GLPK5_BOVIN
ID GLPK5_BOVIN Reviewed; 528 AA.
AC Q08D86; Q58DK9;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Putative glycerol kinase 5;
DE Short=GK 5;
DE Short=Glycerokinase 5;
DE EC=2.7.1.30;
DE AltName: Full=ATP:glycerol 3-phosphotransferase 5;
GN Name=GK5;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=Hereford; TISSUE=Fetal skin;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate;
CC Xref=Rhea:RHEA:21644, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:57597, ChEBI:CHEBI:456216;
CC EC=2.7.1.30;
CC -!- PATHWAY: Polyol metabolism; glycerol degradation via glycerol kinase
CC pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q08D86-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q08D86-2; Sequence=VSP_032119, VSP_032120;
CC -!- SIMILARITY: Belongs to the FGGY kinase family. {ECO:0000305}.
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DR EMBL; BT021588; AAX46435.1; -; mRNA.
DR EMBL; BC123888; AAI23889.1; -; mRNA.
DR RefSeq; NP_001030550.2; NM_001035473.2. [Q08D86-1]
DR AlphaFoldDB; Q08D86; -.
DR SMR; Q08D86; -.
DR STRING; 9913.ENSBTAP00000024143; -.
DR Ensembl; ENSBTAT00000024143; ENSBTAP00000024143; ENSBTAG00000018138. [Q08D86-1]
DR Ensembl; ENSBTAT00000034692; ENSBTAP00000034578; ENSBTAG00000018138. [Q08D86-2]
DR GeneID; 616031; -.
DR KEGG; bta:616031; -.
DR CTD; 256356; -.
DR VEuPathDB; HostDB:ENSBTAG00000018138; -.
DR eggNOG; KOG2517; Eukaryota.
DR GeneTree; ENSGT01000000214434; -.
DR InParanoid; Q08D86; -.
DR OMA; CTFLTWN; -.
DR OrthoDB; 519426at2759; -.
DR UniPathway; UPA00618; UER00672.
DR Proteomes; UP000009136; Chromosome 1.
DR Bgee; ENSBTAG00000018138; Expressed in liver and 111 other tissues.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004370; F:glycerol kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IBA:GO_Central.
DR GO; GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006071; P:glycerol metabolic process; IBA:GO_Central.
DR GO; GO:0046167; P:glycerol-3-phosphate biosynthetic process; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IBA:GO_Central.
DR GO; GO:0006641; P:triglyceride metabolic process; IBA:GO_Central.
DR CDD; cd07793; FGGY_GK5_metazoa; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR000577; Carb_kinase_FGGY.
DR InterPro; IPR018485; Carb_kinase_FGGY_C.
DR InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR InterPro; IPR018484; Carb_kinase_FGGY_N.
DR InterPro; IPR037444; GK5_FGGY.
DR Pfam; PF02782; FGGY_C; 1.
DR Pfam; PF00370; FGGY_N; 1.
DR PIRSF; PIRSF000538; GlpK; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
DR PROSITE; PS00445; FGGY_KINASES_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ATP-binding; Glycerol metabolism; Kinase;
KW Nucleotide-binding; Reference proteome; Transferase.
FT CHAIN 1..528
FT /note="Putative glycerol kinase 5"
FT /id="PRO_0000323753"
FT BINDING 28
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 98
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 275
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 297
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT BINDING 439..444
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT VAR_SEQ 350..409
FT /note="DLFTDAAETEKMAQSLEDSEGVYFVPSFSGLQAPLNDPCACASFMGLKPSTN
FT KYHLVRAI -> GRMKKHSKNKNKGIISPLSVL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16305752"
FT /id="VSP_032119"
FT VAR_SEQ 410..528
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16305752"
FT /id="VSP_032120"
SQ SEQUENCE 528 AA; 58765 MW; 4616C70AE1ECF649 CRC64;
MSEQSTVPEQ SASDSRRAGF VLGVDVGSSM IRCHVYDRAA RICGSSAQKV ESLYPQPGWV
EIDPDVLWLQ FVAVIKESVK AAGIETNQIV GLGISTQRAT FITWDKKTGK HFHNFISWQD
LRATELVKSW NGSLLMKLIH SSCRVLHFFT RSKQFLAASL FTFTTQHVSL RLAWILQNLT
EVQKAVEEEN CCFGTVDTWL LHKLTKGSEF ATDFSNASTT GLFDPYEMCW SKIVTSLLSI
PLSLLPPVKD TSHNFGSVDE EIFGVPIPIV ALVADQQAAM FGECCFQTGD VKLTMGTGTF
LDINTGNNPQ QSVGGFYPLI GWKIGQEVVC LAESNAGDTG TAIEWAQQLD LFTDAAETEK
MAQSLEDSEG VYFVPSFSGL QAPLNDPCAC ASFMGLKPST NKYHLVRAIL ESIAFRNKQL
YETMQKEIHI PVRKIRADGG VCKNSFVMQM TSDLINETID RPVHIDMSCS GAASLAGLAV
GFWSDKEELK KLRQSEMVFK PQKKWQEYEV NMGNWVKAVK RSMNWYKT
