ID   AMA1_PLAF8              Reviewed;         622 AA.
AC   P50492;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Apical membrane antigen 1;
DE   AltName: Full=Merozoite surface antigen;
DE   Flags: Precursor;
GN   Name=AMA-1; Synonyms=PF83;
OS   Plasmodium falciparum (isolate 7G8).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=57266;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2270110; DOI=10.1016/0166-6851(90)90172-i;
RA   Thomas A.W., Waters A.P., Carr D.;
RT   "Analysis of variation in PF83, an erythrocytic merozoite vaccine candidate
RT   antigen of Plasmodium falciparum.";
RL   Mol. Biochem. Parasitol. 42:285-287(1990).
CC   -!- FUNCTION: Involved in parasite invasion of erythrocytes.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC   -!- SIMILARITY: Belongs to the apicomplexan parasites AMA1 family.
CC       {ECO:0000305}.
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DR   EMBL; M58548; AAA29721.1; -; Genomic_DNA.
DR   AlphaFoldDB; P50492; -.
DR   BMRB; P50492; -.
DR   SMR; P50492; -.
DR   PRIDE; P50492; -.
DR   ABCD; P50492; 12 sequenced antibodies.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.1010.10; -; 1.
DR   InterPro; IPR003298; Apmem_Ag1.
DR   InterPro; IPR024056; Apmem_Ag1_dom_sf.
DR   Pfam; PF02430; AMA-1; 1.
DR   PRINTS; PR01361; MEROZOITESA.
DR   SMART; SM00815; AMA-1; 1.
DR   SUPFAM; SSF82910; SSF82910; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Glycoprotein; Malaria; Membrane; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..622
FT                   /note="Apical membrane antigen 1"
FT                   /id="PRO_0000024614"
FT   TOPO_DOM        25..546
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        547..567
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        568..622
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          577..607
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        577..606
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        162
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        286
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        371
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        421
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        422
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        499
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        149..302
FT                   /evidence="ECO:0000250"
FT   DISULFID        217..247
FT                   /evidence="ECO:0000250"
FT   DISULFID        263..275
FT                   /evidence="ECO:0000250"
FT   DISULFID        320..418
FT                   /evidence="ECO:0000250"
FT   DISULFID        337..409
FT                   /evidence="ECO:0000250"
FT   DISULFID        443..502
FT                   /evidence="ECO:0000250"
FT   DISULFID        490..507
FT                   /evidence="ECO:0000250"
FT   DISULFID        492..509
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   622 AA;  71991 MW;  1C9C8715D8E2915F CRC64;
     MRKLYCVLLL SAFEFTYMIN FGRGQNYWEH PYQKSDVYHP INEHREHSKE YEYPLHQEHT
     YQQEDSGEDE NTLQHAYPID HEGAEPAPQE QNLFSSIEIV ERSNYMGNPW TEYMAKYDIK
     EVHGSGIRVD LGEDAEVAGT QYRLPSGKCP VFGKGIIIEN SNTTFLKPVA TGNQDLKDGG
     FAFPPTNPLI SPMTLDHMRD FYKNNEYVKN LDELTLCSRH AGNMNPDNDK NSNYKYPAVY
     DYNDKKCHIL YIAAQENNGP RYCNKDESKR NSMFCFRPAK DKSFQNYTYL SKNVVDNWEK
     VCPRKNLENA KFGLWVDGNC EDIPHVNEFS ANDLFECNKL VFELSASDQP KQYEQHLTDY
     EKIKEGFKNK NASMIKSAFL PTGAFKADRY KSRGKGYNWG NYNRKTQKCE IFNVKPTCLI
     NNSSYIATTA LSHPNEVEHN FPCSLYKDEI KKEIERESKR IKLNDNDDEG NKKIIAPRIF
     ISDDIDSLKC PCDPEIVSNS TCNFFVCKCV EKRAEVTSNN EVVVKEEYKD EYADIPEHKP
     TYDKMKIIIA SSAAVAVLAT ILMVYLYKRK GNAEKYDKMD EPQDYGKSNS RNDEMLDPEA
     SFWGEEKRAS HTTPVLMEKP YY