ID   GLP3L_XENTR             Reviewed;         280 AA.
AC   Q5U4Q6;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Golgi phosphoprotein 3-like;
GN   Name=golph3l; ORFNames=TEgg035m19.1, TEgg061g02.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Phosphatidylinositol-4-phosphate-binding protein that may
CC       play a role in the process of vesicle budding at the Golgi and
CC       anterograde transport to the plasma membrane. {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Note=Phosphatidylinositol 4-phosphate (PtdIns4P)-
CC       binding mediates recruitment to Golgi membranes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GOLPH3/VPS74 family. {ECO:0000305}.
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DR   EMBL; CR761980; CAJ81394.1; -; mRNA.
DR   EMBL; CR848444; CAJ83698.1; -; mRNA.
DR   EMBL; BC084991; AAH84991.1; -; mRNA.
DR   RefSeq; NP_001011166.1; NM_001011166.2.
DR   AlphaFoldDB; Q5U4Q6; -.
DR   SMR; Q5U4Q6; -.
DR   PaxDb; Q5U4Q6; -.
DR   DNASU; 496584; -.
DR   GeneID; 496584; -.
DR   KEGG; xtr:496584; -.
DR   CTD; 55204; -.
DR   Xenbase; XB-GENE-1003088; golph3l.
DR   eggNOG; KOG3983; Eukaryota.
DR   HOGENOM; CLU_036311_0_0_1; -.
DR   InParanoid; Q5U4Q6; -.
DR   OMA; APCVYLS; -.
DR   OrthoDB; 1117244at2759; -.
DR   TreeFam; TF314360; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000008912; Expressed in 4-cell stage embryo and 15 other tissues.
DR   ExpressionAtlas; Q5U4Q6; baseline.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0031985; C:Golgi cisterna; ISS:UniProtKB.
DR   GO; GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:GOC.
DR   GO; GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
DR   GO; GO:0070273; F:phosphatidylinositol-4-phosphate binding; ISS:UniProtKB.
DR   GO; GO:0007030; P:Golgi organization; ISS:UniProtKB.
DR   GO; GO:0043001; P:Golgi to plasma membrane protein transport; IBA:GO_Central.
DR   GO; GO:0048194; P:Golgi vesicle budding; IBA:GO_Central.
DR   GO; GO:0050714; P:positive regulation of protein secretion; ISS:UniProtKB.
DR   GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IBA:GO_Central.
DR   Gene3D; 1.10.3630.10; -; 1.
DR   InterPro; IPR008628; GPP34-like.
DR   InterPro; IPR038261; GPP34-like_sf.
DR   PANTHER; PTHR12704; PTHR12704; 1.
DR   Pfam; PF05719; GPP34; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Lipid-binding; Membrane; Reference proteome.
FT   CHAIN           1..280
FT                   /note="Golgi phosphoprotein 3-like"
FT                   /id="PRO_0000324141"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          171..182
FT                   /note="Beta-hairpin required for oligomerization"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        9..30
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         62
FT                   /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol
FT                   4-phosphate)"
FT                   /ligand_id="ChEBI:CHEBI:58178"
FT                   /evidence="ECO:0000250"
FT   BINDING         71
FT                   /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol
FT                   4-phosphate)"
FT                   /ligand_id="ChEBI:CHEBI:58178"
FT                   /evidence="ECO:0000250"
FT   BINDING         152
FT                   /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol
FT                   4-phosphate)"
FT                   /ligand_id="ChEBI:CHEBI:58178"
FT                   /evidence="ECO:0000250"
FT   BINDING         155
FT                   /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol
FT                   4-phosphate)"
FT                   /ligand_id="ChEBI:CHEBI:58178"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   280 AA;  32289 MW;  E3D6B7151656EE55 CRC64;
     MTTLTRRGRR ADVGQENRVD SEDYIKDKDE EESADSKDIR LTLMEEVLLL GLKDKEGYTS
     FWNDCISSGL RGGILIELFL RNRVVLEPST LRKKRLTDRK VLLKSDTPTG DVLLDETLKH
     MKATEPAETV QSWIELLTGE TWNPFKLQYQ LRNVRERIAK NLVEKGILTT EKQNFLLFDM
     TTHPVSNTTE KQRLVKKLQE SLLEKWVNDP HRMDRRTLAL LVLAHSSDVL ENAFSSLSDE
     KYDMAMTRSK ELLDLDPDTE GNKPNTCEMI WAVLSAFNKS