AMDR_ASPOR
ID AMDR_ASPOR Reviewed; 775 AA.
AC Q06157; Q00225; Q2UK40;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 2.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=Acetamidase regulatory protein;
GN Name=amdR; ORFNames=AO090003000962;
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=A1560 / IFO 4177;
RX PubMed=1452021; DOI=10.1016/0378-1119(92)90042-n;
RA Wang X.W., Hynes M.J., Davis M.A.;
RT "Structural and functional analysis of the amdR regulatory gene of
RT Aspergillus oryzae.";
RL Gene 122:147-154(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40;
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
CC -!- FUNCTION: Positively regulates the expression of genes involved in the
CC catabolism of certain amides, omega amino acids, and lactams.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- INDUCTION: By omega amino acids.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA32686.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; M96953; AAA32686.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP007155; BAE58075.1; -; Genomic_DNA.
DR PIR; JQ1956; JQ1956.
DR RefSeq; XP_001820077.1; XM_001820025.2.
DR AlphaFoldDB; Q06157; -.
DR STRING; 510516.Q06157; -.
DR EnsemblFungi; BAE58075; BAE58075; AO090003000962.
DR GeneID; 5992060; -.
DR KEGG; aor:AO090003000962; -.
DR VEuPathDB; FungiDB:AO090003000962; -.
DR HOGENOM; CLU_006329_4_0_1; -.
DR OMA; QEDLRMA; -.
DR Proteomes; UP000006564; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR007219; Transcription_factor_dom_fun.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF04082; Fungal_trans; 1.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00906; Fungal_trans; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation; Zinc.
FT CHAIN 1..775
FT /note="Acetamidase regulatory protein"
FT /id="PRO_0000114935"
FT DNA_BIND 26..59
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 126..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 630..699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..675
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..690
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 727..728
FT /note="QL -> PV (in Ref. 1; AAA32686)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 775 AA; 88137 MW; 7F2EA51E760AB050 CRC64;
MSSTAHNSQP STGNGVTKRK SGSAACIHCH RRKVRCDARI VGLPCSNCRS AGKADCRIHE
KKKRLAVRSI LDPVPIRCRP PPDSDSTPKL LPSTPIQPNA FTTAFRGVQP DVTSPVAAGA
QIIQSPHSSY TNGNHLSNNR GSQPITETQT FTRQPGADRS MELENNADLE KRLVKLIDEE
ESGSREIQRG VRAIYVGHEL SNMSFLIRQQ RDKDDDVYHF AGNEIPRRQL RTGHDQLLMD
ALTLPEPALA DELVEAYFMH VNPGYPIIEE DLFMTQYRNR DPADPPPILL LQAILLVGAH
VTRPKAERDA LKEIFFRRVK WLFDSRIERN RDIMVQAALL MTWHSDSADD DVAANAHYWV
GVAARIATGL GMHRNPVSSK FVPRDRRMWR RLWYILVQFD VMVSLSYGRP QAINLEDSDV
SPLTPSDFEG CGSRVQAEYV IHFSELCTMI PYIVRERFGL RVSAERRKAA LQEADEALAN
WSLKLPDSLR LRASDMDPWS AMLHLTYNNF LILLHRPHPR ASAYSDDYGP HDAEICSAAA
GVIASIFEEL RLNDRLKFLW YSGVHTLFTA MIQVRVELRF SNPVLAINAL RRFDSASYSL
RELAEYWSHA NTILRLFQDS KRLQEDLRMA TSERPRRFST HDQNKNTTNP SNPHPTPTPN
LNSNTTIQSA QTEPRPPYEV PTPESPRMPP TTMSPHQNQP FDSWIPSSHL ASVDPIDQPR
EFLDWRQLFS FTDPDQSVLP VPMEGLPELE DEWRQIYWQE TPMSDLLQDG GWMHG
