AM1_MAIZE
ID AM1_MAIZE Reviewed; 780 AA.
AC C0RWW9; A0A1D6GLC3;
DT 20-JUN-2018, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 1.
DT 03-AUG-2022, entry version 42.
DE RecName: Full=Protein AMEIOTIC 1 {ECO:0000303|PubMed:19204280};
GN Name=AM1 {ECO:0000303|PubMed:19204280};
GN ORFNames=ZEAMMB73_Zm00001d013659 {ECO:0000312|EMBL:AQK64115.1};
OS Zea mays (Maize).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=19204280; DOI=10.1073/pnas.0810115106;
RA Pawlowski W.P., Wang C.J., Golubovskaya I.N., Szymaniak J.M., Shi L.,
RA Hamant O., Zhu T., Harper L., Sheridan W.F., Cande W.Z.;
RT "Maize AMEIOTIC1 is essential for multiple early meiotic processes and
RT likely required for the initiation of meiosis.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:3603-3608(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. B73;
RX PubMed=19965430; DOI=10.1126/science.1178534;
RA Schnable P.S., Ware D., Fulton R.S., Stein J.C., Wei F., Pasternak S.,
RA Liang C., Zhang J., Fulton L., Graves T.A., Minx P., Reily A.D.,
RA Courtney L., Kruchowski S.S., Tomlinson C., Strong C., Delehaunty K.,
RA Fronick C., Courtney B., Rock S.M., Belter E., Du F., Kim K., Abbott R.M.,
RA Cotton M., Levy A., Marchetto P., Ochoa K., Jackson S.M., Gillam B.,
RA Chen W., Yan L., Higginbotham J., Cardenas M., Waligorski J., Applebaum E.,
RA Phelps L., Falcone J., Kanchi K., Thane T., Scimone A., Thane N., Henke J.,
RA Wang T., Ruppert J., Shah N., Rotter K., Hodges J., Ingenthron E.,
RA Cordes M., Kohlberg S., Sgro J., Delgado B., Mead K., Chinwalla A.,
RA Leonard S., Crouse K., Collura K., Kudrna D., Currie J., He R.,
RA Angelova A., Rajasekar S., Mueller T., Lomeli R., Scara G., Ko A.,
RA Delaney K., Wissotski M., Lopez G., Campos D., Braidotti M., Ashley E.,
RA Golser W., Kim H., Lee S., Lin J., Dujmic Z., Kim W., Talag J., Zuccolo A.,
RA Fan C., Sebastian A., Kramer M., Spiegel L., Nascimento L., Zutavern T.,
RA Miller B., Ambroise C., Muller S., Spooner W., Narechania A., Ren L.,
RA Wei S., Kumari S., Faga B., Levy M.J., McMahan L., Van Buren P.,
RA Vaughn M.W., Ying K., Yeh C.-T., Emrich S.J., Jia Y., Kalyanaraman A.,
RA Hsia A.-P., Barbazuk W.B., Baucom R.S., Brutnell T.P., Carpita N.C.,
RA Chaparro C., Chia J.-M., Deragon J.-M., Estill J.C., Fu Y., Jeddeloh J.A.,
RA Han Y., Lee H., Li P., Lisch D.R., Liu S., Liu Z., Nagel D.H., McCann M.C.,
RA SanMiguel P., Myers A.M., Nettleton D., Nguyen J., Penning B.W.,
RA Ponnala L., Schneider K.L., Schwartz D.C., Sharma A., Soderlund C.,
RA Springer N.M., Sun Q., Wang H., Waterman M., Westerman R., Wolfgruber T.K.,
RA Yang L., Yu Y., Zhang L., Zhou S., Zhu Q., Bennetzen J.L., Dawe R.K.,
RA Jiang J., Jiang N., Presting G.G., Wessler S.R., Aluru S.,
RA Martienssen R.A., Clifton S.W., McCombie W.R., Wing R.A., Wilson R.K.;
RT "The B73 maize genome: complexity, diversity, and dynamics.";
RL Science 326:1112-1115(2009).
CC -!- FUNCTION: Plays a fundamental role in building the proper chromosome
CC structure at the beginning of meiosis in male meiocytes. Required for
CC the transition from leptotene to zygotene in meiocytes. Required for
CC homologous chromosome pairing, and initiation and progression of
CC meiotic recombination. Regulates meiocyte cytoskeleton organization.
CC {ECO:0000269|PubMed:19204280}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19204280}. Chromosome
CC {ECO:0000269|PubMed:19204280}. Note=Diffuse localization in the nucleus
CC during the initiation of meiosis. Binds to chromatin in early meiotic
CC prophase I. {ECO:0000269|PubMed:19204280}.
CC -!- DISRUPTION PHENOTYPE: Sterile phenotype due to male meiosis arrested at
CC leptotene. {ECO:0000269|PubMed:19204280}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AQK64115.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; DQ663482; ABG57250.1; -; mRNA.
DR EMBL; CM000781; AQK64115.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; NP_001139538.1; NM_001146066.1.
DR AlphaFoldDB; C0RWW9; -.
DR SMR; C0RWW9; -.
DR STRING; 4577.GRMZM5G883855_P01; -.
DR PRIDE; C0RWW9; -.
DR GeneID; 100271891; -.
DR KEGG; zma:100271891; -.
DR eggNOG; ENOG502QU2W; Eukaryota.
DR OrthoDB; 652033at2759; -.
DR Proteomes; UP000007305; Chromosome 5.
DR ExpressionAtlas; C0RWW9; baseline and differential.
DR GO; GO:0005694; C:chromosome; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0051321; P:meiotic cell cycle; IMP:UniProtKB.
DR GO; GO:0051177; P:meiotic sister chromatid cohesion; IEA:InterPro.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IEA:InterPro.
DR InterPro; IPR044221; DYAD/AMEIOTIC1.
DR PANTHER; PTHR46740; PTHR46740; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Cell division; Chromosome; Chromosome partition; Coiled coil;
KW Meiosis; Nucleus; Reference proteome.
FT CHAIN 1..780
FT /note="Protein AMEIOTIC 1"
FT /id="PRO_0000444504"
FT REGION 32..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 237..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 448..547
FT /evidence="ECO:0000255"
FT COMPBIAS 249..264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..295
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..327
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 780 AA; 85661 MW; 3A6F406DF34DE4C2 CRC64;
MDVETVQAGP ALAAHLQLQA SPKPQVKKYY FKKKTSSSHS RNGKDDVNHD STIQPRSPLS
RQSLTFDAIP TYHAGAFYEI DHDKLPPKSP IHLKSIRVVK VSECTNLDIT VKFPSLQALR
SFFSSYPAPG TGPELDERFV MSSNHAARIL RRRVTEEELE GEVQQDSFWL IKPRLYDFAA
PQQVPSRTLC LPPPPAPPAA TLGLTADSCL LTTLKCDGAG WGMRRRVRYI GRHRDEAPKE
ASVDGYDTES SVREVQQPPA TQEVKRSERN CKRKREAEAS SKDNNGDEGK KNNKVQGASK
KISKKAKKRT VESKDGDPRH GKDRWSAERY AAAEKSLLNI MRSRDARFGA PVMRQVLREE
ARKHIGDTGL LDHLLKHMAG RVPEGSVHRF RRRHNADGAM EYWLEPAELA EVRKQAGVSD
PYWVPPPGWK PGDDVSLVAG DILVKRQVEE LTEEVNGVKR QMEQLLCKDD GDFGAERDYS
SLKEKYQRAV RANEKLEKQV LCLKDMCENV VQMNGELKKE VSAFKEKYEH IADKNDKLEE
QVTYLSSSFL SFKDQLVVAL KLELAPSEAV PRTALFVASG EQMTGTVIQG GQDRAERKSS
FRVCKPQGKF LLPSMASGMT IGRGASSTCP AAATPGPGIP RSTSFPSMPG LPRSSRGPVE
VVAAASGLDE HVMFGAHFST PPSASSTNDA AKLQLSLPSP RSPLQPQKLF DTVTAAASGF
SPQKLMHFSG LTRRDVDTSS SSSGACGSGL LEGKRVLFDA DAGGISAVGT ELALATPSYC
