ID   AMDA_BORBO              Reviewed;         240 AA.
AC   Q05115;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Arylmalonate decarboxylase;
DE            Short=AMDase;
DE            EC=4.1.1.76;
OS   Bordetella bronchiseptica (Alcaligenes bronchisepticus).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=518;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 1-10.
RC   STRAIN=KU 1201;
RX   PubMed=1369144; DOI=10.1007/bf00174474;
RA   Miyamoto K., Ohta H.;
RT   "Cloning and heterologous expression of a novel arylmalonate decarboxylase
RT   gene from Alcaligenes bronchisepticus KU 1201.";
RL   Appl. Microbiol. Biotechnol. 38:234-238(1992).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-aryl-2-methylmalonate + H(+) = 2-arylpropionate + CO2;
CC         Xref=Rhea:RHEA:20513, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:57542, ChEBI:CHEBI:57738; EC=4.1.1.76;
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; S54007; AAC60426.1; -; Genomic_DNA.
DR   EMBL; D13116; BAA02419.1; -; Genomic_DNA.
DR   PIR; A48374; JS0754.
DR   PDB; 2VLB; X-ray; 1.92 A; A/B/C/D=1-240.
DR   PDB; 3DG9; X-ray; 1.50 A; A=1-240.
DR   PDB; 3DTV; X-ray; 2.10 A; A/B/C/D=1-240.
DR   PDB; 3EIS; X-ray; 2.10 A; A/B/C/D=1-240.
DR   PDB; 3IP8; X-ray; 1.50 A; A=1-240.
DR   PDB; 3IXL; X-ray; 1.45 A; A=1-240.
DR   PDB; 3IXM; X-ray; 1.90 A; A=1-240.
DR   PDBsum; 2VLB; -.
DR   PDBsum; 3DG9; -.
DR   PDBsum; 3DTV; -.
DR   PDBsum; 3EIS; -.
DR   PDBsum; 3IP8; -.
DR   PDBsum; 3IXL; -.
DR   PDBsum; 3IXM; -.
DR   AlphaFoldDB; Q05115; -.
DR   SMR; Q05115; -.
DR   KEGG; ag:AAC60426; -.
DR   BRENDA; 4.1.1.76; 227.
DR   EvolutionaryTrace; Q05115; -.
DR   GO; GO:0047436; F:arylmalonate decarboxylase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR026286; MaiA/AMDase.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   PANTHER; PTHR40267; PTHR40267; 1.
DR   Pfam; PF17645; Amdase; 1.
DR   PIRSF; PIRSF015736; MI; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Decarboxylase; Direct protein sequencing; Lyase.
FT   CHAIN           1..240
FT                   /note="Arylmalonate decarboxylase"
FT                   /id="PRO_0000064576"
FT   STRAND          8..15
FT                   /evidence="ECO:0007829|PDB:3IXL"
FT   HELIX           23..27
FT                   /evidence="ECO:0007829|PDB:3IXL"
FT   STRAND          33..37
FT                   /evidence="ECO:0007829|PDB:3IXL"
FT   HELIX           39..41
FT                   /evidence="ECO:0007829|PDB:3DTV"
FT   HELIX           45..51
FT                   /evidence="ECO:0007829|PDB:3IXL"
FT   HELIX           52..54
FT                   /evidence="ECO:0007829|PDB:3IXL"
FT   HELIX           55..64
FT                   /evidence="ECO:0007829|PDB:3IXL"
FT   STRAND          67..72
FT                   /evidence="ECO:0007829|PDB:3IXL"
FT   HELIX           75..79
FT                   /evidence="ECO:0007829|PDB:3IXL"
FT   HELIX           83..97
FT                   /evidence="ECO:0007829|PDB:3IXL"
FT   STRAND          101..103
FT                   /evidence="ECO:0007829|PDB:3IXL"
FT   HELIX           104..114
FT                   /evidence="ECO:0007829|PDB:3IXL"
FT   STRAND          118..126
FT                   /evidence="ECO:0007829|PDB:3IXL"
FT   HELIX           128..140
FT                   /evidence="ECO:0007829|PDB:3IXL"
FT   STRAND          144..150
FT                   /evidence="ECO:0007829|PDB:3IXL"
FT   HELIX           156..160
FT                   /evidence="ECO:0007829|PDB:3IXL"
FT   HELIX           164..176
FT                   /evidence="ECO:0007829|PDB:3IXL"
FT   STRAND          182..187
FT                   /evidence="ECO:0007829|PDB:3IXL"
FT   STRAND          189..191
FT                   /evidence="ECO:0007829|PDB:3DTV"
FT   HELIX           196..204
FT                   /evidence="ECO:0007829|PDB:3IXL"
FT   STRAND          208..210
FT                   /evidence="ECO:0007829|PDB:3IXL"
FT   HELIX           211..222
FT                   /evidence="ECO:0007829|PDB:3IXL"
FT   STRAND          231..233
FT                   /evidence="ECO:0007829|PDB:3IXL"
FT   HELIX           235..238
FT                   /evidence="ECO:0007829|PDB:3IXL"
SQ   SEQUENCE   240 AA;  24735 MW;  2514373725BDAA7F CRC64;
     MQQASTPTIG MIVPPAAGLV PADGARLYPD LPFIASGLGL GSVTPEGYDA VIESVVDHAR
     RLQKQGAAVV SLMGTSLSFY RGAAFNAALT VAMREATGLP CTTMSTAVLN GLRALGVRRV
     ALATAYIDDV NERLAAFLAE ESLVPTGCRS LGITGVEAMA RVDTATLVDL CVRAFEAAPD
     SDGILLSCGG LLTLDAIPEV ERRLGVPVVS SSPAGFWDAV RLAGGGAKAR PGYGRLFDES