GLP2R_HUMAN
ID GLP2R_HUMAN Reviewed; 553 AA.
AC O95838; Q4VAT3;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Glucagon-like peptide 2 receptor;
DE Short=GLP-2 receptor;
DE Short=GLP-2-R;
DE Short=GLP-2R;
GN Name=GLP2R;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Stomach;
RX PubMed=9990065; DOI=10.1073/pnas.96.4.1569;
RA Munroe D.G., Gupta A.K., Kooshesh F., Vyas T.B., Rizkalla G., Wang H.,
RA Demchyshyn L., Yang Z.-H., Kamboj R.K., Chen H., McCallum K.,
RA Sumner-Smith M., Drucker D.J., Crivici A.;
RT "Prototypic G protein-coupled receptor for the intestinotrophic factor
RT glucagon-like peptide 2.";
RL Proc. Natl. Acad. Sci. U.S.A. 96:1569-1573(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASN-470.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: This is a receptor for glucagon-like peptide 2. The activity
CC of this receptor is mediated by G proteins which activate adenylyl
CC cyclase.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC {ECO:0000305}.
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DR EMBL; AF105367; AAD16895.1; -; mRNA.
DR EMBL; BC096262; AAH96262.1; -; mRNA.
DR CCDS; CCDS11150.1; -.
DR RefSeq; NP_004237.1; NM_004246.2.
DR PDB; 7D68; EM; 3.00 A; R=1-490.
DR PDBsum; 7D68; -.
DR AlphaFoldDB; O95838; -.
DR SMR; O95838; -.
DR BioGRID; 114746; 2.
DR IntAct; O95838; 1.
DR MINT; O95838; -.
DR STRING; 9606.ENSP00000262441; -.
DR BindingDB; O95838; -.
DR ChEMBL; CHEMBL5844; -.
DR DrugBank; DB00040; Glucagon.
DR DrugBank; DB08900; Teduglutide.
DR DrugCentral; O95838; -.
DR GuidetoPHARMACOLOGY; 250; -.
DR GlyGen; O95838; 4 sites.
DR iPTMnet; O95838; -.
DR PhosphoSitePlus; O95838; -.
DR BioMuta; GLP2R; -.
DR MassIVE; O95838; -.
DR PaxDb; O95838; -.
DR PeptideAtlas; O95838; -.
DR PRIDE; O95838; -.
DR ProteomicsDB; 51084; -.
DR Antibodypedia; 12679; 375 antibodies from 34 providers.
DR DNASU; 9340; -.
DR Ensembl; ENST00000262441.10; ENSP00000262441.5; ENSG00000065325.13.
DR GeneID; 9340; -.
DR KEGG; hsa:9340; -.
DR MANE-Select; ENST00000262441.10; ENSP00000262441.5; NM_004246.3; NP_004237.1.
DR UCSC; uc002gmd.2; human.
DR CTD; 9340; -.
DR DisGeNET; 9340; -.
DR GeneCards; GLP2R; -.
DR HGNC; HGNC:4325; GLP2R.
DR HPA; ENSG00000065325; Tissue enhanced (gallbladder, intestine, urinary bladder).
DR MIM; 603659; gene.
DR neXtProt; NX_O95838; -.
DR OpenTargets; ENSG00000065325; -.
DR PharmGKB; PA28726; -.
DR VEuPathDB; HostDB:ENSG00000065325; -.
DR eggNOG; KOG4564; Eukaryota.
DR GeneTree; ENSGT00940000158127; -.
DR HOGENOM; CLU_002753_4_0_1; -.
DR InParanoid; O95838; -.
DR OMA; STDIWRD; -.
DR OrthoDB; 651627at2759; -.
DR PhylomeDB; O95838; -.
DR TreeFam; TF315710; -.
DR PathwayCommons; O95838; -.
DR Reactome; R-HSA-418555; G alpha (s) signalling events.
DR Reactome; R-HSA-420092; Glucagon-type ligand receptors.
DR Reactome; R-HSA-9660821; ADORA2B mediated anti-inflammatory cytokines production.
DR SignaLink; O95838; -.
DR BioGRID-ORCS; 9340; 15 hits in 1072 CRISPR screens.
DR GeneWiki; Glucagon-like_peptide_2_receptor; -.
DR GenomeRNAi; 9340; -.
DR Pharos; O95838; Tclin.
DR PRO; PR:O95838; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; O95838; protein.
DR Bgee; ENSG00000065325; Expressed in colonic epithelium and 84 other tissues.
DR ExpressionAtlas; O95838; baseline and differential.
DR Genevisible; O95838; HS.
DR GO; GO:0016021; C:integral component of membrane; TAS:ProtInc.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0008528; F:G protein-coupled peptide receptor activity; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; TAS:ProtInc.
DR GO; GO:0004967; F:glucagon receptor activity; IBA:GO_Central.
DR GO; GO:0017046; F:peptide hormone binding; IBA:GO_Central.
DR GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; TAS:ProtInc.
DR Gene3D; 4.10.1240.10; -; 1.
DR InterPro; IPR039125; GLP2R.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR PANTHER; PTHR45620:SF23; PTHR45620:SF23; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF02793; HRM; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00008; HormR; 1.
DR SUPFAM; SSF111418; SSF111418; 1.
DR PROSITE; PS00649; G_PROTEIN_RECEP_F2_1; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Disulfide bond; G-protein coupled receptor;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..553
FT /note="Glucagon-like peptide 2 receptor"
FT /id="PRO_0000012838"
FT TOPO_DOM 1..173
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 174..198
FT /note="Helical; Name=1"
FT /evidence="ECO:0000250"
FT TOPO_DOM 199..210
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 211..235
FT /note="Helical; Name=2"
FT /evidence="ECO:0000250"
FT TOPO_DOM 236..261
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 262..285
FT /note="Helical; Name=3"
FT /evidence="ECO:0000250"
FT TOPO_DOM 286..299
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 300..321
FT /note="Helical; Name=4"
FT /evidence="ECO:0000250"
FT TOPO_DOM 322..339
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 340..362
FT /note="Helical; Name=5"
FT /evidence="ECO:0000250"
FT TOPO_DOM 363..386
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 387..405
FT /note="Helical; Name=6"
FT /evidence="ECO:0000250"
FT TOPO_DOM 406..417
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 418..438
FT /note="Helical; Name=7"
FT /evidence="ECO:0000250"
FT TOPO_DOM 439..550
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT CARBOHYD 97
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 113
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 148
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 162
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 83..105
FT /evidence="ECO:0000250"
FT DISULFID 96..137
FT /evidence="ECO:0000250"
FT DISULFID 118..159
FT /evidence="ECO:0000250"
FT VARIANT 22
FT /note="H -> L (in dbSNP:rs8072568)"
FT /id="VAR_033967"
FT VARIANT 470
FT /note="D -> N (in dbSNP:rs17681684)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_033968"
FT VARIANT 523
FT /note="R -> H (in dbSNP:rs16958918)"
FT /id="VAR_033969"
FT HELIX 167..202
FT /evidence="ECO:0007829|PDB:7D68"
FT HELIX 209..238
FT /evidence="ECO:0007829|PDB:7D68"
FT HELIX 253..256
FT /evidence="ECO:0007829|PDB:7D68"
FT HELIX 259..287
FT /evidence="ECO:0007829|PDB:7D68"
FT STRAND 290..292
FT /evidence="ECO:0007829|PDB:7D68"
FT TURN 300..302
FT /evidence="ECO:0007829|PDB:7D68"
FT HELIX 303..307
FT /evidence="ECO:0007829|PDB:7D68"
FT HELIX 312..324
FT /evidence="ECO:0007829|PDB:7D68"
FT STRAND 336..338
FT /evidence="ECO:0007829|PDB:7D68"
FT HELIX 341..370
FT /evidence="ECO:0007829|PDB:7D68"
FT HELIX 376..394
FT /evidence="ECO:0007829|PDB:7D68"
FT HELIX 399..403
FT /evidence="ECO:0007829|PDB:7D68"
FT HELIX 412..436
FT /evidence="ECO:0007829|PDB:7D68"
FT TURN 437..439
FT /evidence="ECO:0007829|PDB:7D68"
FT HELIX 441..451
FT /evidence="ECO:0007829|PDB:7D68"
SQ SEQUENCE 553 AA; 63001 MW; DA37379DF774A8F4 CRC64;
MKLGSSRAGP GRGSAGLLPG VHELPMGIPA PWGTSPLSFH RKCSLWAPGR PFLTLVLLVS
IKQVTGSLLE ETTRKWAQYK QACLRDLLKE PSGIFCNGTF DQYVCWPHSS PGNVSVPCPS
YLPWWSEESS GRAYRHCLAQ GTWQTIENAT DIWQDDSECS ENHSFKQNVD RYALLSTLQL
MYTVGYSFSL ISLFLALTLL LFLRKLHCTR NYIHMNLFAS FILRTLAVLV KDVVFYNSYS
KRPDNENGWM SYLSEMSTSC RSVQVLLHYF VGANYLWLLV EGLYLHTLLE PTVLPERRLW
PRYLLLGWAF PVLFVVPWGF ARAHLENTGC WTTNGNKKIW WIIRGPMMLC VTVNFFIFLK
ILKLLISKLK AHQMCFRDYK YRLAKSTLVL IPLLGVHEIL FSFITDDQVE GFAKLIRLFI
QLTLSSFHGF LVALQYGFAN GEVKAELRKY WVRFLLARHS GCRACVLGKD FRFLGKCPKK
LSEGDGAEKL RKLQPSLNSG RLLHLAMRGL GELGAQPQQD HARWPRGSSL SECSEGDVTM
ANTMEEILEE SEI
