GLP2R_MOUSE
ID GLP2R_MOUSE Reviewed; 512 AA.
AC Q5IXF8; Q5SU65;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Glucagon-like peptide 2 receptor;
DE Short=GLP-2 receptor;
DE Short=GLP-2-R;
DE Short=GLP-2R;
GN Name=Glp2r;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Jejunum;
RA Estall J.L., Drucker D.J.;
RT "Murine glucagon-like peptide-2 receptor cDNA.";
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: This is a receptor for glucagon-like peptide 2. The activity
CC of this receptor is mediated by G proteins which activate adenylyl
CC cyclase (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC {ECO:0000305}.
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DR EMBL; AY605231; AAT46060.1; -; mRNA.
DR EMBL; AL646097; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS24860.1; -.
DR RefSeq; NP_783612.2; NM_175681.3.
DR AlphaFoldDB; Q5IXF8; -.
DR SMR; Q5IXF8; -.
DR STRING; 10090.ENSMUSP00000061560; -.
DR GlyGen; Q5IXF8; 1 site.
DR PhosphoSitePlus; Q5IXF8; -.
DR PaxDb; Q5IXF8; -.
DR PRIDE; Q5IXF8; -.
DR ProteomicsDB; 263368; -.
DR Antibodypedia; 12679; 375 antibodies from 34 providers.
DR DNASU; 93896; -.
DR Ensembl; ENSMUST00000051765; ENSMUSP00000061560; ENSMUSG00000049928.
DR GeneID; 93896; -.
DR KEGG; mmu:93896; -.
DR UCSC; uc007jna.1; mouse.
DR CTD; 9340; -.
DR MGI; MGI:2136733; Glp2r.
DR VEuPathDB; HostDB:ENSMUSG00000049928; -.
DR eggNOG; KOG4564; Eukaryota.
DR GeneTree; ENSGT00940000158127; -.
DR HOGENOM; CLU_002753_4_0_1; -.
DR InParanoid; Q5IXF8; -.
DR OMA; STDIWRD; -.
DR OrthoDB; 651627at2759; -.
DR PhylomeDB; Q5IXF8; -.
DR TreeFam; TF315710; -.
DR Reactome; R-MMU-418555; G alpha (s) signalling events.
DR Reactome; R-MMU-420092; Glucagon-type ligand receptors.
DR BioGRID-ORCS; 93896; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Glp2r; mouse.
DR PRO; PR:Q5IXF8; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q5IXF8; protein.
DR Bgee; ENSMUSG00000049928; Expressed in retinal neural layer and 23 other tissues.
DR ExpressionAtlas; Q5IXF8; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0008528; F:G protein-coupled peptide receptor activity; IBA:GO_Central.
DR GO; GO:0004967; F:glucagon receptor activity; ISO:MGI.
DR GO; GO:0017046; F:peptide hormone binding; IBA:GO_Central.
DR GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; ISO:MGI.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 4.10.1240.10; -; 1.
DR InterPro; IPR039125; GLP2R.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR PANTHER; PTHR45620:SF23; PTHR45620:SF23; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF02793; HRM; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00008; HormR; 1.
DR SUPFAM; SSF111418; SSF111418; 1.
DR PROSITE; PS00649; G_PROTEIN_RECEP_F2_1; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..512
FT /note="Glucagon-like peptide 2 receptor"
FT /id="PRO_0000307111"
FT TOPO_DOM 1..135
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 136..160
FT /note="Helical; Name=1"
FT /evidence="ECO:0000250"
FT TOPO_DOM 161..172
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 173..197
FT /note="Helical; Name=2"
FT /evidence="ECO:0000250"
FT TOPO_DOM 198..223
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 224..247
FT /note="Helical; Name=3"
FT /evidence="ECO:0000250"
FT TOPO_DOM 248..261
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 262..283
FT /note="Helical; Name=4"
FT /evidence="ECO:0000250"
FT TOPO_DOM 284..301
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 302..324
FT /note="Helical; Name=5"
FT /evidence="ECO:0000250"
FT TOPO_DOM 325..348
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 349..367
FT /note="Helical; Name=6"
FT /evidence="ECO:0000250"
FT TOPO_DOM 368..379
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 380..400
FT /note="Helical; Name=7"
FT /evidence="ECO:0000250"
FT TOPO_DOM 401..512
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT REGION 458..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 73
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 43..65
FT /evidence="ECO:0000250"
FT DISULFID 56..97
FT /evidence="ECO:0000250"
FT DISULFID 78..119
FT /evidence="ECO:0000250"
FT CONFLICT 263
FT /note="P -> H (in Ref. 1; AAT46060)"
FT /evidence="ECO:0000305"
FT CONFLICT 459..460
FT /note="GV -> AF (in Ref. 1; AAT46060)"
FT /evidence="ECO:0000305"
FT CONFLICT 485
FT /note="R -> L (in Ref. 1; AAT46060)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 512 AA; 59105 MW; B7CBEE79F0267867 CRC64;
MRRLWGPGTP FLALLLLVSI KQVTTGSLLE ETVQKWAQYK ETCLKDLLEK PSGVFCNGTF
DKYVCWPHSF PGNVSVPCPS YLPWWNKESP GRAYRHCLAQ GTWQKQENST DTWQDESECS
ENHSFKQNVD HYHHTLLSTL QLMYTVGYSL SLISLFLALT LFLFLRKLHC TRNYIHMNLF
ASFILRALVV LVKDMVFYNS YSRRPDSESG WMSYLSEISA SCRSVQVLLH YFVGTNHLWL
LVEGLYLHAL LEPTVLPERR LWPKYLVVGW AFPMLFVIPW IFVRASLENT GCWAVNENKK
IWWIIRGPIL LCVTVNFFIF LKILKLLISK FRAHQMCFRD YKYRLAKSTL LLILLMGVHE
FLFTFFTDDQ VQGFSRLIRL FIQLTLSSFH GFLVALQYGF ASREVKAELR KTWGRFLLAR
HWGCRACVLG KNFRFLGKCS KKLSEGDGAE TLQKLQSSGV SSHLTAGNLR DHGAQPHRGR
GAWPRASSLS ESSEGDFTLA NTMEEILEES EI
