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GLPD1_MYCBO
ID   GLPD1_MYCBO             Reviewed;         516 AA.
AC   P64183; A0A1R3Y2T0; Q10502; X2BK71;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Glycerol-3-phosphate dehydrogenase 1;
DE            EC=1.1.5.3;
GN   Name=glpD1; Synonyms=glpD; OrderedLocusNames=BQ2027_MB2273C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a quinone + sn-glycerol 3-phosphate = a quinol +
CC         dihydroxyacetone phosphate; Xref=Rhea:RHEA:18977, ChEBI:CHEBI:24646,
CC         ChEBI:CHEBI:57597, ChEBI:CHEBI:57642, ChEBI:CHEBI:132124; EC=1.1.5.3;
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FAD-dependent glycerol-3-phosphate
CC       dehydrogenase family. {ECO:0000305}.
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DR   EMBL; LT708304; SIU00884.1; -; Genomic_DNA.
DR   RefSeq; NP_855922.1; NC_002945.3.
DR   RefSeq; WP_003411591.1; NC_002945.4.
DR   AlphaFoldDB; P64183; -.
DR   SMR; P64183; -.
DR   EnsemblBacteria; SIU00884; SIU00884; BQ2027_MB2273C.
DR   PATRIC; fig|233413.5.peg.2494; -.
DR   OMA; GVMTIMN; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0009331; C:glycerol-3-phosphate dehydrogenase complex; IEA:InterPro.
DR   GO; GO:0052591; F:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006071; P:glycerol metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006072; P:glycerol-3-phosphate metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.8.870; -; 1.
DR   Gene3D; 3.50.50.60; -; 1.
DR   InterPro; IPR031656; DAO_C.
DR   InterPro; IPR038299; DAO_C_sf.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR000447; G3P_DH_FAD-dep.
DR   PANTHER; PTHR11985; PTHR11985; 1.
DR   Pfam; PF01266; DAO; 1.
DR   Pfam; PF16901; DAO_C; 1.
DR   PRINTS; PR01001; FADG3PDH.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   PROSITE; PS00977; FAD_G3PDH_1; 1.
DR   PROSITE; PS00978; FAD_G3PDH_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; FAD; Flavoprotein; Glycerol metabolism; Oxidoreductase.
FT   CHAIN           1..516
FT                   /note="Glycerol-3-phosphate dehydrogenase 1"
FT                   /id="PRO_0000126101"
FT   BINDING         28..56
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   516 AA;  54176 MW;  164A136FEEB402E6 CRC64;
     MLMPHSAALN AARRSADLTA LADGGALDVI VIGGGITGVG IALDAATRGL TVALVEKHDL
     AFGTSRWSSK LVHGGLRYLA SGNVGIARRS AVERGILMTR NAPHLVHAMP QLVPLLPSMG
     HTKRALVRAG FLAGDALRVL AGTPAATLPR SRRIPASRVV EIAPTVRRDG LDGGLLAYDG
     QLIDDARLVM AVARTAAQHG ARILTYVGAS NVTGTSVELT DRRTRQSFAL SARAVINAAG
     VWAGEIDPSL RLRPSRGTHL VFDAKSFANP TAALTIPIPG ELNRFVFAMP EQLGRIYLGL
     TDEDAPGPIP DVPQPSSEEI TFLLDTVNTA LGTAVGTKDV IGAYAGLRPL IDTGGAGVQG
     RTADVSRDHA VFESPSGVIS VVGGKLTEYR YMAEDVLNRA ITLRHLRAAK CRTRNLPLIG
     APANPGPAPG SGAGLPESLV ARYGAEAANV AAAATCERPT EPVADGIDVT RAEFEYAVTH
     EGALDVDDIL DRRTRIGLVP RDRERVVAVA KEFLSR
 
 
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