GLPF_MYCPN
ID GLPF_MYCPN Reviewed; 264 AA.
AC P75071;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Probable glycerol uptake facilitator protein {ECO:0000250|UniProtKB:P0AER0};
GN Name=glpF; OrderedLocusNames=MPN_043; ORFNames=MP111;
OS Mycoplasma pneumoniae (strain ATCC 29342 / M129) (Mycoplasmoides
OS pneumoniae).
OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=272634;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29342 / M129;
RX PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.;
RT "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT pneumoniae.";
RL Nucleic Acids Res. 24:4420-4449(1996).
CC -!- FUNCTION: Mediates glycerol diffusion across the cytoplasmic membrane
CC via a pore-type mechanism. {ECO:0000250|UniProtKB:P0AER0}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glycerol(in) = glycerol(out); Xref=Rhea:RHEA:29675,
CC ChEBI:CHEBI:17754; Evidence={ECO:0000250|UniProtKB:P0AER0};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- DOMAIN: Aquaporins contain two tandem repeats each containing three
CC membrane-spanning domains and a pore-forming loop with the signature
CC motif Asn-Pro-Ala (NPA). {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
CC {ECO:0000305}.
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DR EMBL; U00089; AAB95759.1; -; Genomic_DNA.
DR PIR; S73437; S73437.
DR RefSeq; NP_109731.1; NC_000912.1.
DR RefSeq; WP_010874400.1; NC_000912.1.
DR AlphaFoldDB; P75071; -.
DR SMR; P75071; -.
DR STRING; 272634.MPN_043; -.
DR EnsemblBacteria; AAB95759; AAB95759; MPN_043.
DR KEGG; mpn:MPN_043; -.
DR PATRIC; fig|272634.6.peg.42; -.
DR HOGENOM; CLU_020019_9_2_14; -.
DR OMA; MTRTGMF; -.
DR BioCyc; MPNE272634:G1GJ3-59-MON; -.
DR Proteomes; UP000000808; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015267; F:channel activity; IEA:InterPro.
DR Gene3D; 1.20.1080.10; -; 1.
DR InterPro; IPR023271; Aquaporin-like.
DR InterPro; IPR000425; MIP.
DR InterPro; IPR022357; MIP_CS.
DR Pfam; PF00230; MIP; 1.
DR PRINTS; PR00783; MINTRINSICP.
DR SUPFAM; SSF81338; SSF81338; 1.
DR PROSITE; PS00221; MIP; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..264
FT /note="Probable glycerol uptake facilitator protein"
FT /id="PRO_0000064088"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOTIF 78..80
FT /note="NPA 1"
FT /evidence="ECO:0000305"
FT MOTIF 216..218
FT /note="NPA 2"
FT /evidence="ECO:0000305"
SQ SEQUENCE 264 AA; 28305 MW; 56A3FBD375A059CC CRC64;
MFNLSDFSEL PRWIGAEFLG TFFLILSGNG AGSQLTLNKM FAKESKAKLL TAAFAWGIAV
LVGVLIANSL FEGAGNINPA VSLFYAVSGT IQKALYPLHV NFSIPLLWVA LLLAWVAQFA
GAMLAQALLN FLFWKHIEQT DPQSVLVTHC TNPAIFNIPR NFATEFVATS VLIASLLVAG
SFGANRFDQS PRGVVPMLVV TGLIMSFGAA TGTAINPARD LGPRIVYWLS PIKNKDPNLK
YSWIPVAAPL SASVILGVLV AVIV
