ID   GLPF6_LACPL             Reviewed;         216 AA.
AC   F9UUD2;
DT   27-SEP-2017, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Glycerol uptake facilitator protein-like 6 {ECO:0000305|PubMed:23799297};
GN   Name=glpF6 {ECO:0000303|PubMed:23799297, ECO:0000312|EMBL:CCC80434.1};
GN   OrderedLocusNames=lp_3463 {ECO:0000312|EMBL:CCC80434.1};
OS   Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
OS   (Lactobacillus plantarum).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactiplantibacillus.
OX   NCBI_TaxID=220668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX   PubMed=12566566; DOI=10.1073/pnas.0337704100;
RA   Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P.,
RA   Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J.,
RA   Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M.,
RA   Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M.,
RA   Siezen R.J.;
RT   "Complete genome sequence of Lactobacillus plantarum WCFS1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX   PubMed=22156394; DOI=10.1128/jb.06275-11;
RA   Siezen R.J., Francke C., Renckens B., Boekhorst J., Wels M.,
RA   Kleerebezem M., van Hijum S.A.;
RT   "Complete resequencing and reannotation of the Lactobacillus plantarum
RT   WCFS1 genome.";
RL   J. Bacteriol. 194:195-196(2012).
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RC   STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX   PubMed=23799297; DOI=10.1042/bj20130388;
RA   Bienert G.P., Desguin B., Chaumont F., Hols P.;
RT   "Channel-mediated lactic acid transport: a novel function for
RT   aquaglyceroporins in bacteria.";
RL   Biochem. J. 454:559-570(2013).
CC   -!- FUNCTION: Probable transporter that facilitates the transmembrane
CC       diffusion of an unknown substrate. Is not permeable to water,
CC       dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid.
CC       {ECO:0000269|PubMed:23799297}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23799297};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
CC       {ECO:0000305}.
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DR   EMBL; AL935263; CCC80434.1; -; Genomic_DNA.
DR   RefSeq; WP_011102173.1; NC_004567.2.
DR   RefSeq; YP_004890948.1; NC_004567.2.
DR   AlphaFoldDB; F9UUD2; -.
DR   SMR; F9UUD2; -.
DR   STRING; 220668.lp_3463; -.
DR   EnsemblBacteria; CCC80434; CCC80434; lp_3463.
DR   KEGG; lpl:lp_3463; -.
DR   PATRIC; fig|220668.9.peg.2882; -.
DR   eggNOG; COG0580; Bacteria.
DR   HOGENOM; CLU_020019_3_2_9; -.
DR   OMA; IFKALMY; -.
DR   PhylomeDB; F9UUD2; -.
DR   BioCyc; LPLA220668:G1GW0-2922-MON; -.
DR   Proteomes; UP000000432; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015267; F:channel activity; IEA:InterPro.
DR   Gene3D; 1.20.1080.10; -; 1.
DR   InterPro; IPR023271; Aquaporin-like.
DR   InterPro; IPR034294; Aquaporin_transptr.
DR   InterPro; IPR000425; MIP.
DR   PANTHER; PTHR45724; PTHR45724; 1.
DR   Pfam; PF00230; MIP; 1.
DR   PRINTS; PR00783; MINTRINSICP.
DR   SUPFAM; SSF81338; SSF81338; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..216
FT                   /note="Glycerol uptake facilitator protein-like 6"
FT                   /id="PRO_0000441647"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           56..58
FT                   /note="NPA 1"
FT                   /evidence="ECO:0000305|PubMed:23799297"
FT   MOTIF           172..174
FT                   /note="NPA 2"
FT                   /evidence="ECO:0000305|PubMed:23799297"
SQ   SEQUENCE   216 AA;  22133 MW;  8FBAE12AF4867A66 CRC64;
     MRKYLAEFLG TFMLVFLGTA TVVIAKGDVL AIGLAFGLAI TVSAYAFGGI SGGHFNPAVT
     TAMLINRRID AADAIGYIIA QIIGAIVASA AVKSFVSALG LSATLLGQTD FPKIGSGMAF
     FVEALVTFLF LMVILNVTSN DHGNADFAGL TIGVTLAFLI IVALNLTGGS LNPARSIGPA
     IFAGGSALSH LWVYILAPEV GAILAAFCAR VMGSED