ID   ALX4_BOVIN              Reviewed;         397 AA.
AC   Q4LAL6;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Homeobox protein aristaless-like 4;
GN   Name=ALX4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Wohlke A., Kuiper H., Distl O., Drogemuller C.;
RT   "The bovine aristaless-like homeobox 4 (ALX4) as candidate gene for
RT   syndactyly in Holstein cattle.";
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor involved in skull and limb development.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Binds DNA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC       ECO:0000255|PROSITE-ProRule:PRU00138}.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM048630; CAJ14976.1; -; mRNA.
DR   RefSeq; NP_001025475.1; NM_001030304.1.
DR   AlphaFoldDB; Q4LAL6; -.
DR   BMRB; Q4LAL6; -.
DR   SMR; Q4LAL6; -.
DR   STRING; 9913.ENSBTAP00000044572; -.
DR   PaxDb; Q4LAL6; -.
DR   PRIDE; Q4LAL6; -.
DR   GeneID; 594846; -.
DR   KEGG; bta:594846; -.
DR   CTD; 60529; -.
DR   eggNOG; KOG0490; Eukaryota.
DR   InParanoid; Q4LAL6; -.
DR   OrthoDB; 738339at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR033203; ALX4.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR003654; OAR_dom.
DR   PANTHER; PTHR24329:SF322; PTHR24329:SF322; 2.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF03826; OAR; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS50803; OAR; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW   Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..397
FT                   /note="Homeobox protein aristaless-like 4"
FT                   /id="PRO_0000244027"
FT   DNA_BIND        200..259
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          59..131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          175..204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           377..390
FT                   /note="OAR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT   COMPBIAS        92..106
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         186
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H161"
SQ   SEQUENCE   397 AA;  42484 MW;  C5B3CB18A9976EA2 CRC64;
     MNAETCVSYC ESPAAAMDAY YSPVSQSREG SSPFRAYPGG DKFSTTFLSA AAKGQGFGDA
     KSRARYGAGQ QDPAAPLESG AGARGSFSKF QPQPPAPQPQ PPAPQPHLYL QRGACKTPPD
     GSLKLQEGGG GHNAALQVPC YAKESSLGEP ELPPDSDTVG MDSSYLSVME AGVKGPQDRA
     SADLPSPMEK ADSESNKGKK RRNRTTFTSY QLEELEKVFQ KTHYPDVYAR EQLAMRTDLT
     EARVQVWFQN RRAKWRKRER FGQMQQVRTH FSTAYELPLL TRAENYAQIQ NPSWIGNNGA
     ASPVPACVVP CDPVPACMSP HAHPPGSGAS GVTDFLSVSG AGSHVGQTHM GSLFGAAGLS
     PGLNGYELNG EPDRKTSSIA ALRMKAKEHS AAISWAT