AMA1_PLAFC
ID AMA1_PLAFC Reviewed; 622 AA.
AC P50489;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Apical membrane antigen 1;
DE AltName: Full=Merozoite surface antigen;
DE Flags: Precursor;
GN Name=AMA-1; Synonyms=PF83;
OS Plasmodium falciparum (isolate Camp / Malaysia).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5835;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2270110; DOI=10.1016/0166-6851(90)90172-i;
RA Thomas A.W., Waters A.P., Carr D.;
RT "Analysis of variation in PF83, an erythrocytic merozoite vaccine candidate
RT antigen of Plasmodium falciparum.";
RL Mol. Biochem. Parasitol. 42:285-287(1990).
CC -!- FUNCTION: Involved in parasite invasion of erythrocytes.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC -!- SIMILARITY: Belongs to the apicomplexan parasites AMA1 family.
CC {ECO:0000305}.
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DR EMBL; M58545; AAA29718.1; -; Genomic_DNA.
DR PDB; 3SRI; X-ray; 1.60 A; A=97-442.
DR PDBsum; 3SRI; -.
DR AlphaFoldDB; P50489; -.
DR BMRB; P50489; -.
DR SMR; P50489; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 4.10.1010.10; -; 1.
DR InterPro; IPR003298; Apmem_Ag1.
DR InterPro; IPR024056; Apmem_Ag1_dom_sf.
DR Pfam; PF02430; AMA-1; 1.
DR PRINTS; PR01361; MEROZOITESA.
DR SMART; SM00815; AMA-1; 1.
DR SUPFAM; SSF82910; SSF82910; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Disulfide bond; Glycoprotein; Malaria; Membrane; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..622
FT /note="Apical membrane antigen 1"
FT /id="PRO_0000024610"
FT TOPO_DOM 25..546
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 547..567
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 568..622
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 577..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..606
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 162
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 286
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 371
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 421
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 422
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 499
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 149..302
FT /evidence="ECO:0000250"
FT DISULFID 217..247
FT /evidence="ECO:0000250"
FT DISULFID 263..275
FT /evidence="ECO:0000250"
FT DISULFID 320..418
FT /evidence="ECO:0000250"
FT DISULFID 337..409
FT /evidence="ECO:0000250"
FT DISULFID 443..502
FT /evidence="ECO:0000250"
FT DISULFID 490..507
FT /evidence="ECO:0000250"
FT DISULFID 492..509
FT /evidence="ECO:0000250"
FT HELIX 111..114
FT /evidence="ECO:0007829|PDB:3SRI"
FT HELIX 115..117
FT /evidence="ECO:0007829|PDB:3SRI"
FT HELIX 119..122
FT /evidence="ECO:0007829|PDB:3SRI"
FT STRAND 127..129
FT /evidence="ECO:0007829|PDB:3SRI"
FT STRAND 133..137
FT /evidence="ECO:0007829|PDB:3SRI"
FT STRAND 140..144
FT /evidence="ECO:0007829|PDB:3SRI"
FT STRAND 154..158
FT /evidence="ECO:0007829|PDB:3SRI"
FT STRAND 161..164
FT /evidence="ECO:0007829|PDB:3SRI"
FT STRAND 172..174
FT /evidence="ECO:0007829|PDB:3SRI"
FT HELIX 176..178
FT /evidence="ECO:0007829|PDB:3SRI"
FT STRAND 186..188
FT /evidence="ECO:0007829|PDB:3SRI"
FT STRAND 191..194
FT /evidence="ECO:0007829|PDB:3SRI"
FT HELIX 195..201
FT /evidence="ECO:0007829|PDB:3SRI"
FT TURN 202..204
FT /evidence="ECO:0007829|PDB:3SRI"
FT TURN 206..210
FT /evidence="ECO:0007829|PDB:3SRI"
FT HELIX 213..222
FT /evidence="ECO:0007829|PDB:3SRI"
FT STRAND 227..229
FT /evidence="ECO:0007829|PDB:3SRI"
FT STRAND 238..241
FT /evidence="ECO:0007829|PDB:3SRI"
FT TURN 242..245
FT /evidence="ECO:0007829|PDB:3SRI"
FT STRAND 246..251
FT /evidence="ECO:0007829|PDB:3SRI"
FT STRAND 276..280
FT /evidence="ECO:0007829|PDB:3SRI"
FT HELIX 282..284
FT /evidence="ECO:0007829|PDB:3SRI"
FT STRAND 287..290
FT /evidence="ECO:0007829|PDB:3SRI"
FT HELIX 298..301
FT /evidence="ECO:0007829|PDB:3SRI"
FT STRAND 305..316
FT /evidence="ECO:0007829|PDB:3SRI"
FT STRAND 319..322
FT /evidence="ECO:0007829|PDB:3SRI"
FT STRAND 327..330
FT /evidence="ECO:0007829|PDB:3SRI"
FT HELIX 334..344
FT /evidence="ECO:0007829|PDB:3SRI"
FT STRAND 399..403
FT /evidence="ECO:0007829|PDB:3SRI"
FT TURN 404..407
FT /evidence="ECO:0007829|PDB:3SRI"
FT STRAND 408..414
FT /evidence="ECO:0007829|PDB:3SRI"
FT STRAND 418..429
FT /evidence="ECO:0007829|PDB:3SRI"
SQ SEQUENCE 622 AA; 71944 MW; 26CE8CF76D07C637 CRC64;
MRKLYCVLLL SAFEFTYMIN FGRGQNYWEH PYQNSNVYHP INEHREHPKE YQYPLHQEHT
YQQEDSGEDE NTLQHAYPID HEGAEPAPQE QNLFSSIEIV ERSNYMGNPW TEYMAKYDIE
EVHGSGIRVD LGEDAEVAGT QYRLPSGKCP VFGKGIIIEN SNTTFLKPVA TGNQDLKDGG
FAFPPTEPLI SPMTLNGMRD FYKNNEYVKN LDELTLCSRH AGNMNPDKDE NSNYKYPAVY
DDKDKKCHIL YIAAQENNGP RYCNKDESKR NSMFCFRPAK DKSFQNYTYL SKNVVDNWEK
VCPRKNLENA KFGLWVDGNC EDIPHVNEFS ANDLFECNKL VFELSASDQP KQYEQHLTDY
EKIKEGFKNK NASMIKSAFL PTGAFKADRY KSHGKGYNWG NYNRKTHKCE IFNVKPTCLI
NNSSYIATTA LSHPIEVENN FPCSLYKNEI MKEIERESKR IKLNDNDDEG NKKIIAPRIF
ISDDKDSLKC PCDPEMVSNS TCRFFVCKCV ERRAEVTSNN EVVVKEEYKD EYADIPEHKP
TYDNMKIIIA SSAAVAVLAT ILMVYLYKRK GNAEKYDKMD QPQDYGKSTS RNDEMLDPEA
SFWGEEKRAS HTTPVLMEKP YY
