GLPA_HORSE
ID GLPA_HORSE Reviewed; 120 AA.
AC P02726;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Glycophorin-A;
DE AltName: Full=Glycophorin-HA;
DE AltName: CD_antigen=CD235a;
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796;
RN [1]
RP PROTEIN SEQUENCE, AND PYROGLUTAMATE FORMATION AT GLN-1.
RX PubMed=7057453; DOI=10.1007/bf01870887;
RA Murayama J., Tomita M., Hamada A.;
RT "Primary structure of horse erythrocyte glycophorin HA. Its amino acid
RT sequence has a unique homology with those of human and porcine erythrocyte
RT glycophorins.";
RL J. Membr. Biol. 64:205-215(1982).
CC -!- FUNCTION: Glycophorin A is the major intrinsic membrane
CC sialoglycoprotein of the erythrocyte. Appears to be important for the
CC function of SLC4A1 and is required for high activity of SLC4A1. May be
CC involved in translocation of SLC4A1 to the plasma membrane (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC -!- SIMILARITY: Belongs to the glycophorin-A family. {ECO:0000305}.
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DR PIR; A03185; GFHOE.
DR AlphaFoldDB; P02726; -.
DR SMR; P02726; -.
DR GlyConnect; 180; 5 O-Linked glycans.
DR iPTMnet; P02726; -.
DR Proteomes; UP000002281; Unplaced.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR InterPro; IPR001195; Glycophorin.
DR InterPro; IPR018938; Glycophorin_CS.
DR PANTHER; PTHR13813; PTHR13813; 1.
DR PROSITE; PS00312; GLYCOPHORIN_A; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Glycoprotein; Membrane; Phosphoprotein;
KW Pyrrolidone carboxylic acid; Reference proteome; Sialic acid;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..120
FT /note="Glycophorin-A"
FT /id="PRO_0000149046"
FT TRANSMEM 50..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 78..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:7057453"
FT MOD_RES 119
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02724"
FT CARBOHYD 2
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000269|PubMed:7057453"
FT CARBOHYD 5
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000269|PubMed:7057453"
FT CARBOHYD 7
FT /note="O-linked (GalNAc...) serine"
FT /evidence="ECO:0000269|PubMed:7057453"
FT CARBOHYD 13
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000269|PubMed:7057453"
FT CARBOHYD 17
FT /note="O-linked (GalNAc...) serine"
FT /evidence="ECO:0000269|PubMed:7057453"
FT CARBOHYD 18
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000269|PubMed:7057453"
FT CARBOHYD 20
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000269|PubMed:7057453"
FT CARBOHYD 21
FT /note="O-linked (GalNAc...) serine"
FT /evidence="ECO:0000269|PubMed:7057453"
FT CARBOHYD 24
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000269|PubMed:7057453"
FT CARBOHYD 28
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000269|PubMed:7057453"
SQ SEQUENCE 120 AA; 12440 MW; 683EEF1090F4D99C CRC64;
QTIATGSPPI AGTSDLSTIT SAATPTFTTE QDGREQGDGL QLAHDFSQPV ITVIILGVMA
GIIGIILLLA YVSRRLRKRP PADVPPPAST VPSADAPPPV SEDDETSLTS VETDYPGDSQ
