GLPD_STAES
ID GLPD_STAES Reviewed; 557 AA.
AC Q8CPE6;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Aerobic glycerol-3-phosphate dehydrogenase;
DE EC=1.1.5.3;
GN Name=glpD; OrderedLocusNames=SE_0979;
OS Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176280;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 12228 / FDA PCI 1200;
RX PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT "Genome-based analysis of virulence genes in a non-biofilm-forming
RT Staphylococcus epidermidis strain (ATCC 12228).";
RL Mol. Microbiol. 49:1577-1593(2003).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a quinone + sn-glycerol 3-phosphate = a quinol +
CC dihydroxyacetone phosphate; Xref=Rhea:RHEA:18977, ChEBI:CHEBI:24646,
CC ChEBI:CHEBI:57597, ChEBI:CHEBI:57642, ChEBI:CHEBI:132124; EC=1.1.5.3;
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC -!- PATHWAY: Polyol metabolism; glycerol degradation via glycerol kinase
CC pathway; glycerone phosphate from sn-glycerol 3-phosphate (aerobic
CC route): step 1/1.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the FAD-dependent glycerol-3-phosphate
CC dehydrogenase family. {ECO:0000305}.
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DR EMBL; AE015929; AAO04576.1; -; Genomic_DNA.
DR RefSeq; NP_764534.1; NC_004461.1.
DR RefSeq; WP_002439581.1; NZ_WBME01000001.1.
DR AlphaFoldDB; Q8CPE6; -.
DR SMR; Q8CPE6; -.
DR STRING; 176280.SE_0979; -.
DR EnsemblBacteria; AAO04576; AAO04576; SE_0979.
DR KEGG; sep:SE_0979; -.
DR PATRIC; fig|176280.10.peg.953; -.
DR eggNOG; COG0578; Bacteria.
DR HOGENOM; CLU_015740_5_2_9; -.
DR OMA; CIVNAAG; -.
DR UniPathway; UPA00618; UER00674.
DR Proteomes; UP000001411; Chromosome.
DR GO; GO:0009331; C:glycerol-3-phosphate dehydrogenase complex; IEA:InterPro.
DR GO; GO:0052591; F:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity; IEA:UniProtKB-EC.
DR GO; GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006072; P:glycerol-3-phosphate metabolic process; IEA:InterPro.
DR Gene3D; 1.10.8.870; -; 1.
DR Gene3D; 3.50.50.60; -; 1.
DR InterPro; IPR031656; DAO_C.
DR InterPro; IPR038299; DAO_C_sf.
DR InterPro; IPR006076; FAD-dep_OxRdtase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR000447; G3P_DH_FAD-dep.
DR PANTHER; PTHR11985; PTHR11985; 1.
DR Pfam; PF01266; DAO; 1.
DR Pfam; PF16901; DAO_C; 1.
DR PRINTS; PR01001; FADG3PDH.
DR SUPFAM; SSF51905; SSF51905; 1.
DR PROSITE; PS00977; FAD_G3PDH_1; 1.
DR PROSITE; PS00978; FAD_G3PDH_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm; FAD; Flavoprotein; Glycerol metabolism; Oxidoreductase.
FT CHAIN 1..557
FT /note="Aerobic glycerol-3-phosphate dehydrogenase"
FT /id="PRO_0000270066"
FT BINDING 21..49
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000255"
SQ SEQUENCE 557 AA; 62276 MW; 6F6044C656324F7C CRC64;
MSLSTLKRDH IKKNLRDTEY DVVIVGGGIT GAGIALDASN RGMKVALVEM QDFAQGTSSR
STKLVHGGLR YLKQLQVGVV AETGKERAIV YENGPHVTTP EWMLLPMHKG GTFGKFSTSI
GLAMYDRLAG VKKSERKKML SKQETLNKEP LVKRDGLKGG GYYVEYRTDD ARLTIEVMKK
AAENGAEILN YTKSEHFTYD SNKKVNGIEV LDMIDGETYA IKAKKVINAS GPWVDEVRSG
DYARNNKQLR LTKGVHVVID QSKFPLGQAV YFDTEKDGRM IFAIPREGKA YVGTTDTFYD
NEKATPLTTQ EDRDYLINAI NYMFPTVNVK DEDIESTWAG IRPLILEKGK DPSEISRKDE
VWEGESGLLT IAGGKLTGYR HMALEIVDLL AKRLKQEYGL KFESCATKNL KISGGDVGGS
KNFEHFVEQK VDAAKGFGID EDVARRLASK YGSNVDQLFN IAQTAPYHDS KLPLEIYVEL
VYSIQQEMVY KPTDFLVRRS GKLYFNIQDV LDYKNAVIDV MADMLNYSET QKEAYTEEVE
VAIDEARTGN DQPATKA