ID   GLOD4_RAT               Reviewed;         298 AA.
AC   Q5I0D1;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Glyoxalase domain-containing protein 4;
GN   Name=Glod4;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PROTEIN SEQUENCE OF 131-140, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=Sprague-Dawley; TISSUE=Brain;
RA   Lubec G., Kang S.U.;
RL   Submitted (JUL-2007) to UniProtKB.
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- SUBUNIT: Interacts with NUDT9. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the glyoxalase I family. {ECO:0000305}.
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DR   EMBL; BC088458; AAH88458.1; -; mRNA.
DR   RefSeq; NP_001014249.1; NM_001014227.1.
DR   AlphaFoldDB; Q5I0D1; -.
DR   SMR; Q5I0D1; -.
DR   STRING; 10116.ENSRNOP00000010386; -.
DR   iPTMnet; Q5I0D1; -.
DR   PhosphoSitePlus; Q5I0D1; -.
DR   SwissPalm; Q5I0D1; -.
DR   jPOST; Q5I0D1; -.
DR   PaxDb; Q5I0D1; -.
DR   PRIDE; Q5I0D1; -.
DR   GeneID; 363644; -.
DR   KEGG; rno:363644; -.
DR   CTD; 51031; -.
DR   RGD; 1307010; Glod4.
DR   VEuPathDB; HostDB:ENSRNOG00000007788; -.
DR   eggNOG; KOG2943; Eukaryota.
DR   HOGENOM; CLU_044479_0_0_1; -.
DR   InParanoid; Q5I0D1; -.
DR   OMA; GCEAACN; -.
DR   OrthoDB; 824414at2759; -.
DR   PhylomeDB; Q5I0D1; -.
DR   PRO; PR:Q5I0D1; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000007788; Expressed in stomach and 20 other tissues.
DR   Genevisible; Q5I0D1; RN.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   CDD; cd16357; GLOD4_C; 1.
DR   Gene3D; 3.10.180.10; -; 2.
DR   InterPro; IPR043193; GLOD4.
DR   InterPro; IPR043194; GLOD4_C.
DR   InterPro; IPR029068; Glyas_Bleomycin-R_OHBP_Dase.
DR   InterPro; IPR037523; VOC.
DR   PANTHER; PTHR46466; PTHR46466; 1.
DR   SUPFAM; SSF54593; SSF54593; 1.
DR   PROSITE; PS51819; VOC; 2.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Mitochondrion; Phosphoprotein;
KW   Reference proteome; Repeat.
FT   CHAIN           1..298
FT                   /note="Glyoxalase domain-containing protein 4"
FT                   /id="PRO_0000280393"
FT   DOMAIN          5..130
FT                   /note="VOC 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01163"
FT   DOMAIN          137..258
FT                   /note="VOC 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01163"
FT   MOD_RES         109
FT                   /note="N6-succinyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9CPV4"
FT   MOD_RES         131
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         273
FT                   /note="N6-succinyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9CPV4"
SQ   SEQUENCE   298 AA;  33268 MW;  17D91F9093EBDA80 CRC64;
     MVTRRALHFV FKVGNRFQTV HFFRDVLGMQ VLRHEEFEEG CKAACNGPYD GKWSKTMVGF
     GPEDDHFVAE LTYNYGIGDY KLGNDFMGLT LASSQAVSNA RRLEWPLSKV AEGVFETEAP
     GGYKFYLQDR SPSQSDPVLK VTLAVSDLQK SLNYWSNLLG MKIYEQDEEK KWALLGYADD
     QCKLELQGIQ GAVDHSAAFG RIAFSCPQKE LPDLEDLMKR ESQSILTPLV SLDTPGKATV
     QVVILADPDG HEICFVGDEA FRELSKMDPK GSKLLDDAMA ADKSDEWFAT RNKPKASG