AMDR_ASPFU
ID AMDR_ASPFU Reviewed; 772 AA.
AC Q4WK35;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Acetamidase regulatory protein;
GN Name=amdR; ORFNames=AFUA_1G03860;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Positively regulates the expression of genes involved in the
CC catabolism of certain amides, omega amino acids, and lactams.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR EMBL; AAHF01000007; EAL88097.1; -; Genomic_DNA.
DR RefSeq; XP_750135.1; XM_745042.1.
DR AlphaFoldDB; Q4WK35; -.
DR SMR; Q4WK35; -.
DR STRING; 330879.Q4WK35; -.
DR EnsemblFungi; EAL88097; EAL88097; AFUA_1G03860.
DR GeneID; 3507372; -.
DR KEGG; afm:AFUA_1G03860; -.
DR VEuPathDB; FungiDB:Afu1g03860; -.
DR HOGENOM; CLU_006329_4_0_1; -.
DR InParanoid; Q4WK35; -.
DR OMA; QEDLRMA; -.
DR OrthoDB; 917119at2759; -.
DR Proteomes; UP000002530; Chromosome 1.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR007219; Transcription_factor_dom_fun.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF04082; Fungal_trans; 1.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00906; Fungal_trans; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..772
FT /note="Acetamidase regulatory protein"
FT /id="PRO_0000233115"
FT DNA_BIND 26..59
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 78..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 114..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..662
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..690
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 772 AA; 87414 MW; 47421977B4717B42 CRC64;
MSSTAQKNSL SPTGNGVTKR KSGSAACVHC HRRKVRCDAR IVGLPCSNCR SSGKTDCRIH
EKKKRLAVRS ILNPVPIRCR PPSTSEHVPE ASPPSTISEP TAFTTAFRGV QPEAAAPPAS
VAPNVQSKAQ HLHSNSYSQT SPQAQECHLP PASDRFAEQD AHADFEKRLV KLIDDEEGSG
PREIQRGVRA IYVGHELSNM SFLIRQQRDK DDDVYHFAGS EIPRRQLKTG HDQLLVDALT
LPEPALVDEL VQAYFTHVNP GYPIVEEDQF MSQYRNRDPS DPPPILLLQA ILLVGCHVTH
PKEERDALKA IFFRRAKWLF DNRIERNRDT LVQAALLLTW HSDSPDDDVS ANAHYWVGVA
ARIATGLGMH RNPVSSRFAP RDRRMWRRLW YILVQLDVMV SLSYGRPQAI NLEDSDVSPL
TASDFEGCGA RVQTDYVIHF SELCTMISYI VRERFGLRVS SERRKAALQE ADEALANWSL
RLPDHLRLRA SDMDPWSAML HLTYNNFLIL LHRPHPRASA YSDDYGPHDA EICSAAAGVI
TSIFEELRLN DRLKYLWYSG VHTLFTAMIQ VRVELRFSNP VLAINALRRF DSASCSLREL
AKYWSHATTI LRLFEDSKRL QKDLRLATSE RSRPFSSTQD QPQAQALDQN KNQHQHSSAD
APVQPPQPDR LLPSYDSPTP DSTSLPQTAV SPHQNLTFDS WIPSTNLATV DPMDQPREFL
DWRQLFSFTD PDQPVLPMSM DGLPELEDEW RQIYWQETPM SDLLQDGGWM HG
