ID   AMBN_MOUSE              Reviewed;         407 AA.
AC   O55189;
DT   10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Ameloblastin;
DE   Flags: Precursor;
GN   Name=Ambn;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Swiss Webster; TISSUE=Molar;
RX   PubMed=11062984; DOI=10.3109/03008209809023907;
RA   Simmons D., Gu T.T., Krebsbach P.H., Yamada Y., MacDougall M.;
RT   "Identification and characterization of a cDNA for mouse ameloblastin.";
RL   Connect. Tissue Res. 39:3-12(1998).
CC   -!- FUNCTION: Involved in the mineralization and structural organization of
CC       enamel.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix.
CC   -!- TISSUE SPECIFICITY: Ameloblast-specific.
CC   -!- SIMILARITY: Belongs to the ameloblastin family. {ECO:0000305}.
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DR   EMBL; U65021; AAB93765.1; -; mRNA.
DR   CCDS; CCDS51539.1; -.
DR   RefSeq; NP_033794.1; NM_009664.2.
DR   AlphaFoldDB; O55189; -.
DR   STRING; 10090.ENSMUSP00000031226; -.
DR   PhosphoSitePlus; O55189; -.
DR   PaxDb; O55189; -.
DR   PRIDE; O55189; -.
DR   Antibodypedia; 24340; 130 antibodies from 21 providers.
DR   DNASU; 11698; -.
DR   Ensembl; ENSMUST00000031226; ENSMUSP00000031226; ENSMUSG00000029288.
DR   GeneID; 11698; -.
DR   KEGG; mmu:11698; -.
DR   UCSC; uc008xzr.2; mouse.
DR   CTD; 258; -.
DR   MGI; MGI:104655; Ambn.
DR   VEuPathDB; HostDB:ENSMUSG00000029288; -.
DR   eggNOG; ENOG502QWCP; Eukaryota.
DR   GeneTree; ENSGT00390000018227; -.
DR   InParanoid; O55189; -.
DR   TreeFam; TF337860; -.
DR   Reactome; R-MMU-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
DR   Reactome; R-MMU-8957275; Post-translational protein phosphorylation.
DR   BioGRID-ORCS; 11698; 3 hits in 58 CRISPR screens.
DR   PRO; PR:O55189; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; O55189; protein.
DR   Bgee; ENSMUSG00000029288; Expressed in molar tooth and 31 other tissues.
DR   ExpressionAtlas; O55189; baseline and differential.
DR   Genevisible; O55189; MM.
DR   GO; GO:0031012; C:extracellular matrix; TAS:MGI.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0030021; F:extracellular matrix structural constituent conferring compression resistance; TAS:MGI.
DR   GO; GO:0008083; F:growth factor activity; IMP:BHF-UCL.
DR   GO; GO:0030345; F:structural constituent of tooth enamel; IEA:InterPro.
DR   GO; GO:0031214; P:biomineral tissue development; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IMP:BHF-UCL.
DR   GO; GO:0030198; P:extracellular matrix organization; TAS:MGI.
DR   GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:InterPro.
DR   GO; GO:0042127; P:regulation of cell population proliferation; IMP:BHF-UCL.
DR   InterPro; IPR007798; Amelin.
DR   PANTHER; PTHR14115; PTHR14115; 1.
DR   Pfam; PF05111; Amelin; 1.
DR   SMART; SM00817; Amelin; 1.
PE   2: Evidence at transcript level;
KW   Biomineralization; Extracellular matrix; Hydroxylation; Phosphoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..407
FT                   /note="Ameloblastin"
FT                   /id="PRO_0000001193"
FT   REGION          124..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          259..304
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         42
FT                   /note="Hydroxyproline"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         48
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q28989"
SQ   SEQUENCE   407 AA;  43664 MW;  D702E991824205DA CRC64;
     MSASKIPLFK MKGLILFLSL VKMSLAVPAF PQQPGAQGMA PPGMASLSLE TMRQLGSLQG
     LNALSQYSRL GFGKALNSLW LHGLLPPHNS FPWIGPREHE TQQPSLQPHQ PGLKPFLQPT
     AATGVQVTPQ KPGPQPPMHP GQLPLQEGEL IAPDEPQVAP SENPPTPEVP IMDFADPQFP
     TVFQIARSIS RGPMAHNKAS AFYPGMFYMS YGANQLNAPA RIGFMSSEEM PGERGSPMAY
     GTLFPRFGGF RQTLRRLNQN SPKGGDFTVE VDSPVSVTKG PEKGEGPEGS PLQEANPGKR
     ENPALLSQMA PGAHAGLLAF PNDHIPSMAR GPAGQRLLGV TPAAADPLIT PELAEVYETY
     GADVTTPLGD GEATMDITMS PDTQQPLLPG NKVHQPQVHN AWRFQEP