ALX3_MOUSE
ID ALX3_MOUSE Reviewed; 343 AA.
AC O70137;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Homeobox protein aristaless-like 3;
DE AltName: Full=Proline-rich transcription factor ALX3;
GN Name=Alx3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=NIH Swiss;
RX PubMed=9676189; DOI=10.1006/dbio.1998.8921;
RA ten Berge D., Brouwer A., el Bahi S., Guenet J.-L., Robert B., Meijlink F.;
RT "Mouse Alx3: an aristaless-like homeobox gene expressed during
RT embryogenesis in ectomesenchyme and lateral plate mesoderm.";
RL Dev. Biol. 199:11-25(1998).
CC -!- FUNCTION: Transcriptional regulator with a possible role in patterning
CC of mesoderm during development.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: Predominantly in neural crest-derived mesenchyme
CC and in lateral plate mesoderm. Prominent expression in frontonasal head
CC mesenchyme and in the first and second pharyngeal arches and some of
CC their derivatives. High expression is also seen in the tail and in many
CC derivatives of the lateral plate mesoderm including the limbs, the body
CC wall, and the genital tubercle.
CC -!- DEVELOPMENTAL STAGE: Expressed in embryos from 8 days of gestation
CC onward.
CC -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR EMBL; U96109; AAC15094.1; -; mRNA.
DR CCDS; CCDS17739.1; -.
DR RefSeq; NP_031467.1; NM_007441.3.
DR AlphaFoldDB; O70137; -.
DR SMR; O70137; -.
DR BioGRID; 198080; 1.
DR IntAct; O70137; 1.
DR STRING; 10090.ENSMUSP00000014747; -.
DR iPTMnet; O70137; -.
DR PhosphoSitePlus; O70137; -.
DR PaxDb; O70137; -.
DR PRIDE; O70137; -.
DR ProteomicsDB; 281967; -.
DR Antibodypedia; 33780; 130 antibodies from 27 providers.
DR DNASU; 11694; -.
DR Ensembl; ENSMUST00000014747; ENSMUSP00000014747; ENSMUSG00000014603.
DR GeneID; 11694; -.
DR KEGG; mmu:11694; -.
DR UCSC; uc008qxf.2; mouse.
DR CTD; 257; -.
DR MGI; MGI:1277097; Alx3.
DR VEuPathDB; HostDB:ENSMUSG00000014603; -.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000160669; -.
DR HOGENOM; CLU_059011_0_0_1; -.
DR InParanoid; O70137; -.
DR OMA; GSHFYEG; -.
DR OrthoDB; 738339at2759; -.
DR PhylomeDB; O70137; -.
DR TreeFam; TF350743; -.
DR BioGRID-ORCS; 11694; 2 hits in 71 CRISPR screens.
DR PRO; PR:O70137; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; O70137; protein.
DR Bgee; ENSMUSG00000014603; Expressed in abdominal wall and 127 other tissues.
DR ExpressionAtlas; O70137; baseline and differential.
DR Genevisible; O70137; MM.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0003677; F:DNA binding; ISO:MGI.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IEA:InterPro.
DR GO; GO:0035115; P:embryonic forelimb morphogenesis; IGI:MGI.
DR GO; GO:0035116; P:embryonic hindlimb morphogenesis; IGI:MGI.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IGI:MGI.
DR GO; GO:0007389; P:pattern specification process; IGI:MGI.
DR GO; GO:0042981; P:regulation of apoptotic process; IGI:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISO:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR033211; ALX3.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR PANTHER; PTHR24329:SF340; PTHR24329:SF340; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..343
FT /note="Homeobox protein aristaless-like 3"
FT /id="PRO_0000048813"
FT DNA_BIND 153..212
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..49
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 343 AA; 36851 MW; 87900BF977FACD2D CRC64;
MDPERCAPFS VGPAAGPYAA AGDEAPGPQG TPDAAPHLHP APPRGPRLSR FPACGPLEPY
LPEPAKPPAK YLQDLGPGPV LNGGHFYEGS AEAEEKASKA ASFPQLPVDC RGGPRDGPSN
VQASPGPCLA SLSVPLSPGL PDSMELAKTK SKKRRNRTTF STFQLEELEK VFQKTHYPDV
YAREQLALRT DLTEARVQVW FQNRRAKWRK RERYGKMQEG RNPFTTAYDI SVLPRTDSHP
QLQNSLWPSP GSGSPGGPCL MSPEGIPSPC MSPYSHSHGN VAGFMGVPAS PAAHPGIYSI
HGFPPALGGH SFEPSPDGDY KSPSLVSLRM KPKEPPGLLN WTT
