ID   GLP1_CITSI              Reviewed;          25 AA.
AC   P84159;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   11-DEC-2019, entry version 35.
DE   RecName: Full=Germin-like protein;
DE   AltName: Allergen=Cit s 1;
DE   Flags: Fragment;
OS   Citrus sinensis (Sweet orange) (Citrus aurantium var. sinensis).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Citrus.
OX   NCBI_TaxID=2711;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, MASS SPECTROMETRY, AND ALLERGEN.
RX   PubMed=16357490; DOI=10.1159/000090384;
RA   Ahrazem O., Ibanez M.D., Lopez-Torrejon G., Sanchez-Monge R., Sastre J.,
RA   Lombardero M., Barber D., Salcedo G.;
RT   "Orange germin-like glycoprotein Cit s 1: an equivocal allergen.";
RL   Int. Arch. Allergy Immunol. 139:96-103(2006).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-15, AND ALLERGEN.
RC   TISSUE=Fruit flesh;
RX   PubMed=16521162; DOI=10.1002/mnfr.200500200;
RA   Crespo J.F., Retzek M., Foetisch K., Sierra-Maestro E., Cid-Sanchez A.B.,
RA   Pascual C.Y., Conti A., Feliu A., Rodriguez J., Vieths S., Scheurer S.;
RT   "Germin-like protein Cit s 1 and profilin Cit s 2 are major allergens in
RT   orange (Citrus sinensis) fruits.";
RL   Mol. Nutr. Food Res. 50:282-290(2006).
CC   -!- FUNCTION: May play a role in plant defense. Probably has no oxalate
CC       oxidase activity even if the active site is conserved. {ECO:0000305}.
CC   -!- SUBUNIT: Oligomer (believed to be a pentamer but probably hexamer).
CC       {ECO:0000250|UniProtKB:Q9FL89}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, apoplast
CC       {ECO:0000250|UniProtKB:Q9FL89}.
CC   -!- PTM: The three different mass spectrometry results appear to arise from
CC       different glycosylation variants. {ECO:0000269|PubMed:16357490}.
CC   -!- MASS SPECTROMETRY: Mass=23094; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:16357490};
CC   -!- MASS SPECTROMETRY: Mass=23298; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:16357490};
CC   -!- MASS SPECTROMETRY: Mass=23504; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:16357490};
CC   -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE.
CC       {ECO:0000269|PubMed:16357490, ECO:0000269|PubMed:16521162}.
CC   -!- SIMILARITY: Belongs to the germin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   Allergome; 1640; Cit s 1.
DR   Allergome; 3199; Cit s 1.0101.
DR   GO; GO:0048046; C:apoplast; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Allergen; Apoplast; Direct protein sequencing; Manganese; Metal-binding;
KW   Secreted.
FT   CHAIN           1..>25
FT                   /note="Germin-like protein"
FT                   /id="PRO_0000192015"
FT   NON_TER         25
FT                   /evidence="ECO:0000303|PubMed:16357490"
SQ   SEQUENCE   25 AA;  2743 MW;  09C6AF55079BB8E1 CRC64;
     TDPGHLQDVX VAINDPKXGV FVNRK