ID   AMELY_BOVIN             Reviewed;         192 AA.
AC   Q99004;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Amelogenin, Y isoform;
DE   AltName: Full=Class II amelogenin;
DE   Flags: Precursor;
GN   Name=AMELY;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   PARTIAL NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1989679; DOI=10.1021/bi00218a028;
RA   Gibson C., Golub E., Herold R., Risser M., Ding W., Shimokawa H., Young M.,
RA   Termine J., Rosenbloom J.;
RT   "Structure and expression of the bovine amelogenin gene.";
RL   Biochemistry 30:1075-1079(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 7-192.
RX   PubMed=1525172; DOI=10.1021/bi00150a036;
RA   Gibson C.W., Golub E.E., Abrams W.R., Shen G., Ding W., Rosenbloom J.;
RT   "Bovine amelogenin message heterogeneity: alternative splicing and Y-
RT   chromosomal gene transcription.";
RL   Biochemistry 31:8384-8388(1992).
CC   -!- FUNCTION: Plays a role in the biomineralization of teeth. Seems to
CC       regulate the formation of crystallites during the secretory stage of
CC       tooth enamel development. Thought to play a major role in the
CC       structural organization and mineralization of developing enamel.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced.;
CC       Name=1;
CC         IsoId=Q99004-1; Sequence=Displayed;
CC   -!- SIMILARITY: Belongs to the amelogenin family. {ECO:0000305}.
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DR   EMBL; M63500; AAA30373.1; -; mRNA.
DR   EMBL; S44231; AAB23270.2; -; mRNA.
DR   PIR; A42931; A42931.
DR   RefSeq; NP_776665.1; NM_174240.2.
DR   AlphaFoldDB; Q99004; -.
DR   STRING; 9913.ENSBTAP00000029893; -.
DR   PaxDb; Q99004; -.
DR   GeneID; 281621; -.
DR   CTD; 266; -.
DR   eggNOG; ENOG502S4XP; Eukaryota.
DR   InParanoid; Q99004; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0030345; F:structural constituent of tooth enamel; IBA:GO_Central.
DR   GO; GO:0070166; P:enamel mineralization; IBA:GO_Central.
DR   InterPro; IPR004116; Amelogenin.
DR   PANTHER; PTHR46794; PTHR46794; 1.
DR   PRINTS; PR01757; AMELOGENIN.
DR   SMART; SM00818; Amelogenin; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Biomineralization; Extracellular matrix;
KW   Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..16
FT   CHAIN           17..192
FT                   /note="Amelogenin, Y isoform"
FT                   /id="PRO_0000001197"
FT   REGION          73..192
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        110..127
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        128..176
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   192 AA;  21753 MW;  92B9B0A02255290B CRC64;
     MGTWILFACL LGAAYSMPLP PHPGHPGYIN FSYEVLTPLK WYQNMLRYPY PSYGYEPVGG
     WLHHQIIPVV SQQSPQNHAL QPHHHNPMVP AQQPVVPQQP MMPVPGQHSM TPIQHHQPNL
     PLPAQQSFQP QPIQPQPHQP LQPQPPVHPI QRLPPQPPLP PIFPMQPLPP VLPDLPLEAW
     PATDKTKREE VD