ID   GLPF5_LACPL             Reviewed;         250 AA.
AC   F9UUB3;
DT   27-SEP-2017, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Glycerol uptake facilitator protein-like 5 {ECO:0000305|PubMed:23799297};
GN   Name=glpF5 {ECO:0000303|PubMed:23799297, ECO:0000312|EMBL:CCC80415.1};
GN   OrderedLocusNames=lp_3436 {ECO:0000312|EMBL:CCC80415.1};
OS   Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
OS   (Lactobacillus plantarum).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactiplantibacillus.
OX   NCBI_TaxID=220668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX   PubMed=12566566; DOI=10.1073/pnas.0337704100;
RA   Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P.,
RA   Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J.,
RA   Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M.,
RA   Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M.,
RA   Siezen R.J.;
RT   "Complete genome sequence of Lactobacillus plantarum WCFS1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX   PubMed=22156394; DOI=10.1128/jb.06275-11;
RA   Siezen R.J., Francke C., Renckens B., Boekhorst J., Wels M.,
RA   Kleerebezem M., van Hijum S.A.;
RT   "Complete resequencing and reannotation of the Lactobacillus plantarum
RT   WCFS1 genome.";
RL   J. Bacteriol. 194:195-196(2012).
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RC   STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX   PubMed=23799297; DOI=10.1042/bj20130388;
RA   Bienert G.P., Desguin B., Chaumont F., Hols P.;
RT   "Channel-mediated lactic acid transport: a novel function for
RT   aquaglyceroporins in bacteria.";
RL   Biochem. J. 454:559-570(2013).
CC   -!- FUNCTION: Probable transporter that facilitates the transmembrane
CC       diffusion of an unknown substrate. Is not permeable to water,
CC       dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid.
CC       {ECO:0000269|PubMed:23799297}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23799297};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
CC       {ECO:0000305}.
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DR   EMBL; AL935263; CCC80415.1; -; Genomic_DNA.
DR   RefSeq; WP_003643022.1; NC_004567.2.
DR   RefSeq; YP_004890929.1; NC_004567.2.
DR   AlphaFoldDB; F9UUB3; -.
DR   SMR; F9UUB3; -.
DR   STRING; 220668.lp_3436; -.
DR   EnsemblBacteria; CCC80415; CCC80415; lp_3436.
DR   KEGG; lpl:lp_3436; -.
DR   PATRIC; fig|220668.9.peg.2863; -.
DR   eggNOG; COG0580; Bacteria.
DR   HOGENOM; CLU_020019_9_2_9; -.
DR   OMA; ACFPGRK; -.
DR   PhylomeDB; F9UUB3; -.
DR   BioCyc; LPLA220668:G1GW0-2903-MON; -.
DR   Proteomes; UP000000432; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015267; F:channel activity; IEA:InterPro.
DR   CDD; cd00333; MIP; 1.
DR   Gene3D; 1.20.1080.10; -; 1.
DR   InterPro; IPR023271; Aquaporin-like.
DR   InterPro; IPR000425; MIP.
DR   InterPro; IPR022357; MIP_CS.
DR   Pfam; PF00230; MIP; 1.
DR   PRINTS; PR00783; MINTRINSICP.
DR   SUPFAM; SSF81338; SSF81338; 1.
DR   TIGRFAMs; TIGR00861; MIP; 1.
DR   PROSITE; PS00221; MIP; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..250
FT                   /note="Glycerol uptake facilitator protein-like 5"
FT                   /id="PRO_0000441646"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        230..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           75..77
FT                   /note="NPA 1"
FT                   /evidence="ECO:0000305|PubMed:23799297"
FT   MOTIF           199..201
FT                   /note="NPA 2"
FT                   /evidence="ECO:0000305|PubMed:23799297"
SQ   SEQUENCE   250 AA;  26557 MW;  58EC35972E1073FA CRC64;
     MTGSWEARYA AEFFGTLILV LLGNGAVANA FLKNTTGNDD PGLANGGWLL VASGYGLGVM
     LPAMMFGSIS GNHLNPAITI GQAVIGIFPW AHVAPYLIWQ FLGAIAGQCL ILALYWPHYR
     QTTDNEAVLG TFATSDHANS QLNGFVTEMV GTAVLIFGAM GLYRGMFFHQ NIDIANIGVG
     LLIAAMVISL GGPTGPALNP ARDLGPRLVH ALFPVPNKGS SHWEYSWVPV VAPIVGAVIG
     IWIYKIFFGL