GLNP_ECOLI
ID GLNP_ECOLI Reviewed; 219 AA.
AC P0AEQ6; P10345; P76825;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Glutamine transport system permease protein GlnP;
GN Name=glnP; OrderedLocusNames=b0810, JW0795;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=3027504; DOI=10.1007/bf00430437;
RA Nohno T., Saito T., Hong J.;
RT "Cloning and complete nucleotide sequence of the Escherichia coli glutamine
RT permease operon (glnHPQ).";
RL Mol. Gen. Genet. 205:260-269(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K.,
RA Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S.,
RA Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K., Mori H.,
RA Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G.,
RA Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M.,
RA Horiuchi T.;
RT "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 12.7-28.0 min region on the linkage map.";
RL DNA Res. 3:137-155(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- FUNCTION: Part of the binding-protein-dependent transport system for
CC glutamine; probably responsible for the translocation of the substrate
CC across the membrane.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- INDUCTION: By lack of glutamine.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. HisMQ subfamily. {ECO:0000305}.
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DR EMBL; X14180; CAA32383.1; -; Genomic_DNA.
DR EMBL; U00096; AAC73897.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA35482.1; -; Genomic_DNA.
DR PIR; S03182; QRECGP.
DR RefSeq; NP_415331.1; NC_000913.3.
DR RefSeq; WP_001159065.1; NZ_STEB01000019.1.
DR AlphaFoldDB; P0AEQ6; -.
DR SMR; P0AEQ6; -.
DR BioGRID; 4259971; 24.
DR ComplexPortal; CPX-4822; Glutamine ABC transporter complex.
DR DIP; DIP-47993N; -.
DR STRING; 511145.b0810; -.
DR TCDB; 3.A.1.3.2; the atp-binding cassette (abc) superfamily.
DR jPOST; P0AEQ6; -.
DR PaxDb; P0AEQ6; -.
DR PRIDE; P0AEQ6; -.
DR EnsemblBacteria; AAC73897; AAC73897; b0810.
DR EnsemblBacteria; BAA35482; BAA35482; BAA35482.
DR GeneID; 66670918; -.
DR GeneID; 945621; -.
DR KEGG; ecj:JW0795; -.
DR KEGG; eco:b0810; -.
DR PATRIC; fig|1411691.4.peg.1468; -.
DR EchoBASE; EB0383; -.
DR eggNOG; COG0765; Bacteria.
DR HOGENOM; CLU_019602_1_0_6; -.
DR InParanoid; P0AEQ6; -.
DR OMA; IGLHYST; -.
DR PhylomeDB; P0AEQ6; -.
DR BioCyc; EcoCyc:GLNP-MON; -.
DR BioCyc; MetaCyc:GLNP-MON; -.
DR PRO; PR:P0AEQ6; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0055052; C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; IC:ComplexPortal.
DR GO; GO:0016020; C:membrane; IC:ComplexPortal.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006865; P:amino acid transport; IBA:GO_Central.
DR GO; GO:1903803; P:L-glutamine import across plasma membrane; IC:ComplexPortal.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; -; 1.
DR InterPro; IPR010065; AA_ABC_transptr_permease_3TM.
DR InterPro; IPR043429; ArtM/GltK/GlnP/TcyL/YhdX-like.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR PANTHER; PTHR30614; PTHR30614; 1.
DR Pfam; PF00528; BPD_transp_1; 1.
DR SUPFAM; SSF161098; SSF161098; 1.
DR TIGRFAMs; TIGR01726; HEQRo_perm_3TM; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 1: Evidence at protein level;
KW Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..219
FT /note="Glutamine transport system permease protein GlnP"
FT /id="PRO_0000060030"
FT TOPO_DOM 1..22
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 44..53
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 75..88
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 110..150
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 172..187
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 209..219
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 19..209
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ SEQUENCE 219 AA; 24364 MW; 20A94A31BE02121C CRC64;
MQFDWSAIWP AIPLLIEGAK MTLWISVLGL AGGLVIGLLA GFARTFGGWI ANHVALVFIE
VIRGTPIVVQ VMFIYFALPM AFNDLRIDPF TAAVVTIMIN SGAYIAEITR GAVLSIHKGF
REAGLALGLS RWETIRYVIL PLALRRMLPP LGNQWIISIK DTSLFIVIGV AELTRQGQEI
IAGNFRALEI WSAVAVFYLI ITLVLSFILR RLERRMKIL
