ID   ALX_STRPU               Reviewed;         327 AA.
AC   Q26657;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 2.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Aristaless homeobox protein;
DE            Short=ALX;
DE   AltName: Full=SpPrx-1;
DE   Flags: Fragment;
GN   Name=ALX;
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Martinez P., Davidson E.H.;
RT   "SpPrx-1, a sea urchin homeobox gene related to aristaless is expressed
RT   during embryogenesis.";
RL   Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC       {ECO:0000305}.
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DR   EMBL; D85080; BAA19774.1; -; mRNA.
DR   AlphaFoldDB; Q26657; -.
DR   SMR; Q26657; -.
DR   STRING; 7668.SPU_019338-tr; -.
DR   eggNOG; KOG0490; Eukaryota.
DR   HOGENOM; CLU_540067_0_0_1; -.
DR   InParanoid; Q26657; -.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..>327
FT                   /note="Aristaless homeobox protein"
FT                   /id="PRO_0000048816"
FT   DNA_BIND        212..271
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          152..214
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        159..177
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        178..208
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         327
SQ   SEQUENCE   327 AA;  37147 MW;  0D387C5C72AECFD5 CRC64;
     MKRKFEAPQI AMDSAVCCTP RTMDADNRWN ASVPSPERHR EAGMVVRESN AFGAVAPATR
     GLAGMTGSVG KCNDMMMNSG SWVDVSRMTD ARVKDNEQVF TSLIKTQVLD SSVEKKDKTE
     RSIHIWRPAL DGDEKETSKK DVDVEVSRAA RIWRPNDPQP EAHSTTATTM TMGDQERNES
     SRYVDDFDSD GDDEHLDEHG SNAGDRPTKR KQRRYRTTFT SYQLEELERA FCKTHYPDVF
     TREELAMRVD LTEARVQVWF QNRRAKWRKR EKLGLQPRLH PHPHFGPILG GPISDSNLVS
     SHLCRLACID RAHRQGLLTS PPPPPFV