GLNQ_ECOLI
ID GLNQ_ECOLI Reviewed; 240 AA.
AC P10346;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 1.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Glutamine transport ATP-binding protein GlnQ;
GN Name=glnQ; OrderedLocusNames=b0809, JW0794;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=3027504; DOI=10.1007/bf00430437;
RA Nohno T., Saito T., Hong J.;
RT "Cloning and complete nucleotide sequence of the Escherichia coli glutamine
RT permease operon (glnHPQ).";
RL Mol. Gen. Genet. 205:260-269(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K.,
RA Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S.,
RA Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K., Mori H.,
RA Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G.,
RA Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M.,
RA Horiuchi T.;
RT "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 12.7-28.0 min region on the linkage map.";
RL DNA Res. 3:137-155(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP IDENTIFICATION BY 2D-GEL.
RX PubMed=9298644; DOI=10.1002/elps.1150180805;
RA VanBogelen R.A., Abshire K.Z., Moldover B., Olson E.R., Neidhardt F.C.;
RT "Escherichia coli proteome analysis using the gene-protein database.";
RL Electrophoresis 18:1243-1251(1997).
RN [6]
RP SUBUNIT, AND SUBCELLULAR LOCATION.
RC STRAIN=BL21-DE3;
RX PubMed=16079137; DOI=10.1074/jbc.m506479200;
RA Stenberg F., Chovanec P., Maslen S.L., Robinson C.V., Ilag L.,
RA von Heijne G., Daley D.O.;
RT "Protein complexes of the Escherichia coli cell envelope.";
RL J. Biol. Chem. 280:34409-34419(2005).
CC -!- FUNCTION: Part of the binding-protein-dependent transport system for
CC glutamine. Probably responsible for energy coupling to the transport
CC system.
CC -!- SUBUNIT: Heterotetramer with 2 subunits of GlnQ and 2 subunits of GlnP.
CC {ECO:0000269|PubMed:16079137}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000269|PubMed:16079137}; Peripheral membrane protein
CC {ECO:0000269|PubMed:16079137}.
CC -!- INDUCTION: By lack of glutamine.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR EMBL; X14180; CAA32384.1; -; Genomic_DNA.
DR EMBL; U00096; AAC73896.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA35481.1; -; Genomic_DNA.
DR PIR; S03183; QRECGQ.
DR RefSeq; NP_415330.1; NC_000913.3.
DR RefSeq; WP_000569083.1; NZ_STEB01000019.1.
DR AlphaFoldDB; P10346; -.
DR SMR; P10346; -.
DR BioGRID; 4259970; 13.
DR BioGRID; 849809; 2.
DR ComplexPortal; CPX-4822; Glutamine ABC transporter complex.
DR DIP; DIP-9786N; -.
DR IntAct; P10346; 2.
DR STRING; 511145.b0809; -.
DR TCDB; 3.A.1.3.2; the atp-binding cassette (abc) superfamily.
DR jPOST; P10346; -.
DR PaxDb; P10346; -.
DR PRIDE; P10346; -.
DR EnsemblBacteria; AAC73896; AAC73896; b0809.
DR EnsemblBacteria; BAA35481; BAA35481; BAA35481.
DR GeneID; 58463804; -.
DR GeneID; 945435; -.
DR KEGG; ecj:JW0794; -.
DR KEGG; eco:b0809; -.
DR PATRIC; fig|1411691.4.peg.1469; -.
DR EchoBASE; EB0384; -.
DR eggNOG; COG1126; Bacteria.
DR HOGENOM; CLU_000604_1_22_6; -.
DR InParanoid; P10346; -.
DR OMA; EFIYIIG; -.
DR PhylomeDB; P10346; -.
DR BioCyc; EcoCyc:GLNQ-MON; -.
DR BioCyc; MetaCyc:GLNQ-MON; -.
DR PRO; PR:P10346; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0055052; C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; IC:ComplexPortal.
DR GO; GO:0016020; C:membrane; IC:ComplexPortal.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0015424; F:ABC-type amino acid transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; ISM:EcoCyc.
DR GO; GO:1903803; P:L-glutamine import across plasma membrane; IC:ComplexPortal.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR030679; ABC_ATPase_HisP-typ.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 1.
DR PIRSF; PIRSF039085; ABC_ATPase_HisP; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 1: Evidence at protein level;
KW Amino-acid transport; ATP-binding; Cell inner membrane; Cell membrane;
KW Membrane; Nucleotide-binding; Reference proteome; Transport.
FT CHAIN 1..240
FT /note="Glutamine transport ATP-binding protein GlnQ"
FT /id="PRO_0000092334"
FT DOMAIN 2..236
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 34..41
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 240 AA; 26731 MW; BA931A5ADF42DB30 CRC64;
MIEFKNVSKH FGPTQVLHNI DLNIAQGEVV VIIGPSGSGK STLLRCINKL EEITSGDLIV
DGLKVNDPKV DERLIRQEAG MVFQQFYLFP HLTALENVMF GPLRVRGANK EEAEKLAREL
LAKVGLAERA HHYPSELSGG QQQRVAIARA LAVKPKMMLF DEPTSALDPE LRHEVLKVMQ
DLAEEGMTMV IVTHEIGFAE KVASRLIFID KGRIAEDGNP QVLIKNPPSQ RLQEFLQHVS
