ID   AMC_RABIT               Reviewed;          76 AA.
AC   P82535;
DT   04-MAY-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Alveolar macrophage chemotactic factor;
DE   AltName: Full=Neutrophil chemotactic protein;
DE            Short=NPC;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AND MASS SPECTROMETRY.
RC   TISSUE=Alveolar macrophage;
RX   PubMed=11087410; DOI=10.1021/bi0011227;
RA   Wuyts A., Schutyser E., Menten P., Struyf S., D'Haese A., Bult H.,
RA   Opdenakker G., Proost P., Van Damme J.;
RT   "Biochemical and biological characterization of neutrophil chemotactic
RT   protein, a novel rabbit CXC chemokine from alveolar macrophages.";
RL   Biochemistry 39:14549-14557(2000).
CC   -!- FUNCTION: Has chemotactic activity for neutrophils.
CC       {ECO:0000269|PubMed:11087410}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Alveolar macrophages.
CC   -!- MASS SPECTROMETRY: Mass=8086.0; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:11087410};
CC   -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P82535; -.
DR   SMR; P82535; -.
DR   STRING; 9986.ENSOCUP00000010175; -.
DR   eggNOG; ENOG502S7MM; Eukaryota.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0008009; F:chemokine activity; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; IDA:UniProtKB.
DR   GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IDA:UniProtKB.
DR   CDD; cd00273; Chemokine_CXC; 1.
DR   InterPro; IPR001089; Chemokine_CXC.
DR   InterPro; IPR018048; Chemokine_CXC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR033899; CXC_Chemokine_domain.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR10179; PTHR10179; 1.
DR   Pfam; PF00048; IL8; 1.
DR   PRINTS; PR00437; SMALLCYTKCXC.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
PE   1: Evidence at protein level;
KW   Chemotaxis; Cytokine; Direct protein sequencing; Disulfide bond;
KW   Inflammatory response; Reference proteome; Secreted.
FT   CHAIN           1..76
FT                   /note="Alveolar macrophage chemotactic factor"
FT                   /id="PRO_0000144302"
FT   DISULFID        12..37
FT   DISULFID        14..53
FT   VARIANT         1..7
FT                   /note="Missing (in N-terminal processing variant)"
FT   VARIANT         1..6
FT                   /note="Missing (in N-terminal processing variant)"
FT   VARIANT         1..5
FT                   /note="Missing (in N-terminal processing variant)"
FT   VARIANT         1..4
FT                   /note="Missing (in N-terminal processing variant)"
SQ   SEQUENCE   76 AA;  8091 MW;  C85EA928EE2D64B3 CRC64;
     GPVAAVVREL RCVCLSTTAI HPKMIARLQV IAAGPQCSKV EVVASLKNGK EICLDPEAPL
     IKKAIQKILE SGNKEN