ID   GLPF3_LACPL             Reviewed;         240 AA.
AC   F9UTW9;
DT   27-SEP-2017, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Glycerol uptake facilitator protein 3 {ECO:0000303|PubMed:23799297};
GN   Name=glpF3 {ECO:0000303|PubMed:23799297, ECO:0000312|EMBL:CCC77889.1};
GN   OrderedLocusNames=lp_0372 {ECO:0000312|EMBL:CCC77889.1};
OS   Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
OS   (Lactobacillus plantarum).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactiplantibacillus.
OX   NCBI_TaxID=220668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX   PubMed=12566566; DOI=10.1073/pnas.0337704100;
RA   Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P.,
RA   Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J.,
RA   Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M.,
RA   Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M.,
RA   Siezen R.J.;
RT   "Complete genome sequence of Lactobacillus plantarum WCFS1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX   PubMed=22156394; DOI=10.1128/jb.06275-11;
RA   Siezen R.J., Francke C., Renckens B., Boekhorst J., Wels M.,
RA   Kleerebezem M., van Hijum S.A.;
RT   "Complete resequencing and reannotation of the Lactobacillus plantarum
RT   WCFS1 genome.";
RL   J. Bacteriol. 194:195-196(2012).
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RC   STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX   PubMed=23799297; DOI=10.1042/bj20130388;
RA   Bienert G.P., Desguin B., Chaumont F., Hols P.;
RT   "Channel-mediated lactic acid transport: a novel function for
RT   aquaglyceroporins in bacteria.";
RL   Biochem. J. 454:559-570(2013).
CC   -!- FUNCTION: Transporter that facilitates the transmembrane diffusion of
CC       water, dihydroxyacetone, glycerol and H(2)O(2). Is not permeable to
CC       urea and D/L-lactic acid. {ECO:0000269|PubMed:23799297}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23799297};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
CC       {ECO:0000305}.
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DR   EMBL; AL935263; CCC77889.1; -; Genomic_DNA.
DR   RefSeq; WP_003641945.1; NC_004567.2.
DR   RefSeq; YP_004888403.1; NC_004567.2.
DR   AlphaFoldDB; F9UTW9; -.
DR   SMR; F9UTW9; -.
DR   STRING; 220668.lp_0372; -.
DR   EnsemblBacteria; CCC77889; CCC77889; lp_0372.
DR   GeneID; 57027179; -.
DR   GeneID; 66448463; -.
DR   KEGG; lpl:lp_0372; -.
DR   PATRIC; fig|220668.9.peg.316; -.
DR   eggNOG; COG0580; Bacteria.
DR   HOGENOM; CLU_020019_9_2_9; -.
DR   OMA; MTRTGMF; -.
DR   PhylomeDB; F9UTW9; -.
DR   BioCyc; LPLA220668:G1GW0-311-MON; -.
DR   Proteomes; UP000000432; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015267; F:channel activity; IEA:InterPro.
DR   Gene3D; 1.20.1080.10; -; 1.
DR   InterPro; IPR023271; Aquaporin-like.
DR   InterPro; IPR000425; MIP.
DR   InterPro; IPR022357; MIP_CS.
DR   Pfam; PF00230; MIP; 1.
DR   PRINTS; PR00783; MINTRINSICP.
DR   SUPFAM; SSF81338; SSF81338; 1.
DR   TIGRFAMs; TIGR00861; MIP; 1.
DR   PROSITE; PS00221; MIP; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..240
FT                   /note="Glycerol uptake facilitator protein 3"
FT                   /id="PRO_0000441644"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           70..72
FT                   /note="NPA 1"
FT                   /evidence="ECO:0000305|PubMed:23799297"
FT   MOTIF           191..193
FT                   /note="NPA 2"
FT                   /evidence="ECO:0000305|PubMed:23799297"
SQ   SEQUENCE   240 AA;  25054 MW;  13C4D503D6A842CB CRC64;
     MMKDPLALQL LGEFLGTFIL ILLGDGVVAG VTLNKSKAQN AGWVAITLGW GFAVTMGVYA
     SSFMSPAHLN PAVSLGMAVA GKFPWAYVIP YSAAQIAGGV IGGLVVWLHY YPHWQATKDA
     GAILGIFATG PGIRRYFWNF ISEVIGTFVL VFGLLAFTKG QFTAGLNPIV VGILIIAIGL
     SLGGTTGYAI NPARDLGPRI AHAVLPIANK GTSDWAYSWV PIAGPLVGGA LGALLFNVLP