ID   ALY3_ARATH              Reviewed;        1132 AA.
AC   Q6A332; Q0WLW8; Q6NLT5; Q9LIF3;
DT   18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Protein ALWAYS EARLY 3;
DE            Short=AtALY3;
GN   Name=ALY3; Synonyms=ATALY3; OrderedLocusNames=At3g21430; ORFNames=MHC9;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=cv. Columbia;
RX   PubMed=15246533; DOI=10.1016/j.gene.2004.03.033;
RA   Bhatt A.M., Zhang Q., Harris S.A., White-Cooper H., Dickinson H.;
RT   "Gene structure and molecular analysis of Arabidopsis thaliana ALWAYS EARLY
RT   homologs.";
RL   Gene 336:219-229(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA   Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT   features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT   clones.";
RL   DNA Res. 7:217-221(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-175.
RA   Cheuk R., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 564-1132.
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   INTERACTION WITH SNL1.
RX   PubMed=19962994; DOI=10.1016/j.jmb.2009.11.065;
RA   Bowen A.J., Gonzalez D., Mullins J.G., Bhatt A.M., Martinez A.,
RA   Conlan R.S.;
RT   "PAH-domain-specific interactions of the Arabidopsis transcription
RT   coregulator SIN3-LIKE1 (SNL1) with telomere-binding protein 1 and ALWAYS
RT   EARLY2 Myb-DNA binding factors.";
RL   J. Mol. Biol. 395:937-949(2010).
CC   -!- SUBUNIT: Interacts with SNL1. {ECO:0000269|PubMed:19962994}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed ubiquitously in vegetative and
CC       reproductive tissues. {ECO:0000269|PubMed:15246533}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB03056.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AJ583497; CAE47462.1; -; mRNA.
DR   EMBL; AP001305; BAB03056.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002686; AEE76508.1; -; Genomic_DNA.
DR   EMBL; BT011578; AAS46631.1; -; mRNA.
DR   EMBL; BT012245; AAS76732.1; -; mRNA.
DR   EMBL; AK230069; BAF01889.1; -; mRNA.
DR   RefSeq; NP_001319608.1; NM_001338532.1.
DR   RefSeq; NP_001325832.1; NM_001338534.1.
DR   RefSeq; NP_001325833.1; NM_001338533.1.
DR   AlphaFoldDB; Q6A332; -.
DR   SMR; Q6A332; -.
DR   BioGRID; 7029; 1.
DR   IntAct; Q6A332; 2.
DR   STRING; 3702.AT3G21430.2; -.
DR   iPTMnet; Q6A332; -.
DR   PaxDb; Q6A332; -.
DR   PRIDE; Q6A332; -.
DR   ProteomicsDB; 244465; -.
DR   EnsemblPlants; AT3G21430.2; AT3G21430.2; AT3G21430.
DR   GeneID; 821697; -.
DR   Gramene; AT3G21430.2; AT3G21430.2; AT3G21430.
DR   KEGG; ath:AT3G21430; -.
DR   Araport; AT3G21430; -.
DR   TAIR; locus:2089438; AT3G21430.
DR   eggNOG; KOG1019; Eukaryota.
DR   HOGENOM; CLU_007109_0_0_1; -.
DR   InParanoid; Q6A332; -.
DR   OMA; MYSQPCT; -.
DR   OrthoDB; 132154at2759; -.
DR   PhylomeDB; Q6A332; -.
DR   PRO; PR:Q6A332; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q6A332; baseline and differential.
DR   Genevisible; Q6A332; AT.
DR   GO; GO:0070176; C:DRM complex; IDA:TAIR.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0051726; P:regulation of cell cycle; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0000003; P:reproduction; IBA:GO_Central.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00167; SANT; 1.
DR   InterPro; IPR028306; ALY_plant.
DR   InterPro; IPR033471; DIRP.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR010561; LIN-9/ALY1.
DR   InterPro; IPR017930; Myb_dom.
DR   InterPro; IPR001005; SANT/Myb.
DR   PANTHER; PTHR21689; PTHR21689; 1.
DR   PANTHER; PTHR21689:SF5; PTHR21689:SF5; 1.
DR   Pfam; PF06584; DIRP; 1.
DR   Pfam; PF00249; Myb_DNA-binding; 1.
DR   SMART; SM01135; DIRP; 1.
DR   SMART; SM00717; SANT; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..1132
FT                   /note="Protein ALWAYS EARLY 3"
FT                   /id="PRO_0000394047"
FT   DOMAIN          42..93
FT                   /note="SANT"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          115..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          234..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          283..321
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          333..357
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          422..476
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          500..554
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          941..963
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1018..1059
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..43
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        116..130
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        131..145
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        430..450
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        457..471
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        508..540
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1132 AA;  127569 MW;  DF706F7BD38A031D CRC64;
     MAPSRSKKSK YKKKPRAKAV SPHKDEESMS KTKQRKRKLS DMLGPQWSKE ELERFYEGYR
     KFGKEWKKVA GFVHSRSAEM VEALYTMNKA YLSLPEGTAS VVGLTAMMTD HYSVLHGGSD
     SEQENNEGIE TPRSAPKRSR VKSSDHPSIG LEGLSDRLQF RSSSGFMPSL KKRRTETMPR
     AVGKRTPRIP ISYTLEKDTR ERYLSPVKRG LNQKGDDTDD DMEHEIALAL AEASQRGGST
     KNSHTPNRKA KMYPPDKKGE RMRADIDLAI AKLHATDMED VRCEPSLGST EADNADYSGG
     RNDLTHGEGS SAVEKQQKGR TYYRRRVGIK EEDAKEACSG TDEAPSLGAP DEKFEQEREG
     KALKFTYKVS RRKSKKSLFT ADEDTACDAL HTLADLSLMM PETATDTESS VQAEEKKAGE
     AYVSDFKGTD PASMSKSSSL RNSKQRRYGS NDLCNPELER KSPSSSLIQK RRQKALPAKV
     RENVLKDELA ASSQVIEPCN SKGIGEEYKP VGRGKRSASI RNSHEKKSAK SHDHTSSSNN
     IVEEDESAPS NAVIKKQVNL PTKVRSRRKI VTEKPLTIDD GKISETIEKF SHCISSFRAR
     RWCIFEWFYS AIDYPWFARQ EFVEYLDHVG LGHVPRLTRV EWGVIRSSLG KPRRFSEQFL
     KEEKEKLYLY RDSVRKHYDE LNTGMREGLP MDLARPLNVS QRVICLHPKS REIHDGNVLT
     VDHCRYRIQF DNPELGVEFV KDTECMPLNP LENMPASLAR HYAFSNYHIQ NPIEEKMHER
     AKESMLEGYP KLSCETGHLL SSPNYNISNS LKQEKVDISS SNPQAQDGVD EALALQLFNS
     QPSSIGQIQA READVQALSE LTRALDKKEL VLRELKCMND EVVESQKDGH NNALKDSESF
     KKQYAAVLFQ LSEINEQVSL ALLGLRQRNT YQENVPYSSI RRMSKSGEPD GQLTYEDNNA
     SDTNGFHVSE IVESSRIKAR KMVYRAVQAL ELLRKDENNN VNMEEAIDFV NNQLSIDQTE
     GSSVQQTQGG QDQRLPSTPN PPSSTPANDS HLNQPDQNDL QVPSDLVSRC IATLLMIQKC
     TERQFPPSEV AQVLDSAVAS LQPCCSQNLP IYTEIQKCMG IIRNQILALV PS