GLPF2_LACPL
ID GLPF2_LACPL Reviewed; 235 AA.
AC F9USY3;
DT 27-SEP-2017, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 1.
DT 03-AUG-2022, entry version 56.
DE RecName: Full=Glycerol uptake facilitator protein 2 {ECO:0000303|PubMed:23799297};
GN Name=glpF2 {ECO:0000303|PubMed:23799297};
GN Synonyms=dhaP {ECO:0000312|EMBL:CCC77714.1};
GN OrderedLocusNames=lp_0171 {ECO:0000312|EMBL:CCC77714.1};
OS Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
OS (Lactobacillus plantarum).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactiplantibacillus.
OX NCBI_TaxID=220668;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX PubMed=12566566; DOI=10.1073/pnas.0337704100;
RA Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P.,
RA Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J.,
RA Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M.,
RA Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M.,
RA Siezen R.J.;
RT "Complete genome sequence of Lactobacillus plantarum WCFS1.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX PubMed=22156394; DOI=10.1128/jb.06275-11;
RA Siezen R.J., Francke C., Renckens B., Boekhorst J., Wels M.,
RA Kleerebezem M., van Hijum S.A.;
RT "Complete resequencing and reannotation of the Lactobacillus plantarum
RT WCFS1 genome.";
RL J. Bacteriol. 194:195-196(2012).
RN [3]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RC STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX PubMed=23799297; DOI=10.1042/bj20130388;
RA Bienert G.P., Desguin B., Chaumont F., Hols P.;
RT "Channel-mediated lactic acid transport: a novel function for
RT aquaglyceroporins in bacteria.";
RL Biochem. J. 454:559-570(2013).
CC -!- FUNCTION: Transporter that facilitates the transmembrane diffusion of
CC water, dihydroxyacetone, glycerol and H(2)O(2). Is not permeable to
CC urea and D/L-lactic acid. {ECO:0000269|PubMed:23799297}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23799297};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
CC {ECO:0000305}.
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DR EMBL; AL935263; CCC77714.1; -; Genomic_DNA.
DR RefSeq; WP_003641766.1; NC_004567.2.
DR RefSeq; YP_004888228.1; NC_004567.2.
DR AlphaFoldDB; F9USY3; -.
DR SMR; F9USY3; -.
DR STRING; 220668.lp_0171; -.
DR EnsemblBacteria; CCC77714; CCC77714; lp_0171.
DR GeneID; 57027001; -.
DR KEGG; lpl:lp_0171; -.
DR PATRIC; fig|220668.9.peg.139; -.
DR eggNOG; COG0580; Bacteria.
DR HOGENOM; CLU_020019_9_2_9; -.
DR OMA; FTSHHYY; -.
DR PhylomeDB; F9USY3; -.
DR BioCyc; LPLA220668:G1GW0-136-MON; -.
DR Proteomes; UP000000432; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015267; F:channel activity; IEA:InterPro.
DR Gene3D; 1.20.1080.10; -; 1.
DR InterPro; IPR023271; Aquaporin-like.
DR InterPro; IPR000425; MIP.
DR InterPro; IPR022357; MIP_CS.
DR Pfam; PF00230; MIP; 1.
DR PRINTS; PR00783; MINTRINSICP.
DR SUPFAM; SSF81338; SSF81338; 1.
DR PROSITE; PS00221; MIP; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..235
FT /note="Glycerol uptake facilitator protein 2"
FT /id="PRO_0000441643"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOTIF 65..67
FT /note="NPA 1"
FT /evidence="ECO:0000305|PubMed:23799297"
FT MOTIF 186..188
FT /note="NPA 2"
FT /evidence="ECO:0000305|PubMed:23799297"
SQ SEQUENCE 235 AA; 24998 MW; 6B11997E99E37B9D CRC64;
MHGFLGEFLG TMVLIVFGVG SGAAMNLKGN YARHQNWTFI CLAWGLAVTF GVYVAGQFGS
DGHLNPAVTV GFALFGYLPM ANVWPYLLGQ FLGAFIGAVI VIIQYYPHFQ AAKTAADGNQ
VGIFATGPAI SNPVFNFLSE TIATFFFIFV LLNLGNFTQG LKPLMVGLLI VVVGQTLGGT
TGFAINPARD WAPRLAYTIL PVPNKGLANW GYAWVPMFGP LLGGILAAGL ETIIS
