AMERL_HUMAN
ID AMERL_HUMAN Reviewed; 310 AA.
AC Q6DCA0; B4E276;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=AMMECR1-like protein;
GN Name=AMMECR1L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
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DR EMBL; AK304145; BAG65038.1; -; mRNA.
DR EMBL; CH471103; EAW95346.1; -; Genomic_DNA.
DR EMBL; BC016181; AAH16181.1; -; mRNA.
DR EMBL; BC078174; AAH78174.1; -; mRNA.
DR CCDS; CCDS2152.1; -.
DR RefSeq; NP_001186069.1; NM_001199140.1.
DR RefSeq; NP_113633.2; NM_031445.2.
DR AlphaFoldDB; Q6DCA0; -.
DR SMR; Q6DCA0; -.
DR BioGRID; 123698; 15.
DR IntAct; Q6DCA0; 10.
DR STRING; 9606.ENSP00000272647; -.
DR iPTMnet; Q6DCA0; -.
DR PhosphoSitePlus; Q6DCA0; -.
DR BioMuta; AMMECR1L; -.
DR DMDM; 74736367; -.
DR EPD; Q6DCA0; -.
DR jPOST; Q6DCA0; -.
DR MassIVE; Q6DCA0; -.
DR MaxQB; Q6DCA0; -.
DR PaxDb; Q6DCA0; -.
DR PeptideAtlas; Q6DCA0; -.
DR PRIDE; Q6DCA0; -.
DR ProteomicsDB; 66221; -.
DR Antibodypedia; 56027; 15 antibodies from 8 providers.
DR DNASU; 83607; -.
DR Ensembl; ENST00000272647.10; ENSP00000272647.6; ENSG00000144233.11.
DR Ensembl; ENST00000393001.1; ENSP00000376726.1; ENSG00000144233.11.
DR GeneID; 83607; -.
DR KEGG; hsa:83607; -.
DR MANE-Select; ENST00000272647.10; ENSP00000272647.6; NM_001199140.2; NP_001186069.1.
DR UCSC; uc002tpl.5; human.
DR CTD; 83607; -.
DR GeneCards; AMMECR1L; -.
DR HGNC; HGNC:28658; AMMECR1L.
DR HPA; ENSG00000144233; Low tissue specificity.
DR neXtProt; NX_Q6DCA0; -.
DR OpenTargets; ENSG00000144233; -.
DR PharmGKB; PA162376350; -.
DR VEuPathDB; HostDB:ENSG00000144233; -.
DR eggNOG; KOG3274; Eukaryota.
DR GeneTree; ENSGT00390000010397; -.
DR HOGENOM; CLU_052828_0_0_1; -.
DR InParanoid; Q6DCA0; -.
DR OMA; RMGKRRC; -.
DR OrthoDB; 1274811at2759; -.
DR PhylomeDB; Q6DCA0; -.
DR TreeFam; TF314680; -.
DR PathwayCommons; Q6DCA0; -.
DR SignaLink; Q6DCA0; -.
DR BioGRID-ORCS; 83607; 10 hits in 1073 CRISPR screens.
DR ChiTaRS; AMMECR1L; human.
DR GenomeRNAi; 83607; -.
DR Pharos; Q6DCA0; Tdark.
DR PRO; PR:Q6DCA0; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q6DCA0; protein.
DR Bgee; ENSG00000144233; Expressed in epithelial cell of pancreas and 185 other tissues.
DR ExpressionAtlas; Q6DCA0; baseline and differential.
DR Genevisible; Q6DCA0; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR Gene3D; 3.30.700.20; -; 1.
DR InterPro; IPR023473; AMMECR1.
DR InterPro; IPR036071; AMMECR1_dom_sf.
DR InterPro; IPR002733; AMMECR1_domain.
DR InterPro; IPR027485; AMMECR1_N.
DR PANTHER; PTHR13016; PTHR13016; 1.
DR Pfam; PF01871; AMMECR1; 1.
DR SUPFAM; SSF143447; SSF143447; 1.
DR TIGRFAMs; TIGR00296; TIGR00296; 1.
DR PROSITE; PS51112; AMMECR1; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..310
FT /note="AMMECR1-like protein"
FT /id="PRO_0000278479"
FT DOMAIN 97..291
FT /note="AMMECR1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00467"
FT REGION 26..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 74
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163"
SQ SEQUENCE 310 AA; 34499 MW; 6960F5A18CA02AC4 CRC64;
MGKRRCVPPL EPKLAAGCCG VKKPKLSGSG THSHGNQSTT VPGSSSGPLQ NHQHVDSSSG
RENVSDLTLG PGNSPITRMN PASGALSPLP RPNGTANTTK NLVVTAEMCC YCFDVLYCHL
YGFPQPRLPR FTNDPYPLFV TWKTGRDKRL RGCIGTFSAM NLHSGLREYT LTSALKDSRF
PPLTREELPK LFCSVSLLTN FEDASDYLDW EVGVHGIRIE FINEKGVKRT ATYLPEVAKE
QDWDQIQTID SLLRKGGFKA PITSEFRKTI KLTRYRSEKV TISYAEYIAS RQHCFQNGTL
HAPPLYNHYS
