ID   104K_THEAN              Reviewed;         893 AA.
AC   Q4U9M9;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=104 kDa microneme/rhoptry antigen;
DE   AltName: Full=p104;
DE   Flags: Precursor;
GN   ORFNames=TA08425;
OS   Theileria annulata.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC   Theileriidae; Theileria.
OX   NCBI_TaxID=5874;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ankara;
RX   PubMed=15994557; DOI=10.1126/science.1110418;
RA   Pain A., Renauld H., Berriman M., Murphy L., Yeats C.A., Weir W.,
RA   Kerhornou A., Aslett M., Bishop R., Bouchier C., Cochet M., Coulson R.M.R.,
RA   Cronin A., de Villiers E.P., Fraser A., Fosker N., Gardner M., Goble A.,
RA   Griffiths-Jones S., Harris D.E., Katzer F., Larke N., Lord A., Maser P.,
RA   McKellar S., Mooney P., Morton F., Nene V., O'Neil S., Price C.,
RA   Quail M.A., Rabbinowitsch E., Rawlings N.D., Rutter S., Saunders D.,
RA   Seeger K., Shah T., Squares R., Squares S., Tivey A., Walker A.R.,
RA   Woodward J., Dobbelaere D.A.E., Langsley G., Rajandream M.A., McKeever D.,
RA   Shiels B., Tait A., Barrell B.G., Hall N.;
RT   "Genome of the host-cell transforming parasite Theileria annulata compared
RT   with T. parva.";
RL   Science 309:131-133(2005).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC       anchor {ECO:0000305}. Note=In microneme/rhoptry complexes.
CC       {ECO:0000250}.
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DR   EMBL; CR940353; CAI76474.1; -; Genomic_DNA.
DR   RefSeq; XP_953099.1; XM_948006.1.
DR   AlphaFoldDB; Q4U9M9; -.
DR   GeneID; 3863060; -.
DR   KEGG; tan:TA08425; -.
DR   VEuPathDB; PiroplasmaDB:TA08425; -.
DR   eggNOG; ENOG502RY34; Eukaryota.
DR   InParanoid; Q4U9M9; -.
DR   OMA; NGHICKM; -.
DR   OrthoDB; 1492494at2759; -.
DR   Proteomes; UP000001950; Chromosome 4.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Reference proteome; Repeat; Signal; Sporozoite.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..873
FT                   /note="104 kDa microneme/rhoptry antigen"
FT                   /id="PRO_0000232680"
FT   PROPEP          874..893
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000232681"
FT   REGION          492..666
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          681..799
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          818..873
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        494..510
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        524..592
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        611..628
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        629..660
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        729..756
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        818..848
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        849..866
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           873
FT                   /note="GPI-anchor amidated aspartate"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   893 AA;  101921 MW;  2F67CEB3B02E7AC1 CRC64;
     MKFLVLLFNI LCLFPILGAD ELVMSPIPTT DVQPKVTFDI NSEVSSGPLY LNPVEMAGVK
     YLQLQRQPGV QVHKVVEGDI VIWENEEMPL YTCAIVTQNE VPYMAYVELL EDPDLIFFLK
     EGDQWAPIPE DQYLARLQQL RQQIHTESFF SLNLSFQHEN YKYEMVSSFQ HSIKMVVFTP
     KNGHICKMVY DKNIRIFKAL YNEYVTSVIG FFRGLKLLLL NIFVIDDRGM IGNKYFQLLD
     DKYAPISVQG YVATIPKLKD FAEPYHPIIL DISDIDYVNF YLGDATYHDP GFKIVPKTPQ
     CITKVVDGNE VIYESSNPSV ECVYKVTYYD KKNESMLRLD LNHSPPSYTS YYAKREGVWV
     TSTYIDLEEK IEELQDHRST ELDVMFMSDK DLNVVPLTNG NLEYFMVTPK PHRDIIIVFD
     GSEVLWYYEG LENHLVCTWI YVTEGAPRLV HLRVKDRIPQ NTDIYMVKFG EYWVRISKTQ
     YTQEIKKLIK KSKKKLPSIE EEDSDKHGGP PKGPEPPTGP GHSSSESKEH EDSKESKEPK
     EHGSPKETKE GEVTKKPGPA KEHKPSKIPV YTKRPEFPKK SKSPKRPESP KSPKRPVSPQ
     RPVSPKSPKR PESLDIPKSP KRPESPKSPK RPVSPQRPVS PRRPESPKSP KSPKSPKSPK
     VPFDPKFKEK LYDSYLDKAA KTKETVTLPP VLPTDESFTH TPIGEPTAEQ PDDIEPIEES
     VFIKETGILT EEVKTEDIHS ETGEPEEPKR PDSPTKHSPK PTGTHPSMPK KRRRSDGLAL
     STTDLESEAG RILRDPTGKI VTMKRSKSFD DLTTVREKEH MGAEIRKIVV DDDGTEADDE
     DTHPSKEKHL STVRRRRPRP KKSSKSSKPR KPDSAFVPSI IFIFLVSLIV GIL