ID   GLOD4_CAEBR             Reviewed;         281 AA.
AC   A8XX92;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Glyoxalase 1;
DE   AltName: Full=Glyoxalase domain-containing protein 4 {ECO:0000250|UniProtKB:Q09253};
GN   Name=glod-4 {ECO:0000312|EMBL:CAP37261.1}; ORFNames=CBG20174;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1] {ECO:0000312|EMBL:CAP37261.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000312|EMBL:CAP37261.1};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Thought to act as a glyoxalase. May remove methylglyoxal from
CC       mitochondrial proteins. Has roles in reducing oxidative stress and
CC       increasing lifespan (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the glyoxalase I family. {ECO:0000255}.
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DR   EMBL; HE601013; CAP37261.1; -; Genomic_DNA.
DR   RefSeq; XP_002642548.1; XM_002642502.1.
DR   AlphaFoldDB; A8XX92; -.
DR   SMR; A8XX92; -.
DR   STRING; 6238.CBG20174; -.
DR   EnsemblMetazoa; CBG20174.1; CBG20174.1; WBGene00039226.
DR   GeneID; 8584542; -.
DR   KEGG; cbr:CBG_20174; -.
DR   CTD; 8584542; -.
DR   WormBase; CBG20174; CBP11431; WBGene00039226; Cbr-glod-4.
DR   eggNOG; KOG2943; Eukaryota.
DR   HOGENOM; CLU_044479_0_0_1; -.
DR   InParanoid; A8XX92; -.
DR   OMA; GCEAACN; -.
DR   OrthoDB; 824414at2759; -.
DR   Proteomes; UP000008549; Chromosome III.
DR   GO; GO:0008340; P:determination of adult lifespan; ISS:UniProtKB.
DR   GO; GO:0009438; P:methylglyoxal metabolic process; ISS:UniProtKB.
DR   CDD; cd16357; GLOD4_C; 1.
DR   Gene3D; 3.10.180.10; -; 2.
DR   InterPro; IPR043193; GLOD4.
DR   InterPro; IPR043194; GLOD4_C.
DR   InterPro; IPR029068; Glyas_Bleomycin-R_OHBP_Dase.
DR   InterPro; IPR004360; Glyas_Fos-R_dOase_dom.
DR   InterPro; IPR037523; VOC.
DR   PANTHER; PTHR46466; PTHR46466; 1.
DR   Pfam; PF00903; Glyoxalase; 1.
DR   SUPFAM; SSF54593; SSF54593; 2.
DR   PROSITE; PS51819; VOC; 2.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat.
FT   CHAIN           1..281
FT                   /note="Glyoxalase 1"
FT                   /id="PRO_0000355119"
FT   DOMAIN          4..127
FT                   /note="VOC 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01163"
FT   DOMAIN          132..251
FT                   /note="VOC 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01163"
SQ   SEQUENCE   281 AA;  32087 MW;  0C12B9D498AAEAC6 CRC64;
     MTARALHYVF KVANRAKTID FYTKILEMKV LRHEEFDKGC EASCNGPYDE RWSKTMIGYG
     SEDEHFVLEL TYNYPIHKYE LGNDYRAIVI DSDQLFDKIS RIDHRKSGCG RLAVKDPDGH
     EFKIGKADHA PKVLRVQLNV GDLEKSKKYW NELLGMGIVE EKKTRVRLSF GEGQCELEIV
     QSGEKIDRKT GFGRIAFSLP GEKLQPLQDK IKSANGTIIN ELLTLKTPGK ADVQVVILAD
     PDAHEICFVG DEGFRDLSKI DDAAEKELRE QIQKDDSEKW Y