ID   GLNR_STRCO              Reviewed;         267 AA.
AC   Q05943;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   25-MAY-2022, entry version 119.
DE   RecName: Full=Transcriptional regulatory protein GlnR;
GN   Name=glnR; OrderedLocusNames=SCO4159; ORFNames=SCD84.26c;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A3(2) / NRRL B-16638;
RX   PubMed=7688332; DOI=10.1016/0378-1119(93)90359-b;
RA   Wray L.V. Jr., Fisher S.H.;
RT   "The Streptomyces coelicolor glnR gene encodes a protein similar to other
RT   bacterial response regulators.";
RL   Gene 130:145-150(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: Activates the transcription of the glnA gene.
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DR   EMBL; L03213; AAA02838.1; -; Unassigned_DNA.
DR   EMBL; AL939119; CAB88492.1; -; Genomic_DNA.
DR   PIR; JN0831; JN0831.
DR   RefSeq; NP_628336.1; NC_003888.3.
DR   RefSeq; WP_011029474.1; NZ_VNID01000038.1.
DR   AlphaFoldDB; Q05943; -.
DR   SMR; Q05943; -.
DR   STRING; 100226.SCO4159; -.
DR   GeneID; 1099599; -.
DR   KEGG; sco:SCO4159; -.
DR   PATRIC; fig|100226.15.peg.4223; -.
DR   eggNOG; COG0745; Bacteria.
DR   HOGENOM; CLU_000445_30_4_11; -.
DR   InParanoid; Q05943; -.
DR   OMA; SPMEIRN; -.
DR   PhylomeDB; Q05943; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0032993; C:protein-DNA complex; IBA:GO_Central.
DR   GO; GO:0001216; F:DNA-binding transcription activator activity; IBA:GO_Central.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..267
FT                   /note="Transcriptional regulatory protein GlnR"
FT                   /id="PRO_0000081105"
FT   DNA_BIND        124..221
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   REGION          220..267
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        220..251
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         50
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   267 AA;  28887 MW;  54069CDB07C1BFB1 CRC64;
     MSSLLLLTNA LQPSTEVLPA LGLLLHNVRV APAEGPALVD TPGADVILVD GRRDLPQIRS
     LCQLLRSTGL SCPLVLIVTE GGLAAVTADW GIDDVLLDTA GPAEVEARLR LATGRQQLGG
     DDSPMEIRNG DLSVDEATYS AKLKGRVLDL TFKEFELLKY LAQHPGRVFT RAQLLQEVWG
     YDYFGGTRTV DVHVRRLRAK LGPEHESLIG TVRNVGYRFV TPEKPEKGEK SDKSEKAERA
     EKAERAETPG KAAAETNEAA GARSSKV