ID   GLPC_MOUSE              Reviewed;          95 AA.
AC   Q78HU7; Q6XFR5;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Glycophorin-C;
DE   AltName: CD_antigen=CD236;
GN   Name=Gypc;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Chen Y., Peng J., Huang C.-H.;
RT   "Sequence and evolution of glycophorin C (GPC) proteins.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-78, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brown adipose tissue, Heart, Liver, Lung, and Spleen;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type III
CC       membrane protein {ECO:0000250}. Note=Linked to the membrane via band
CC       4.1. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the glycophorin-C family. {ECO:0000305}.
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DR   EMBL; AY234183; AAP70024.1; -; mRNA.
DR   EMBL; BC027408; AAH27408.2; -; mRNA.
DR   CCDS; CCDS57118.1; -.
DR   RefSeq; NP_001041672.1; NM_001048207.1.
DR   AlphaFoldDB; Q78HU7; -.
DR   SMR; Q78HU7; -.
DR   STRING; 10090.ENSMUSP00000134317; -.
DR   iPTMnet; Q78HU7; -.
DR   PhosphoSitePlus; Q78HU7; -.
DR   EPD; Q78HU7; -.
DR   MaxQB; Q78HU7; -.
DR   PaxDb; Q78HU7; -.
DR   PRIDE; Q78HU7; -.
DR   ProteomicsDB; 266815; -.
DR   Antibodypedia; 2455; 489 antibodies from 34 providers.
DR   DNASU; 71683; -.
DR   Ensembl; ENSMUST00000174459; ENSMUSP00000134317; ENSMUSG00000090523.
DR   GeneID; 71683; -.
DR   KEGG; mmu:71683; -.
DR   UCSC; uc008ejk.1; mouse.
DR   CTD; 2995; -.
DR   MGI; MGI:1098566; Gypc.
DR   VEuPathDB; HostDB:ENSMUSG00000090523; -.
DR   eggNOG; ENOG502S5JS; Eukaryota.
DR   GeneTree; ENSGT00510000049102; -.
DR   InParanoid; Q78HU7; -.
DR   OMA; QPHGDVE; -.
DR   OrthoDB; 1623675at2759; -.
DR   PhylomeDB; Q78HU7; -.
DR   TreeFam; TF337016; -.
DR   BioGRID-ORCS; 71683; 5 hits in 71 CRISPR screens.
DR   ChiTaRS; Gypc; mouse.
DR   PRO; PR:Q78HU7; -.
DR   Proteomes; UP000000589; Chromosome 18.
DR   RNAct; Q78HU7; protein.
DR   Bgee; ENSMUSG00000090523; Expressed in fetal liver hematopoietic progenitor cell and 192 other tissues.
DR   ExpressionAtlas; Q78HU7; baseline and differential.
DR   Genevisible; Q78HU7; MM.
DR   GO; GO:0030863; C:cortical cytoskeleton; IDA:MGI.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IDA:MGI.
DR   GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR   InterPro; IPR042192; Glycophorin-C.
DR   InterPro; IPR003585; Neurexin-like.
DR   PANTHER; PTHR47614; PTHR47614; 1.
DR   SMART; SM00294; 4.1m; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..95
FT                   /note="Glycophorin-C"
FT                   /id="PRO_0000378454"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical; Signal-anchor for type III membrane
FT                   protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..95
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         71
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P04921"
FT   MOD_RES         78
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         89
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P04921"
SQ   SEQUENCE   95 AA;  10329 MW;  BF40FA45AFDF2B46 CRC64;
     MSSPVSKPPP ELLEPNPGKS YGIMEIAIIA AVITAVALVL VCLLFLMLRY LYRHKGTYHT
     NEAKGTEFAE SADAALQSDP ALQDAGDTSK KEYFI