ID   ALY2_SCHPO              Reviewed;         658 AA.
AC   O74798;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Putative arrestin-related trafficking adapter C2D10.04;
GN   ORFNames=SPBC2D10.04;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-653, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RX   PubMed=18257517; DOI=10.1021/pr7006335;
RA   Wilson-Grady J.T., Villen J., Gygi S.P.;
RT   "Phosphoproteome analysis of fission yeast.";
RL   J. Proteome Res. 7:1088-1097(2008).
CC   -!- FUNCTION: May regulate endocytosis in response to extracellular
CC       stimuli. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
CC       Note=Localizes at the cell tip and barrier septum.
CC   -!- SIMILARITY: Belongs to the ALY1 family. {ECO:0000305}.
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DR   EMBL; CU329671; CAA21162.1; -; Genomic_DNA.
DR   PIR; T40107; T40107.
DR   RefSeq; NP_596223.1; NM_001022143.2.
DR   AlphaFoldDB; O74798; -.
DR   BioGRID; 276938; 21.
DR   STRING; 4896.SPBC2D10.04.1; -.
DR   iPTMnet; O74798; -.
DR   MaxQB; O74798; -.
DR   PaxDb; O74798; -.
DR   PRIDE; O74798; -.
DR   EnsemblFungi; SPBC2D10.04.1; SPBC2D10.04.1:pep; SPBC2D10.04.
DR   GeneID; 2540410; -.
DR   KEGG; spo:SPBC2D10.04; -.
DR   PomBase; SPBC2D10.04; -.
DR   VEuPathDB; FungiDB:SPBC2D10.04; -.
DR   eggNOG; KOG3780; Eukaryota.
DR   HOGENOM; CLU_008578_2_1_1; -.
DR   InParanoid; O74798; -.
DR   OMA; EYWTNDK; -.
DR   PhylomeDB; O74798; -.
DR   Reactome; R-SPO-844456; The NLRP3 inflammasome.
DR   PRO; PR:O74798; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0032153; C:cell division site; HDA:PomBase.
DR   GO; GO:0051286; C:cell tip; HDA:PomBase.
DR   GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005509; F:calcium ion binding; ISM:PomBase.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR   GO; GO:0072583; P:clathrin-dependent endocytosis; ISO:PomBase.
DR   GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR   GO; GO:0070086; P:ubiquitin-dependent endocytosis; IBA:GO_Central.
DR   Gene3D; 2.60.40.640; -; 1.
DR   InterPro; IPR014752; Arrestin-like_C.
DR   InterPro; IPR011021; Arrestin-like_N.
DR   InterPro; IPR011022; Arrestin_C-like.
DR   InterPro; IPR014756; Ig_E-set.
DR   Pfam; PF02752; Arrestin_C; 1.
DR   Pfam; PF00339; Arrestin_N; 1.
DR   SMART; SM01017; Arrestin_C; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Phosphoprotein; Reference proteome.
FT   CHAIN           1..658
FT                   /note="Putative arrestin-related trafficking adapter
FT                   C2D10.04"
FT                   /id="PRO_0000303890"
FT   REGION          21..107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          638..658
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..107
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         653
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
SQ   SEQUENCE   658 AA;  72732 MW;  40EB066BB970B4F7 CRC64;
     MRGELNIPAL SRFGKSISAS LHHQNGSSRD DNDSNPYENR SSNSGLNRRN SVFGLPSSGL
     SSRLSKPSLS SINNSNNSSS NTGGNVLPNP ALTPVRNMSN KPPLTWSPSS ANLFGTSKVT
     SIIGNNVSDV VPPVIKKALA SSHGGGMSLS IVLLEPVLYL AGFDLNECQI ENPALLRGAL
     VLRVAKPANI RGISLSFTGR SRTEWPEGIP VKGHDTYEDK VIISHNWKFY EPTMKDADAP
     QHGADVARLV GEQLPLPSSA AASLRGYSVF APGEYTYNFD LAIPNCFPES VEAKMGWVRY
     FLEATVERFG TFKSNLNGRT PVQLVRTPSP ASLSSSELIN ISRDWDERLH YELQVSGKSF
     RLGEVVPITF RFLLLDKVRL YKLSISVVES SEYWCRSRKF HRVDPKRRVL LAERSAKHQN
     TDNLFETPDE GDGLSSAVFN FNVALPTCLV KERDRLTFDT TYKYIKVRHR LKALLVLSIE
     NTENPEKRKY FEINIETPVR ILSCRCVKDS TLLPPYESSS QGDNQVLLPC PCRLATTHVE
     PTEVTAFTTQ SVLASSAPSA GRPAAAQISR PAQLFRIPST NPPPFDGDVC PPACNTPPPN
     YDELFDVLSS ISIQDCETDR ANDDTILNNR VRRSGTIREE APHRSLSRTV SRSFEIPR