ALY2_ARATH
ID ALY2_ARATH Reviewed; 1051 AA.
AC Q6A333; Q8RXZ0; Q9MA51; Q9MA81;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Protein ALWAYS EARLY 2;
DE Short=AtALY2;
GN Name=ALY2; OrderedLocusNames=At3g05380; ORFNames=F22F7.18, T12H1.35;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RX PubMed=15246533; DOI=10.1016/j.gene.2004.03.033;
RA Bhatt A.M., Zhang Q., Harris S.A., White-Cooper H., Dickinson H.;
RT "Gene structure and molecular analysis of Arabidopsis thaliana ALWAYS EARLY
RT homologs.";
RL Gene 336:219-229(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 232-1051.
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP INTERACTION WITH SNL1.
RX PubMed=19962994; DOI=10.1016/j.jmb.2009.11.065;
RA Bowen A.J., Gonzalez D., Mullins J.G., Bhatt A.M., Martinez A.,
RA Conlan R.S.;
RT "PAH-domain-specific interactions of the Arabidopsis transcription
RT coregulator SIN3-LIKE1 (SNL1) with telomere-binding protein 1 and ALWAYS
RT EARLY2 Myb-DNA binding factors.";
RL J. Mol. Biol. 395:937-949(2010).
CC -!- SUBUNIT: Interacts with SNL1 (via PAH3). {ECO:0000269|PubMed:19962994}.
CC -!- INTERACTION:
CC Q6A333; Q9SRH9: SNL1; NbExp=2; IntAct=EBI-2616358, EBI-2616294;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q6A333-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6A333-2; Sequence=VSP_039131;
CC Name=3;
CC IsoId=Q6A333-3; Sequence=VSP_039132;
CC -!- TISSUE SPECIFICITY: Expressed ubiquitously in vegetative and
CC reproductive tissues. {ECO:0000269|PubMed:15246533}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF27044.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAF64544.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ583496; CAE47461.1; -; mRNA.
DR EMBL; AC009177; AAF27044.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC009606; AAF64544.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE74227.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE74228.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE74229.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE74230.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE74231.1; -; Genomic_DNA.
DR EMBL; AY080604; AAL86288.1; -; mRNA.
DR RefSeq; NP_001030643.1; NM_001035566.2. [Q6A333-2]
DR RefSeq; NP_001118580.1; NM_001125108.2. [Q6A333-3]
DR RefSeq; NP_001189812.1; NM_001202883.1. [Q6A333-2]
DR RefSeq; NP_001189813.1; NM_001202884.1. [Q6A333-2]
DR RefSeq; NP_187189.2; NM_111411.5. [Q6A333-1]
DR AlphaFoldDB; Q6A333; -.
DR SMR; Q6A333; -.
DR BioGRID; 5037; 4.
DR IntAct; Q6A333; 3.
DR STRING; 3702.AT3G05380.5; -.
DR iPTMnet; Q6A333; -.
DR PaxDb; Q6A333; -.
DR PRIDE; Q6A333; -.
DR ProteomicsDB; 245001; -. [Q6A333-1]
DR EnsemblPlants; AT3G05380.1; AT3G05380.1; AT3G05380. [Q6A333-1]
DR EnsemblPlants; AT3G05380.2; AT3G05380.2; AT3G05380. [Q6A333-2]
DR EnsemblPlants; AT3G05380.3; AT3G05380.3; AT3G05380. [Q6A333-3]
DR EnsemblPlants; AT3G05380.4; AT3G05380.4; AT3G05380. [Q6A333-2]
DR EnsemblPlants; AT3G05380.5; AT3G05380.5; AT3G05380. [Q6A333-2]
DR GeneID; 819702; -.
DR Gramene; AT3G05380.1; AT3G05380.1; AT3G05380. [Q6A333-1]
DR Gramene; AT3G05380.2; AT3G05380.2; AT3G05380. [Q6A333-2]
DR Gramene; AT3G05380.3; AT3G05380.3; AT3G05380. [Q6A333-3]
DR Gramene; AT3G05380.4; AT3G05380.4; AT3G05380. [Q6A333-2]
DR Gramene; AT3G05380.5; AT3G05380.5; AT3G05380. [Q6A333-2]
DR KEGG; ath:AT3G05380; -.
DR Araport; AT3G05380; -.
DR TAIR; locus:2079747; AT3G05380.
DR eggNOG; KOG1019; Eukaryota.
DR InParanoid; Q6A333; -.
DR OMA; GGKFYRK; -.
DR OrthoDB; 132154at2759; -.
DR PhylomeDB; Q6A333; -.
DR PRO; PR:Q6A333; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q6A333; baseline and differential.
DR GO; GO:0070176; C:DRM complex; IDA:TAIR.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0051726; P:regulation of cell cycle; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0000003; P:reproduction; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR028306; ALY_plant.
DR InterPro; IPR033471; DIRP.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR010561; LIN-9/ALY1.
DR InterPro; IPR002999; Tudor.
DR PANTHER; PTHR21689; PTHR21689; 1.
DR PANTHER; PTHR21689:SF6; PTHR21689:SF6; 1.
DR Pfam; PF06584; DIRP; 1.
DR SMART; SM01135; DIRP; 1.
DR SMART; SM00333; TUDOR; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Nucleus; Reference proteome.
FT CHAIN 1..1051
FT /note="Protein ALWAYS EARLY 2"
FT /id="PRO_0000394046"
FT DOMAIN 39..93
FT /note="SANT"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 114..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 397..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 948..981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..293
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..374
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..416
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..576
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 581..605
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 951..981
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..77
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_039132"
FT VAR_SEQ 33
FT /note="R -> RK (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_039131"
SQ SEQUENCE 1051 AA; 117780 MW; A7C9FC65C5D69975 CRC64;
MAPVRKSRSV NKRFTNETSP RKDAGKSKKN KLRKKLSDKL GPQWTRLELE RFYDAYRKHG
QEWRRVAAAI RNSRSVDMVE ALFNMNRAYL SLPEGTASVA GLIAMMTDHY SVMEGSGSEG
EGHDASEVPR KQQKRKRAKP QRSDSPEEVD IQQSIGSPDG CLTFLKQARA NGTQRHATGK
RTPRVPVQTS FMRDDREGST PPNKRARKQF DANDDVAHFL ALALTDASRR GGSPKVSESP
NRRTELSDSS PIKSWGKMSR TRKSQSKHCG SSIFEEWMES SRERKLDSDK DTTLLMDMER
AGEMEAPRKG KRVYKKRVKV EEAECNDSDD NGEACSATQG LRSKSQRRKA AIEASREKYS
PRSPKKRDDK HTSGAFDALQ ALAELSASML PANLMESELS AQLKEERTEY DMDEKSSTPE
ATSTSSHGEK ANVEPDDSLL HAISSVENAN KRKSKPSRLV STDCDDVPTG KLQPQTSGSL
RKRKPKVLGD EAPAEFSQNK SINKKELPQD ENNMKSLVKT KRAGQVPAQS KQMKTVKALE
ESAITSDKKR PGMDIVASPK QVSDSGPTSL SQKPPNRRKK SLQKSLQEKA KSSETTHKAA
RSSRSLSEQE LLLKDKLATS LSFPFARRRC IFEWFYSAID HPWFSKMEFV DYLNHVGLGH
IPRLTRLEWS VIKSSLGRPR RFSERFLHEE REKLKQYRES VRKHYTELRT GAREGLPTDL
ARPLAVGNRV IAIHPKTREI HDGKILTVDH NKCNVLFDDL GVELVMDIDC MPLNPLEYMP
EGLRRQIDKC LSMKKEAQLS GNTNLGVSVL FPPCGLENVS FSMNPPLNQG DMIAPILHGK
VSSNTSSPRQ TNHSYITTYN KAKEAEIQRA QALQHALDEK EMEPEMLEIV KGSKTRAQAM
VDAAIKAASS VKEGEDVNTM IQEALELVGK NQLLRSSMVK HHEHVNGSIE HHHNPSPSNG
SEPVANNDLN SQDGSEKNAQ MPSELITSCV ATWLMIQMCT ERQYPPADVA QLIDAAVTSL
QPRCPQNLPI YREIQTCMGR IKTQIMSLVP T
