ALXA_CAEEL
ID ALXA_CAEEL Reviewed; 882 AA.
AC P34552; Q7YXC7; Q8I114; Q8I115; Q94159;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 3.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Apoptosis-linked gene 2-interacting protein X 1;
DE AltName: Full=Prion-like-(Q/N-rich) domain-bearing protein 58;
DE AltName: Full=Protein YNK1;
GN Name=alx-1; Synonyms=pqn-58; ORFNames=R10E12.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), AND DEVELOPMENTAL STAGE.
RC STRAIN=Bristol N2;
RX PubMed=9427532; DOI=10.1016/s0167-4781(97)00112-7;
RA Che S., Weil M.M., Etkin L.D., Epstein H.F., Kuang J.;
RT "Molecular cloning of a splice variant of Caenorhabditis elegans YNK1, a
RT putative element in signal transduction.";
RL Biochim. Biophys. Acta 1354:231-240(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [4]
RP FUNCTION.
RX PubMed=16236769; DOI=10.1242/dev.02076;
RA Shaye D.D., Greenwald I.;
RT "LIN-12/Notch trafficking and regulation of DSL ligand activity during
RT vulval induction in Caenorhabditis elegans.";
RL Development 132:5081-5092(2005).
CC -!- FUNCTION: Required for lin-12 degradation after it has been
CC internalised in the vulval precursor cells.
CC {ECO:0000269|PubMed:16236769}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=b;
CC IsoId=P34552-1; Sequence=Displayed;
CC Name=a;
CC IsoId=P34552-2; Sequence=VSP_016612;
CC Name=c;
CC IsoId=P34552-3; Sequence=VSP_016613;
CC Name=d;
CC IsoId=P34552-4; Sequence=VSP_016611;
CC -!- DEVELOPMENTAL STAGE: Expressed throughout development.
CC {ECO:0000269|PubMed:9427532}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U73679; AAC67305.1; -; mRNA.
DR EMBL; Z29561; CAA82667.2; -; Genomic_DNA.
DR EMBL; Z29561; CAD54152.1; -; Genomic_DNA.
DR EMBL; Z29561; CAD54153.1; -; Genomic_DNA.
DR EMBL; Z29561; CAD91697.1; -; Genomic_DNA.
DR PIR; S41034; S41034.
DR RefSeq; NP_001022713.1; NM_001027542.2. [P34552-1]
DR RefSeq; NP_001022714.1; NM_001027543.2. [P34552-3]
DR RefSeq; NP_001022715.1; NM_001027544.1. [P34552-4]
DR RefSeq; NP_499213.1; NM_066812.5. [P34552-2]
DR AlphaFoldDB; P34552; -.
DR SMR; P34552; -.
DR BioGRID; 41604; 41.
DR ELM; P34552; -.
DR IntAct; P34552; 10.
DR STRING; 6239.R10E12.1b; -.
DR iPTMnet; P34552; -.
DR World-2DPAGE; 0011:P34552; -.
DR EPD; P34552; -.
DR PaxDb; P34552; -.
DR PeptideAtlas; P34552; -.
DR EnsemblMetazoa; R10E12.1a.1; R10E12.1a.1; WBGene00007010. [P34552-2]
DR EnsemblMetazoa; R10E12.1b.1; R10E12.1b.1; WBGene00007010. [P34552-1]
DR EnsemblMetazoa; R10E12.1c.1; R10E12.1c.1; WBGene00007010. [P34552-3]
DR EnsemblMetazoa; R10E12.1d.1; R10E12.1d.1; WBGene00007010. [P34552-4]
DR GeneID; 176410; -.
DR KEGG; cel:CELE_R10E12.1; -.
DR UCSC; R10E12.1a; c. elegans. [P34552-1]
DR CTD; 176410; -.
DR WormBase; R10E12.1a; CE25075; WBGene00007010; alx-1. [P34552-2]
DR WormBase; R10E12.1b; CE00310; WBGene00007010; alx-1. [P34552-1]
DR WormBase; R10E12.1c; CE31853; WBGene00007010; alx-1. [P34552-3]
DR WormBase; R10E12.1d; CE34084; WBGene00007010; alx-1. [P34552-4]
DR eggNOG; KOG2220; Eukaryota.
DR GeneTree; ENSGT00940000163083; -.
DR InParanoid; P34552; -.
DR OMA; SEWIHHM; -.
DR OrthoDB; 550620at2759; -.
DR PhylomeDB; P34552; -.
DR SignaLink; P34552; -.
DR PRO; PR:P34552; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00007010; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR GO; GO:0016323; C:basolateral plasma membrane; IDA:WormBase.
DR GO; GO:0031410; C:cytoplasmic vesicle; IDA:WormBase.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0005771; C:multivesicular body; IDA:WormBase.
DR GO; GO:0043226; C:organelle; IDA:WormBase.
DR GO; GO:0055037; C:recycling endosome; IDA:WormBase.
DR GO; GO:0005112; F:Notch binding; IPI:WormBase.
DR GO; GO:0008022; F:protein C-terminus binding; IPI:WormBase.
DR GO; GO:0032456; P:endocytic recycling; IMP:WormBase.
DR GO; GO:0007032; P:endosome organization; IMP:WormBase.
DR GO; GO:0000281; P:mitotic cytokinesis; IBA:GO_Central.
DR GO; GO:0071985; P:multivesicular body sorting pathway; IEA:InterPro.
DR GO; GO:0033365; P:protein localization to organelle; IMP:WormBase.
DR GO; GO:0042176; P:regulation of protein catabolic process; IMP:WormBase.
DR Gene3D; 1.25.40.280; -; 1.
DR InterPro; IPR025304; ALIX_V_dom.
DR InterPro; IPR045251; BRO1-like.
DR InterPro; IPR004328; BRO1_dom.
DR InterPro; IPR038499; BRO1_sf.
DR PANTHER; PTHR23030; PTHR23030; 1.
DR Pfam; PF13949; ALIX_LYPXL_bnd; 1.
DR Pfam; PF03097; BRO1; 1.
DR SMART; SM01041; BRO1; 1.
DR PROSITE; PS51180; BRO1; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..882
FT /note="Apoptosis-linked gene 2-interacting protein X 1"
FT /id="PRO_0000058559"
FT DOMAIN 5..398
FT /note="BRO1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00526"
FT REGION 743..882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 751..772
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..812
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 842..882
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 359..742
FT /note="Missing (in isoform d)"
FT /evidence="ECO:0000305"
FT /id="VSP_016611"
FT VAR_SEQ 722..742
FT /note="Missing (in isoform a)"
FT /evidence="ECO:0000303|PubMed:9427532"
FT /id="VSP_016612"
FT VAR_SEQ 782..817
FT /note="Missing (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_016613"
SQ SEQUENCE 882 AA; 98264 MW; 8596D6D69A8786D5 CRC64;
MATFGFLSAP LKSTNEVDLV KPLTSYIDNV YNTSDNNRSD VAEAVQELNK LRSKACCQPL
DKHQSALDVL TRYYDQLVAI ENKIIISATQ NPVVFKWKDA FDKGSLFSSR ASLSLSDGSF
ERAAVLFNIG SLMSQIGAAQ QFHTDDEIKV SAKLFQQSAG VFARLRDVVL GMVQQEPTPD
LMPDTLAALS ALMTAQAQEA IYIKGHKDKM KATSMVKISA QVAEFYSEAQ KMMSKDIVRG
LWDKDWSAIV SGKNLAYQAL AQYHQSEVCG EARQIGEQLS RLAESLKLFD TAQKYLPRDI
TGIWDIYPSV SKAHAAAKKD NDFIYHEKVS DFRTLPTLPK AVLAKPTPMQ TPMTPSFRDM
FAVLVPVQVH NAMQSYDARK AELVNMETVR MREATQLMNG VLASLNLPAA LDDVTSTETL
PESLKLKSAK LKQNGGSSEI MRLFSELPTL YQRNEDILTE TSRILNEEKE SDDTMRKQLG
TKWTRMSSEQ LTGPLVTEIG KYRGILHTAS NADKMVKEKF ESHRQGIELL SKNESELRSS
IPGQTAHATG ETDTVRQLRQ FMSQWNEVTT DRELLEKELK NTNCDIANDF LKAMAENQLI
NEEHISKEKI AQIFGDLKRR VQSSLDTQET LMNQIQAANN TFTGEKTGSS TGAERERILK
MLAQASDAYV ELKANLEEGT KFYNDLTPIL VRLQQKVSDF AFARQTEKED LMRQLQLSIV
SGQAAKAVVD GVNSLVSSYL TGGTNAAQSP ANAPPRPPPP RPAAPSVESP IPPPRTQQSM
QATPGAPPQY NPYQQQQQPQ MQQFQQHPGY YQQPMPYGQP QPMFQPQYQP TFAAPYPTFP
GAFPSYQQQW PQQQQQGGFP PNPQFGQQNQ QQGGGGGANP FQ
