GLPD_STAHJ
ID GLPD_STAHJ Reviewed; 557 AA.
AC Q4L608;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Aerobic glycerol-3-phosphate dehydrogenase;
DE EC=1.1.5.3;
GN Name=glpD; OrderedLocusNames=SH1608;
OS Staphylococcus haemolyticus (strain JCSC1435).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=279808;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCSC1435;
RX PubMed=16237012; DOI=10.1128/jb.187.21.7292-7308.2005;
RA Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C.,
RA Hiramatsu K.;
RT "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT extreme plasticity of its genome and the evolution of human-colonizing
RT staphylococcal species.";
RL J. Bacteriol. 187:7292-7308(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a quinone + sn-glycerol 3-phosphate = a quinol +
CC dihydroxyacetone phosphate; Xref=Rhea:RHEA:18977, ChEBI:CHEBI:24646,
CC ChEBI:CHEBI:57597, ChEBI:CHEBI:57642, ChEBI:CHEBI:132124; EC=1.1.5.3;
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC -!- PATHWAY: Polyol metabolism; glycerol degradation via glycerol kinase
CC pathway; glycerone phosphate from sn-glycerol 3-phosphate (aerobic
CC route): step 1/1.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the FAD-dependent glycerol-3-phosphate
CC dehydrogenase family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AP006716; BAE04917.1; -; Genomic_DNA.
DR RefSeq; WP_011275898.1; NC_007168.1.
DR AlphaFoldDB; Q4L608; -.
DR SMR; Q4L608; -.
DR STRING; 279808.SH1608; -.
DR EnsemblBacteria; BAE04917; BAE04917; SH1608.
DR GeneID; 58062197; -.
DR KEGG; sha:SH1608; -.
DR eggNOG; COG0578; Bacteria.
DR HOGENOM; CLU_015740_5_2_9; -.
DR OMA; CIVNAAG; -.
DR OrthoDB; 360065at2; -.
DR UniPathway; UPA00618; UER00674.
DR Proteomes; UP000000543; Chromosome.
DR GO; GO:0009331; C:glycerol-3-phosphate dehydrogenase complex; IEA:InterPro.
DR GO; GO:0052591; F:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity; IEA:UniProtKB-EC.
DR GO; GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006072; P:glycerol-3-phosphate metabolic process; IEA:InterPro.
DR Gene3D; 1.10.8.870; -; 1.
DR Gene3D; 3.50.50.60; -; 1.
DR InterPro; IPR031656; DAO_C.
DR InterPro; IPR038299; DAO_C_sf.
DR InterPro; IPR006076; FAD-dep_OxRdtase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR000447; G3P_DH_FAD-dep.
DR PANTHER; PTHR11985; PTHR11985; 1.
DR Pfam; PF01266; DAO; 1.
DR Pfam; PF16901; DAO_C; 1.
DR PRINTS; PR01001; FADG3PDH.
DR SUPFAM; SSF51905; SSF51905; 1.
DR PROSITE; PS00977; FAD_G3PDH_1; 1.
DR PROSITE; PS00978; FAD_G3PDH_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm; FAD; Flavoprotein; Glycerol metabolism; Oxidoreductase.
FT CHAIN 1..557
FT /note="Aerobic glycerol-3-phosphate dehydrogenase"
FT /id="PRO_0000270067"
FT BINDING 21..49
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000255"
SQ SEQUENCE 557 AA; 62821 MW; 0856390DC2F7AB13 CRC64;
MALSTLNREV IKKNLQNEEY DVVIIGGGIT GAGIALDASQ RGMKVALVEM QDFAQGTSSR
STKLVHGGLR YLKQAQIKVV AETGKERAIV YENGPHVTTP EWMLLPMHKG GTFGKFTTNL
GLTAYDRLAG VKKYERKKML SKKQTLNKEP LVKKDGLKGG GYYVEYRTDD ARLTIEVMKR
AEENGAEILN HTKSTDFIYD SKSKVRGIEV QDLLTGEMYE INAKKVINAA GPWVDEVRKK
DYTRNNKQLR LTKGVHVVID QSKFPLRQAV YFDTEKDGRM IFAIPREGKA YVGTTDTFYD
NDKTKPLTTQ EDRDYLIDAI NYMFPDVNVK DEDIESTWAG VRPLILEDGK DPSEISRKDE
IWEGKSGLLT IAGGKLTGYR HMALEIVDLL AKRLKQEYKL TFAECKTKHT PISGGDVGGS
ANFESFVERK VEEGKAIGLQ ADVAKRLASK YGSNVDKLYN IAQIAQDKDL KLPLELYVEL
VYSVQNEMVF KPTDFLIRRS GKLYFNINEV KQYKDAVVEE LAKLLNYTQS QQNEFTKEIN
IAIEEATRGN EQLAVLK