLLNYF QDKNKSYVSE FVVVSRTRFF KSISNYGEFL
LLQSSSRVIS SYEHILRLLH QAKVYLEFVR CLKLNNCSVI DNEKYEEEIS KFINYLESKR
KKYYYHICQI LIKFIVSSLS DNTIDNKFME KEFDIEEDNI DGYEKNVNDI EIKNEEYNTS
YESQRVKDNN NSNYNNNVNI WTINDNDEKI VMEPFDELEE YGNYLYNVLN QMDNKSWKDK
NHAEYLKVIS LNDAIIKEDN DKNKNSENNN GLTNTSNITN NMILLPKYLE NVRNCIYNHQ
TKSMLEVKSM IEHAMSDNIK APLFKTGKIV SEMLPSPNYE KYWSTTQPEF SNKIDTSLVQ
NMIFKFFNLQ KNTTPVDNMT PTNYNIKFYD IFKIILKGIY SIKCENEETH IFLNQLLNKT
KKKKYPFNYN NQLLDKNVKT DDLYNYLLLP LHLYNNTHEI CEGILKYTIY NNDLVLTLKI
VDTFLTISVY ENSLKDLVHL LNTLAECIIL PYLRTEIKEN IKHDTGDKDI YRTGTLCKNF
ETELTNEFNK ISDDNNNNNN IGIIDTNKSR DNINQNTNTN NNNNNNNNND GDRFDDDQFF
DNFSNLHKLI CKIPLHEYES LKLLELFSLQ YPMFLKIQNK PQRCLKDISK PCEYYSNTLP
IYGSYIFQIV VSFEIDNSIK VLDELGSKCK ICFQLTNDNM NDENSTDITV SDDNSNIPNK
EYNFLEINFQ QNHMYTKYNK SSVKEEDEIE KSMKAKSSTK SNDETNKANN NKNNNNNNKN
NNNNNKNNNN NNKNNNNNNK NSNNNNNNNN DTFEEYEKNN KKKKKNVQVN KLINVYDITN
MNTIVFDILI DQGCFSSETN VNNVTNDNGK IVIYSNGRHL LTSNINKKII GFNEKKGLTN
NNIKLKVFTS RTCSFEFPKE CYWSSAFVQE LVNRKLIPET NQNFLLKNPI NIIELYNKVS
IALNRYLYRF CEWNNGDYKR IIENDSCYTL YNNIDINTFE ALIKYTENNN KILKKLYTLS
KNCALDKENY MENNKHNINY YFSLSPVKYH VRKYREYIYE WNQTSDSQIC ALSILKLYLK
NNLDVNDGRI EHNEKFYCLS ERLIKSFLKI IKLKTPFINR EDFYVNNNYE MEELDLDGSL
WLLRRNVFQI LLDADKIIMS NIFMRINIET ILNLLKFFSD NNSLDSDMIL KLLKSLEEKG
ILEIMMKRML STPCKDGTQY NNSNYNDNSH YTHNSLKSQN ISSSTYSSSS SSSNLYNTNA
ENFNDIYTNN NGEEKRKKRK YYEENMHEIQ RYEKRKRNNK SRIIDTTHFG VFVEELMTLI
EHQTNNAINT PVVNHIEESD VFMENKACDV IHKLCSFYND EIKSEVFLRN YNHFNLCIKI
LNEIKKKNNH VSSASEVASI FLRGVVLMLT TYILTIATEY ESTKTFLYKP VIPFYNLHNE
MLKKKKDIHV YHGEEIKQMI SMNSKSMKDR YNNQFNQYGS NNKSSNLTNQ NIDILKCDME
DVSSCNSRYS SFINQNWELE YNKKIKKNNS ISNNEYNKKG DVESRDHANS WIPLISNQND
GSIDGVIIHS DDSSSQSFLV SKRKVYTFGR KSFESVNMYV DDNEEDEGEE DKSEDYEYCD
DEQQNDVYED TEEESDNYHM RKERRVHQKK KNSKVSINKK TNNSLSDDNN YSSDELEEFY
LRKNLLDLCD NNNNNNNNDE PNNFKSQLNE ILYKLSKKKK YARNSKKLKL LKKKIIKYKN
VSKKLNFIFS LLEEILKIML SVGLRVLSSI SYHYLYEKNG IYKFINIFGS NIIRSNLRDK
GSFLELCENM IKPKCLTLLQ ACTFIISGII PCLGYVTTLF VDKKANKYFY IKELNNYLSL
KMALNIWPMF LKITLQGLLT SRHLSSEMSV HKDNLHPIAE CCISITSLAT HFLTLFTIMI
DNLSRYEIYF NLKKGMNTLG NNYPIPLILI NSAKYIRIES KKNKYYDIEK AIRTILLQLT
DCSVCDYENY VFNHYMVPQS ISSFLYATRM NNDSNLENEH SSNNINAHET DYHDISINKN
KALGNEMVKT YQSMYEDDYE QERIGIRSRS RRGIPLKKKS ERNNSKEENV NNMDHNNNNN
SNSNNNNFFH RGSYSTNPRN NNITCDRKNM EFLKKLMKND HDAVQCLGKA YSVFHKNFER
AQIAFVAVFL HLTGYKHGQI KGPHQNYNSA KNNNDNKNDH IIIEDSLENK KIKIACNLAR
QGVIDLISKS QASQYHKKSI EEYNTSSKNK KCKEEIQEQM SMEHFEGNNK RMNNVKSGSH
NDFKNLVRES HQNINEIDPD DNNKSNVYSS IEQVNDLPLN KKKSPILHLS SDLDEKNDLN
FCNFSKEELN YVNDVHPNGE KSSHNNKSNE FLAMDSIQKK REKQIEKILQ KCEWIINTYP
FGLCPVSVKE NISQEWDEHF VFMRRNSYDI PITVRKMYSD RSNYQMLHEV ATMPAVAVEP
SVSSLSYLDQ LFSHQNKIND DKLECIQFST ENIFGKSTTK NLFLLKKLLK TYKRNVCIRE
PSNQLDTNKY DKICLENNKQ FHTYICNNKN VNFSNSCASC DSGEGNYYND ESNYYMNFHF
SEKNNDHLSN NSLVLKYNNL CKTNNLEKFG ELWLNARSTK NYVYHNDQDV QHIDEFNSNL
MNYKPECFLF SLKSVDENDY IMRNENMNNV KWDPTGSHIT KYTNSMFDYY DNASDMNLSE
LHGKFNAFYK PQKIIRSMNK QEFLPALYQE EMLRNQPYHT TANNNTTNII NTTKKKSFPS
FDYFRNKYLP NNSIDFTINN AVDHTIDSKD MLQLKEILKF IMNDTDLETV LNIIRIEQLT
SLCRYLISRS LKSMLCAGIF GGIKNPIVNM SKKNLSSNKR SQKGYNSNSD DIKKKKKSNC
NENEGSLDKY NDKEKKNDKI NNGDTKNSDD GKIDMDDKKY YNDDLKNSDY SKNNESNYLS
LSKEPDDMLL PSPNYEKGIS TCVKKNRFSV LSEAYKEENL LVNQRKYKNL DLNQKIFKND
KRKKGIFEQW RQKSTKSMQW PVILDLLVPS FSRGSYNECN RMISNMESSL FSVQNYGWML
LKLLHIIIIK FRSLTPLKTI MREIDEKNRN SNNNNNNNNT NNSNNSNNNN NINSHYMNQW
NGSNIKDPFE YHYWFTQPME YALSFTLTDI TKSICIWYLR YNRKLIMNSS SFSEIIKNSM
NTLWIESVLR LIALQICLGV KPLNDSRYVV PFLYHMFTIC QPLLREVHIS GDYLKKKLLV
GNKILYYSNK NNSFLQVKCS YCHKSVCMSS RKMSSKMSPM ETPLKSIRKG NSSEVSSKIS
YLNGHTYSNN DNRDNYDDDN CDNYDNYDND NENDNCDNSK NDRGVKGYIH SERVQKKQKK
IKHKIIKMKM YNLSEQEHEE ILDNVITGII IYHQTLQNNN QHINKMIILQ NLKGFKIKEE
YYTNENHYWA LCVQQYKNSP LYTLPLKNLN KCIKHNNRNI FQTTKMNESD DTSCYYWSVS
GDPVYNIYGN AKSISDVQLE ICAHKKYDSN VRSYLKKNNF ELEFSINTHM NDVVNIWIKR
KSIIINKELI EITDHHSIPL FSKGKQKKEM QENEDEKIKN KGKNKTKTND DKKKNSSINN
NNDCYDINYK YDTYNHEEND GSHKEENKKY SNENENVEYL SEHFCDCMKV YTDQDYSNED
YSNDYNYNCD NYKNMYSDDK KNRDLYDHGD NNLNYKKLKL ISWNLIQTIL WGILVSGENV
QMENSDQVIS ESTTKYIKKK ICNIQDEIDV NGNNHNDYKD YKYAFYKLQR KSLIESVLKM
IMSVLIKLCN IVKLYNDLTK NKKGSFYICI NNTKISMKQV KDCERMITDF MYALIKCVQN
SSTAAVTLLR CFLFGQDNPT YRFRKLNKIQ INCKFYRLIT ECIKKAPSDA DDISIFFNTY
LDKKKTLMNN DNDKINTKTT KKTKKEKTTK CYKNEMYDEK ATMENNKKNN MGDLKWNEGE
APAHPSKDKS KHYNDNNNNN NDDNNSNNNN DYNNKDHINY PDDYVYNNRC IKYKGMDLKM
SNFFFKYYDT NMKKNYNESK IHGFFLLRCL PPIKMFPKQL VIQETQKLFQ NENNFLFNSK
KDGSSNNDKN DNSNKNRNNY NNNDDNNNND DNNNNNDDND DNDNINNNYN NNNNNNNRNN
SNSNNSNNSD NNNINYYYNN TDYQIGEHNN MQIHSSSKEN TLYPDDHQNV DISTTTNEGN
SQCNSINNIL GLIPRISYRN HPFDDLPQSE FFMSSRPSDD FEAHMEGRVL RVLRGLNLGG
VVLCLAPLTF PALHVGPNEV NDIINFRIQT RGRFGVTVAP AECVLSNVSE VFDRNDVVGF
RTNMCPPFRH DVFAANVQYE LGDLLSVKFN VEDQQNQKCL RTELMVSGVS IGSVLEVLFE
ADSQIEFERR MNLIFIFQDP LTIVYEGPTF TMQYVDPNKN NANNFRNDKK NADEEFLNEL
YSLSGYDKKN FKKELRKIRM KKNEFYESVK LYQSILESDN EILKDLKHEV IIRMNTSLTN
IVSYFKHLSS NGVIFNSEND YYYWNDTDDT LLRKITTKKK KKHLYNMNCN NKMNEKYELI
SLDTLLSNDE KKKKMNNMNI LNNPNFKTKG GKKKKKINIH LSNDKEEDKD EEAKYVEGIK
QEKHTYYDYS NNSLLYNENK DNSVDNYYSF GNKEDGNRDI FSYSEEKHYN IITYDNSQIT
SSDKNNDPNR EKILEKKNFQ DDSIMSNRQS DNKEEGTSFN LYADSSIYVN MNKKYKSHVD
IHKTIREVLS IICVLGLNIN GEPKENKQEK FSNDTNYIFD ELPWLTSLSD LKNSVTYNLD
RKCLELFFCN LVDIICMDVF LGSILNFVTH NINENNQRCT RDKHNIVSFK HNKNYKKVIQ
KTSELDSECY PNEEYNDEFF ENRKGSPYFP SRSKNGNINS DRRKNYNIQN SDNSNIGDSE
LNVNVNDNDN SSCGSNSKDS LNVHARNVGT DINSSSESGN TNSNNENSLR NSIFMEENET
IESYRNKTKR SLSKDKNAGD LSNDNTEEIY HNNRYKKEKN KDEKNKIKKN KSYKNKTHKN
KKQKNKSSNA DKMNKNSLYG YTLCLIGTKS IMCCCIILRT LLEMNSDGYY EPNEKMYASC
KRLLNFIKLF FFIDIGISDV LIKYFAEKNK MMDMNFLFDK RKQTQNGNNN SEICSTSSFL
NSFVKNTNGN NKKKNNNHND NHMDCMNWKE EVVFYNQKYH DNMHTKDLLN NKEDNQSSYI
STNGKNKDTK DAVQNEYINI LEIVNYCGIP NNFLEYFDIS TPTIKNQQVI AQNDSFDLWI
YIMNLLICFN SQNKYSLSFP QSINQLSENS IKNTLFDLEY SKFYFSNKIL RKSVKFYASW
LLKKYIIDMT CVMASLVPKL FIDELKTNLM KINEGVRSGE EIENMRNVQN KYTNSQDSVN
YSSANTKEMN HKTIVPKCCF ENEKTKLDHV VNNKEGHQMG FDSFNDKKDG LHNIHHAKSC
EEKNNTKSNS YNNYNNYDNY NNINKYSCYN DKEEYQHELL CINNDYTHHN KTQGNFNDKL
MHAKKKYNSK YRKVNKVEHI GQLLNAHLRN KEEILNIFSI MYLFRICIYY LGRSKDFRKE
DYWQNFQGQL RNAKIKENVY KLLNEKSCKS SLLFGWQRIF YQCVVSWDDE KLVDQLLIII
QSELLYHLIG SVAQSMSQKR VKVEQFYAIS PSVHVAHWMI DTFVRHPLCP SKIRSCCITP
MTVTSLFGLI MNGNRLPIFL GIDVCRLVYW CCVVYILQNN QMHKHYKKLN NIDILTQLNI
TMEEPLNNDL EYTTCANQKK MITKNYHNTK SNKQHNNYFS TRGKMQKVKC NYYSFLSYVF
HCVNICGSSV INQIISFNNN DVGYKNNVNK NKGNDNVSNN NNNNNNNINI NSSSNNNNNN
SSSNNNNNNS SNNNNNSSNN NNNSSSSNNN NVRNSNNEHV NNIIDNLNNN INDILNCIQN
SSNNRVLNNH FSGISSVSNE TIYNLNITNR RNSHNISSNN INNTNTLQEN TETNNTSNVN
NLGGINSLYV NGTNGNLKTD KILLHNFSNF DLMENKEPSM YNSMKMNASL LVHYFACAAY
YIKRADVYNI MNYYNEHTHA NFKQYCLYLY VVDHVSKIYS KHIKRKINLK KKGGKKDDQL
MTSSFFSDLM KKDPNEKSHM CYDDYTNNKY DNNNNKNNLV NNENELIVRK DSKISSKNYS
FNSDYKHADK TKCRKHTYDE SYKGQYPELF VDDVLHIPKK LSANIIINMN EKIHHISSSN
SNTIKIKIRD MFVLPKQNDK SFIHKGIFST HHNKPFYDKE DKYMFGEKNI VEHKNKQKQL
YADHSNHQNK KHFTYNENKD KFNDKSNCNL KQKINRLNSE ENERIEKINQ KNFKHPNIIF
SADNSFNYIL HEIKFKKIQE FVYLNSNVID EKVDLDTIEK ITLGSYIELT DIYNLPGSFF
LIGNSELYSG SSNLCSSSFT ISLILVDNNA DNMSDGNFNN FPNIEIGVIN RKKYFEIKLE
EDQNEDEDKI EIEIEEEKEN ENEKEVEKDE NVHDEKDKVE QIEHEKKKEK DDKEAWLLHY
DDGKDTNVKV KKFSNCRISK NEEDNIAYRL RNKELLGEKN ITSKNSKFLY DKNVVDESLK
CTRKNEDEYE GTEKRHSSNI PTDINKIAHV SLTKYINNEK IEKSKTRGGK RVQNVVEKLR
NTLNDNNIKE DILNENHNKN NININSNINS NNNMMRGKMF HENLCDINMK NLGSNFYHSK
YADLNKTNYI TLNISDGNVN SKGFDCTDNN IENMKELLTN KMSGILNITV QIVGKKILWF
ANNILIFCKD FSYEMKEFLP FLKVSPIESK KIPKNNGSNK PSVHMKFTEM NEKTFVSPLS
NFYFKFENMH KLKYENDCIN TNKLWSKCLW KPVFFILPDV NNNSDNNVDV PGTSTHDLVS
TKMNTHVNVN NNNMANNTND TNYLNHSIIK KKMVPSIIPQ SSNEIVIKYN KYHNTYGHIE
YEDQFANTLF VSPNIQIKSE PINITYYMYC KNLQGKKCKL LCMENIKNIR TISIKNYYGF
INLCNQYKHN EKPTSSSMEQ KNSNNNVSYS HHNMYQVQQK PYSKIFDTRK NVESENSNNK
ADSILKQHLN RIINKSEDLR INNKGTLDIC NKLLLSNECK TNEKKKKTGS NNIGSNTNIH
ELSDNNRGQH TSYYHEQLLS ESLSKNVIHS NYINDYFTLN NDNKNNTSSS SNNNNNNKNN
NNNNDNNNDN DNICSNSNNN VHIKYKLNQI PKIRKHIHHN IKYSSIQEIN DNSHYSNKNI
IEEKKQKENS NDMHNPKKNE GHYYIADPSN EKEILYDNKN NENGYSNNFL DDNNALHKHV
HNKITLKGSN TYYDMDKIKD KQIEYFSNDS SNYSLYYIGC KEFKLCIDSY DSIFPAKPFI
FNCTVNFKEE ENYYHKKNYL TNSVGIIWGI YRWLWKSNGK FICPLRLPLC VSEFPSEKIE
ECEIDVVGYK SNDNLCIEFQ PLYQCLLFYK NGTYQFGFKF DTFYNYRNLK NTFLSEHNGD
MNMDRVHQNI SKLSYSSSIS NANFNDNFFV KRFVHNKYEQ VSTEKNDLQK MSKKKDDKIN
NYDDNMMNNY DDGNNNNNNN DSMNNHKDDM NNYNDNINNY VESMNNYDDI MNKGHVVTQN
NLTLNSEHNT KVNISNFFPL SNMSSVSNMY TISNERKSSN KGNGTNNVVK ARVERRGKYK
GMNGININND NDRDEDNNKD KDDGNHDNVN NINSFYNKDR MISYDNLKQE KQNDTVMRIK
NHVNMIKLYN CLLLNDCENV SSILINNPEL LTKSNENMSE ISFEHYYQMN SDDFPYELIS
SMKNIMHEKY LTPLMLACRI GCEECVQNII EKGKVNPNKS CHRIEKETPL MVAAQYGHSR
IVCMLICVYG VQVNKKDIKG NTALHKILLN YSNTEGKKNS TIKIVQLLLK LGADLTIKNK
KGISVEDLVQ KKLIKNEKIE NLLNIWITLI IKNKKKHEGR YIPRNIIPGL LSNCSIVVGF
PKGINGNVPN ECGVKINSFV VGGEELVNVR YHKEKPTKHT FDNNYDNNYD NNYDNNYDQD
GGNNIYNNAH SNVYNNGDYK NNLNKDDHPC YINFNYDKLN YNYNKWRVRT KEEEYYSCDN
SSSNSSISKF GNLEKKIIED HEKYKFSKYG GYPNGLCYKG EKNTHYNKGF EGMNSLEFDA
FSGCKNMYED TYDKENEEKL LYNNIKDNGL KEIDQEINHS NDNIKAFLKD DDEKDDDEYQ
KPYDKKVINK NKNDNYDKND NYDKKDNYDT NDKNDKNNCD DNIILSGGKK DKRNKKVMNT
NSSGRRTISK NSPNLSSAKN IKCSKTSTYN SEKYNSNERN SNLENHAIPI DHKDSVDETF
VFIEKQKRNN KINTNDSMTY NPVTHEKENI LNYILVHTYI DGKLGIRSAS NHDMETEHGM
DNIFETENKK NKALNSNMSN NNNNNNNSNN NNNNNSNNNN NNYNNNYNNN NNNCIYQEFY
MLRKDKKKRK HLILSNLQNN LFNYHDLKYS LIEFINKSGV FSDIIKGHSY LDSKKKIPKF
DELKNSLIEA NNELDIIKGF KKFLELFDFL YMDDRLKYFL NIDLRKNLEN SRNIVDLGYI
LLKIDSFCCI FNSFKLQWKD NSHEEWKKKL LKGIGILNEF SDIKWITDSY TIFKYEEEIL
ESASFIDKIL QNGNYMVFYN NLMNMIHDKN IHLKNGLYDS HIFNDMLKNI NIEHFNRDTI
LYDICSKQNI LKNYFIQERN KKYAMNNHDS RVINEKYKNY MNEYFVNKKL KGHSNNKDLY
LSMNDSEDEL IYSKEKKYKK HQTCDKYIYK SEMKEEMYNK SNELYNNSLN NSNNINNHSE
FYNNGVNRKG DHTYANEKDL SMTSLDCKNH MYGEPQPKDK TYKKGMYDEE RKQSMFNTSE
NTEQHDLINK VSGKEEDVRK PKQRNIRSKR LEDIIDKMYE DNDISNRENS KKNIDGLNNI
SGNGRIKFPS YSKNLLRYRN GNFLLNYSNN IFEKGREDES LNSHSPRVTS NLLASYSNER
HGIKLAFMNS GEQGKVMKHT YNDNVSNNVS NNNNIQGEYN HKGDVPHNKF IEKNHYTKNG
TNILSSLNKH NHLNTQEENN SLENNYSCET FCDEYDSEES EFELICEVHF TSKPNEEIMT
REQFNKMWPQ TLDMYILHIY DLISSYMDSP EKISLFIYHA FDMEKIKKKL PSKSSQLWKR
INMSLDDFIE EIKNVHNYTM RIIYQSNYKR YGMLPPNFKK YFTLSEECLK NIAKNKIIMN
MDYYKNYIYE ENKKMFLKII QDRIYLLNKF NIYFENCLPI TSILFNKPVI NLEEQGLRTL
ECPLCFFMSN DSYFPWTYKK RNTHLFQYNN NNNLCLVQKM RSELYDNNNL MSKNVSMLSL
YNNTNYSNND NNSIVGQSNY PIKVEGNHIN ENYKNCAEHN HYDYSLNKNY SNEKSIYVKN
SKQIDDIKKI KSGNEYIIMD SIQSLDKNST IVKKGSFFLN NGKGSYNSYT EIEDKDWLLG
NVENLNNHNI YPDNEINYKN NNHEDNNYNC YQNHLCGNES EEENEIFDCE KYCKNMYTSN
KMVLAMGSSD LPIQLSSYLF IKKLLKHDTC LKLWKECLKY ITSSSSEKSN LTLRIDRGMA
ATAKHIAHTM WYQSTYSLLN IDTDKLRGKP RDRPFMVVFV GEGATDFGGP FHEYLSSISR
EVMGKLSDSP DKSLPVFPLC IPCPNYTQAI GARQDTVIIN PQSTPYVVKE WDYIGEVDVI
DNLESFRWQI LNIYNSIKDI KKKLQKTAKD SYEDYKQKME ENGSDDGLEN IMPVKGKSKT
KGKYKKKNKS NKMNMGSDNI LKDGVHKDNN NQKGHKYDEK NICNDKNIQE MTSKEKMYFY
TSKKSVTFEK LEENEKMDYQ IENKYDYPFV CDACEYDSDI YEIINNASLK SRKLFMNKIW
KKKKCLDDEG DKNVLLRDPH ENENMRDDIR NNMNNNNNNN NNNNNNNNNN NNNNNNNNNN
NNNNNNNNNL NSIGGSKNTM TDGKKKNKFI IDYDEKTIKA MELAMYESLG RVMGMCVCIA
SALNICFNPI IWKKICGVPL ELQDLADYDF VAVEMLKTLK MLNSEKSNEW NMELKQSLGD
MTFITEDSGG NSIELIKNGM NIPINFDNLG LFIRLMTKCK MNESSKGIRH LLKGFSSVIP
LGRLRLLYDF KDVEHMVCGE REINIEVLKA HTWSNDLNIK DKLFTVLEEF TNEQLQSFLR
FVSGRSRLPT TKNDWYMIID VENPNKNISQ IDQRLPTAVT CGFRLLLPQY SSLDILKERL
LYAIKNCTAI DLDAYVVHDQ MQLMYGE
